The Mind, seen in Slices
100 billion neurons in the brain
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Each neuron with 7 thousand synapses
Phoenix
700,000,000,000,000 Connections
Press play....
Out of this
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emerges our
consciousness
We’re trying to
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observe this
structure...

We being...
KESM data from David Mayerich at TAMU
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Brain Networks Lab under Dr Choe
Phoenix
www.research.cs.tamu.edu/bnl
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ATLUM data from Kenneth Hayworth &
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'Bobby' Kasthuri in Lichtman Laboratory at
Harvard
www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm
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All images are belong to the respective labs
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and are used with permission

Road to 3D starts in 2
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Knife Edge Scanning
Microscope (KESM)
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Step 1: Slice and Image
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Step 2: Reconstruct
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Automatic Tape-Collecting
Lathe Ultramicrotome (ATLUM)
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Step 1: Spool brain on to tape
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Step 2: Index and store brain
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Step 3: Take Picture in SEM
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Step 4: Reconstruct
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\\
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Zo
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m

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THIS IS YOUR MIND

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Perspective
1/50,000th of the way completed
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but...
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Engineering problems are solvable
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High-throughput reconstruction of neural
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morphology and connectivity is going to
do to neuroscience what the human
genome project has done to genetics

Call to Action
What’s required to solve the problem...
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Phoenix
Computer Science
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Biology
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Engineering
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Politics & Policy
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Media
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Fund Raising
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Entrepreneurs
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