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Slicing Brains Very Quickly - Todd Huffman
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Slicing Brains Very Quickly - Todd Huffman

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Video: http://ignitephoenix.blip.tv/file/1839013/ …

Video: http://ignitephoenix.blip.tv/file/1839013/

Event: Ignite Phoenix 3 @ TCA
Event Date: February 25th, 2009

I’ve been an entrepreneur for the last few years, but I’d like to tell you about my real passion in life — slicing brains into very thin slices (very quickly), and taking pictures. High-throughput quantitative analysis of neural morphology and connectivity enables awesome insights into human thought. I’ll show lots of pretty pictures and tell dazzling stories.

Published in: Technology

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Transcript

  • 1. The Mind, seen in Slices 100 billion neurons in the brain ๏ Each neuron with 7 thousand synapses Phoenix 700,000,000,000,000 Connections Press play.... Out of this ๏ emerges our consciousness We’re trying to ๏ observe this structure...
  • 2. We being... KESM data from David Mayerich at TAMU ๏ Brain Networks Lab under Dr Choe Phoenix www.research.cs.tamu.edu/bnl - ATLUM data from Kenneth Hayworth & ๏ 'Bobby' Kasthuri in Lichtman Laboratory at Harvard www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm - All images are belong to the respective labs ๏ and are used with permission
  • 3. Road to 3D starts in 2 Phoenix
  • 4. Knife Edge Scanning Microscope (KESM) Phoenix
  • 5. Step 1: Slice and Image Phoenix
  • 6. Step 2: Reconstruct Phoenix
  • 7. Phoenix
  • 8. Phoenix
  • 9. Phoenix
  • 10. Automatic Tape-Collecting Lathe Ultramicrotome (ATLUM) Phoenix
  • 11. Step 1: Spool brain on to tape Phoenix
  • 12. Step 2: Index and store brain Phoenix
  • 13. Step 3: Take Picture in SEM Phoenix
  • 14. Step 4: Reconstruct Phoenix
  • 15. Phoenix Zo ooo oo oo oo m
  • 16. Phoenix
  • 17. Phoenix THIS IS YOUR MIND
  • 18. Phoenix
  • 19. Perspective 1/50,000th of the way completed ๏ Phoenix but... ๏ Engineering problems are solvable ๏ High-throughput reconstruction of neural ๏ morphology and connectivity is going to do to neuroscience what the human genome project has done to genetics
  • 20. Call to Action What’s required to solve the problem... ๏ Phoenix Computer Science ๏ Biology ๏ Engineering ๏ Politics & Policy ๏ Media ๏ Fund Raising ๏ Entrepreneurs ๏