International partnerships - Shining light on the neglected zoonoses

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Poster prepared by Elizabeth Cook, Lian Thomas, Will de Glanville, Mark Bronsvoort, Phil Toye, Bernard Agwanda, Njeri Wamae, Sam Kariuki and Eric Fèvre for the Medical Research Council (MRC) …

Poster prepared by Elizabeth Cook, Lian Thomas, Will de Glanville, Mark Bronsvoort, Phil Toye, Bernard Agwanda, Njeri Wamae, Sam Kariuki and Eric Fèvre for the Medical Research Council (MRC) centenary celebration held at the Royal Society, London, UK, 10 December 2013.

The poster won third prize in a competition organized for MRC-funded early-career researchers to communicate how international collaboration has been pivotal to their research. Elizabeth Cook's PhD studentship at the University of Edinburgh is funded by the MRC.

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  • 1. International partnerships - Shining light on the neglected zoonoses Elizabeth Cook1,2, Lian Thomas1,2, Will de Glanville1,2, Mark Bronsvoort1, Phil Toye2, Bernard Agwanda3, Njeri Wamae4, Sam Kariuki4 and Eric Fèvre2,5 1 University of Edinburgh, 2 International Livestock Research Institute, 3 National Museums of Kenya, 4 KEMRI, 5 University of Liverpool Background •Zoonoses are diseases that spread from animals to people e.g. bird flu and rabies •Poor people in developing countries are the worst affected, with livestock owners and abattoir workers at particularly high risk •The People, Animals and their Zoonoses (PAZ) project investigates zoonoses in western Kenya Outcomes Identify risk behaviours for disease Develop interventions for prevention and control Objectives Determine exposure to zoonoses in people and animals Methods Sampling procedure Questionnaire -Demographics -Socioeconomic status -Health and nutrition Study population -416 households -2113 people -983 cattle -93 pigs -129 bats and rodents 824 hospital cases Biological samples Blood, faeces 738 abattoir workers Data analysis -Estimate percentage of people/animals affected (prevalence) -Risk behaviours for disease -Spatial relationships -Food borne risk -Compare new test to “gold standard” Sample analysis -Blood and intestinal parasites -Milk fever (brucellosis) -Pig tapeworm (cysticercosis) -Sleeping sickness (trypanosomiasis) -Rift Valley Fever -Q fever Land cover mapping Partners and roles COORDINATING PARTNERS •University of Edinburgh •International Livestock Research Institute •Kenya Medical Research Institute •Department of Veterinary Services Kenya DATA ANALYSIS PARTNERS •Uni of Wisconsin •Uni of Southampton •Uni of Liverpool DIAGNOSTIC PARTNERS •Friedrich Loeffler Institute, Germany •University of Florida •Universidad de Navarra, Spain •Children’s Hospital Oakland Research Institute •Association for Strengthening Agricultural Research in East and Central Africa •Institute of Tropical Medicine, Belgium SAMPLING PARTNERS •National Museums of Kenya •University of Nairobi •Makerere University, Uganda POLICY PARTNERS •Zoonotic Disease Unit FUNDING Wellcome Trust, Biotechnology and Biological Sciences Research Council, MRC, Consultative Group on International Agricultural Research Outcomes Key Results Significance Brucellosis data Used in national control policy Cysticercosis data Develop new diagnostic test (Fig A) Trypanosomiasis Atlas of human African trypanosomiasis Rift Valley Fever First time identified in this area New bat parasite First time identified (Fig B) Abattoir standards Contribution to national standards A Additional benefits resulting from project •BIOBANK – 25,000 samples stored for future projects •Capacity building – 13 national and 12 international undergraduate and graduate students •Treatment provided to 3000+ participants B •Some diagnostic tests validated in African setting for first time •Collaboration with WHO to develop global eradication programme for cysticercosis Conclusion •Holistic approach to zoonotic disease investigation – first project to study animals and people concurrently •Multidiscipline cross cultural team allows integrated approach to understanding zoonoses in this setting •Outcomes of this project will allow development of evidence driven interventions for the prevention and control of zoonoses