The Mind, seen in Slices
              100 billion neurons in the brain
          ๏
              Each neuron with 7 thous...
We being...
              KESM data from David Mayerich at TAMU
          ๏
              Brain Networks Lab under Dr Choe...
Road to 3D starts in 2

Phoenix
Knife Edge Scanning
          Microscope (KESM)
Phoenix
Step 1: Slice and Image

Phoenix
Step 2: Reconstruct

Phoenix
Phoenix
Phoenix
Phoenix
Automatic Tape-Collecting
          Lathe Ultramicrotome (ATLUM)

Phoenix
Step 1: Spool brain on to tape

Phoenix
Step 2: Index and store brain

Phoenix
Step 3: Take Picture in SEM

Phoenix
Step 4: Reconstruct

Phoenix
Phoenix




  Zo
     ooo
        oo
             oo
               oo
                 m
Phoenix
Phoenix




THIS IS YOUR MIND
Phoenix
Perspective
              1/50,000th of the way completed
          ๏
Phoenix
              but...
          ๏

          ...
Call to Action
              What’s required to solve the problem...
          ๏
Phoenix
              Computer Science
  ...
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Slicing Brains Very Quickly - Todd Huffman

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Video: http://ignitephoenix.blip.tv/file/1839013/

Event: Ignite Phoenix 3 @ TCA
Event Date: February 25th, 2009

I’ve been an entrepreneur for the last few years, but I’d like to tell you about my real passion in life — slicing brains into very thin slices (very quickly), and taking pictures. High-throughput quantitative analysis of neural morphology and connectivity enables awesome insights into human thought. I’ll show lots of pretty pictures and tell dazzling stories.

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Slicing Brains Very Quickly - Todd Huffman

  1. 1. The Mind, seen in Slices 100 billion neurons in the brain ๏ Each neuron with 7 thousand synapses Phoenix 700,000,000,000,000 Connections Press play.... Out of this ๏ emerges our consciousness We’re trying to ๏ observe this structure...
  2. 2. We being... KESM data from David Mayerich at TAMU ๏ Brain Networks Lab under Dr Choe Phoenix www.research.cs.tamu.edu/bnl - ATLUM data from Kenneth Hayworth & ๏ 'Bobby' Kasthuri in Lichtman Laboratory at Harvard www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm - All images are belong to the respective labs ๏ and are used with permission
  3. 3. Road to 3D starts in 2 Phoenix
  4. 4. Knife Edge Scanning Microscope (KESM) Phoenix
  5. 5. Step 1: Slice and Image Phoenix
  6. 6. Step 2: Reconstruct Phoenix
  7. 7. Phoenix
  8. 8. Phoenix
  9. 9. Phoenix
  10. 10. Automatic Tape-Collecting Lathe Ultramicrotome (ATLUM) Phoenix
  11. 11. Step 1: Spool brain on to tape Phoenix
  12. 12. Step 2: Index and store brain Phoenix
  13. 13. Step 3: Take Picture in SEM Phoenix
  14. 14. Step 4: Reconstruct Phoenix
  15. 15. Phoenix Zo ooo oo oo oo m
  16. 16. Phoenix
  17. 17. Phoenix THIS IS YOUR MIND
  18. 18. Phoenix
  19. 19. Perspective 1/50,000th of the way completed ๏ Phoenix but... ๏ Engineering problems are solvable ๏ High-throughput reconstruction of neural ๏ morphology and connectivity is going to do to neuroscience what the human genome project has done to genetics
  20. 20. Call to Action What’s required to solve the problem... ๏ Phoenix Computer Science ๏ Biology ๏ Engineering ๏ Politics & Policy ๏ Media ๏ Fund Raising ๏ Entrepreneurs ๏

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