Coriell Institute manages complex research data at low cost. Transforming genomic research capabilities with IBM XIV Storage System. Visit http://ibm.co/Pv0O89 to know about the IBM XIV Storage System.
Coriell Institute manages complex research data at low cost
IBM XIV Storage Systems HealthcareCase Study Coriell Institute manages complex research data at low cost Transforming genomic research capabilities with IBM XIV Storage System Coriell Institute for Medical Research, founded in 1953 and based in Overview Camden, New Jersey, is an independent nonproﬁt research organization dedicated to the study of the human genome. As a leader in the emerging The need ﬁeld of personalized medicine—which draws upon a person’s genomic A major research program at the Coriell information to tailor treatments and prescription drug dosing to optimize Institute for Medical Research generates vast amounts of genomic data; control- health outcomes—the Coriell Personalized Medicine Collaborative® ling storage costs while planning for (CPMC®) research study is seeking to understand the usefulness of growth in data volumes were major genetic risk and pharmacogenomics in clinical decision-making and challenges. healthcare management. One important aspect of the study is the integra- The solution tion of genetic risk information into patients’ electronic medical records Implemented IBM® XIV® Storage (EMR) and studying its use by physicians. System, using built-in thin provisioning to free up 30 TB of space. The solution Scott Megill, Coriell’s Chief Information Officer says, “Each person’s provides scalable, high-performance, easy-to-manage storage for genomic sequence generates approximately two million data points; genomic data. this translates into around 1 GB of raw data per patient. This data is subsequently analyzed, generating many additional gigabytes of research The beneﬁt data and reportable information. For the CPMC [Coriell Personalized Thin provisioning reduced capacity requirements from 50 TB to 20 TB, Medicine Collaborative] study to remain viable in the months and years a 60 percent saving. Scalability at to come, we needed to address the cost and complexity issues surrounding known costs enables Coriell to plan our existing storage solutions, which were facing information overload. cost-effective future expansion of its We needed a compact storage solution that would be easy to manage and genome project. that would enable us to grow capacity nondisruptively at a ﬁnancially acceptable cost per terabyte. The XIV Storage System answered all those requirements.” Game-changing technology CPMC study participants ﬁrst submit a saliva sample which is analyzed for genetic markers called single nucleotide polymorphisms (SNPs) which are associated with complex diseases, such as age-related macular
IBM XIV Storage Systems HealthcareCase Study degeneration, colon cancer, coronary artery disease, melanoma, and types 1 and 2 diabetes. The study also analyzes pharmacogenomic markers “With thin provisioning that inﬂuence our response to certain medications. This information is on the XIV system, we combined with each participant’s family, medical, and lifestyle history collected via a web portal and aggregated with the information on were immediately able relevant SNPs. to reduce our nominal storage requirements Not only are the resulting data sets enormous, Coriell also seeks to provide rapid access to them. A key study objective is to make the genetic from 50 TB to 20 TB— risk information available to patients and their doctors. The ability to a 60 percent saving.” access very large amounts of data at high speed would traditionally require large investments in high-end storage devices, along with the —Scott Megill, Chief Information Officer, Coriell ongoing management costs associated with running large and complex SAN environments. Working with Mainline—an IBM Business Partner—Coriell selected the IBM XIV Storage System, which offers tier-one performance and scalability without the associated tier-one cost and complexity. Mainline Professional Services assisted with the installation of the XIV system and provided basic training workshops for the Coriell team. Coriell purchased the solution through IBM Global Financing, which reduced the ﬁnancial impact of the acquisition by creating a tailored payment plan. “For Coriell, the XIV system provided the game-change we needed from the traditional SAN architecture,” says Megill. “Implementation took just two days, and we used the built-in XIV migration tools to move data from our existing devices. The transition to the XIV system was exceptionally easy, and we spent very little time on conﬁguration. We’re also seeing less complexity in management: the XIV interface is highly intuitive.” Efficient and simple Coriell immediately took advantage of the XIV system’s built-in thin provisioning to reduce its nominal storage requirements. At that time, Coriell had some 50 TB of capacity reserved for future data growth on its existing SAN. “With thin provisioning on the XIV system, we were immediately able to reduce our nominal storage requirements from 50 TB to 20 TB—a 60 percent saving,” says Megill. “Put simply, the XIV system removed the 2
IBM XIV Storage Systems HealthcareCase Study need to over-provide capacity as headroom. In fact, it takes away any Solution components: need to even plan future capacity; when we create a new LUN, the XIV software takes care of storage provisioning automatically.” Hardware ● IBM® XIV® Storage System He adds, “A signiﬁcant decision factor was simplicity of operation. In the past, we assigned the equivalent of two full-time employees to storage management; now that we have the XIV system in place, we have just one “With the XIV system, part-time employee. As a midsized business with a small IT staff, that makes a big difference.” we’re very conﬁdent in our ability to handle Evolving beneﬁts rapid data growth As clinicians have started to explore and utilize the genomic data of their patients, the average electronic medical record size has increased from without incurring 1 GB to 6 GB per patient. Coriell initially selected an XIV system with unsustainable costs.” 43 TB usable capacities, and has since expanded it. Other than inserting the new disk modules, no other conﬁguration or change is required, —Scott Megill, Chief Information Officer, Coriell enabling Coriell to grow its storage capacity nondisruptively and without additional device or system management costs. Adding disk also adds processors, so the XIV system performance actually increases as capacity grows. IT Environment: Operating systems Coriell retained its previous disk arrays to act as secondary storage, and ● Microsoft Windows Server uses the built-in XIV snapshot feature to move data to these legacy arrays. 2003 and 2008 “When the legacy disk arrays reach end-of-life, we plan to deploy a Databases second XIV system, and will use the built-in mirroring feature to provide ● Microsoft SQL Server 2005 complete data resilience,” says Megill. “At Coriell, all our servers are Applications virtualized, and by retaining complete server images, the second ● Microsoft Internet Information Services XIV system will give us immediate recovery should a live server fail.” ● Third-party applications for online catalogues, inventory management and ﬁnancials Cutting cost and complexity Compared with the former storage architecture, the XIV solution at Virtualization Coriell provides almost double the usable space for the same nominal disk ● VMware vSphere 4 capacity, and maintenance and management costs have more than halved. Not only are the study participants’ genome-based risk factors analyzed and stored, but the study also examines the clinicians’ behavior when using the data during consultations. Soon, information will be based on full-genome sequencing as well as metadata associated with shared EMRs from several clinical sources—signiﬁcantly increasing the per-patient data volumes. The core EMRs are expected to reach 1 TB, and fully analyzed data might reach 10 TB per patient. With low per-terabyte costs and easy management, the XIV system is ideal for managing this fast-growth environment. 3