Coriell Institute manages complex research data at low cost


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Coriell Institute manages complex research data at low cost. Transforming genomic research capabilities with IBM XIV Storage System. Visit to know about the IBM XIV Storage System.

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Coriell Institute manages complex research data at low cost

  1. 1. IBM XIV Storage Systems HealthcareCase Study Coriell Institute manages complex research data at low cost Transforming genomic research capabilities with IBM XIV Storage System Coriell Institute for Medical Research, founded in 1953 and based in Overview Camden, New Jersey, is an independent nonprofit research organization dedicated to the study of the human genome. As a leader in the emerging The need field of personalized medicine—which draws upon a person’s genomic A major research program at the Coriell information to tailor treatments and prescription drug dosing to optimize Institute for Medical Research generates vast amounts of genomic data; control- health outcomes—the Coriell Personalized Medicine Collaborative® ling storage costs while planning for (CPMC®) research study is seeking to understand the usefulness of growth in data volumes were major genetic risk and pharmacogenomics in clinical decision-making and challenges. healthcare management. One important aspect of the study is the integra- The solution tion of genetic risk information into patients’ electronic medical records Implemented IBM® XIV® Storage (EMR) and studying its use by physicians. System, using built-in thin provisioning to free up 30 TB of space. The solution Scott Megill, Coriell’s Chief Information Officer says, “Each person’s provides scalable, high-performance, easy-to-manage storage for genomic sequence generates approximately two million data points; genomic data. this translates into around 1 GB of raw data per patient. This data is subsequently analyzed, generating many additional gigabytes of research The benefit data and reportable information. For the CPMC [Coriell Personalized Thin provisioning reduced capacity requirements from 50 TB to 20 TB, Medicine Collaborative] study to remain viable in the months and years a 60 percent saving. Scalability at to come, we needed to address the cost and complexity issues surrounding known costs enables Coriell to plan our existing storage solutions, which were facing information overload. cost-effective future expansion of its We needed a compact storage solution that would be easy to manage and genome project. that would enable us to grow capacity nondisruptively at a financially acceptable cost per terabyte. The XIV Storage System answered all those requirements.” Game-changing technology CPMC study participants first submit a saliva sample which is analyzed for genetic markers called single nucleotide polymorphisms (SNPs) which are associated with complex diseases, such as age-related macular
  2. 2. IBM XIV Storage Systems HealthcareCase Study degeneration, colon cancer, coronary artery disease, melanoma, and types 1 and 2 diabetes. The study also analyzes pharmacogenomic markers “With thin provisioning that influence our response to certain medications. This information is on the XIV system, we combined with each participant’s family, medical, and lifestyle history collected via a web portal and aggregated with the information on were immediately able relevant SNPs. to reduce our nominal storage requirements Not only are the resulting data sets enormous, Coriell also seeks to provide rapid access to them. A key study objective is to make the genetic from 50 TB to 20 TB— risk information available to patients and their doctors. The ability to a 60 percent saving.” access very large amounts of data at high speed would traditionally require large investments in high-end storage devices, along with the —Scott Megill, Chief Information Officer, Coriell ongoing management costs associated with running large and complex SAN environments. Working with Mainline—an IBM Business Partner—Coriell selected the IBM XIV Storage System, which offers tier-one performance and scalability without the associated tier-one cost and complexity. Mainline Professional Services assisted with the installation of the XIV system and provided basic training workshops for the Coriell team. Coriell purchased the solution through IBM Global Financing, which reduced the financial impact of the acquisition by creating a tailored payment plan. “For Coriell, the XIV system provided the game-change we needed from the traditional SAN architecture,” says Megill. “Implementation took just two days, and we used the built-in XIV migration tools to move data from our existing devices. The transition to the XIV system was exceptionally easy, and we spent very little time on configuration. We’re also seeing less complexity in management: the XIV interface is highly intuitive.” Efficient and simple Coriell immediately took advantage of the XIV system’s built-in thin provisioning to reduce its nominal storage requirements. At that time, Coriell had some 50 TB of capacity reserved for future data growth on its existing SAN. “With thin provisioning on the XIV system, we were immediately able to reduce our nominal storage requirements from 50 TB to 20 TB—a 60 percent saving,” says Megill. “Put simply, the XIV system removed the 2
  3. 3. IBM XIV Storage Systems HealthcareCase Study need to over-provide capacity as headroom. In fact, it takes away any Solution components: need to even plan future capacity; when we create a new LUN, the XIV software takes care of storage provisioning automatically.” Hardware ● IBM® XIV® Storage System He adds, “A significant decision factor was simplicity of operation. In the past, we assigned the equivalent of two full-time employees to storage management; now that we have the XIV system in place, we have just one “With the XIV system, part-time employee. As a midsized business with a small IT staff, that makes a big difference.” we’re very confident in our ability to handle Evolving benefits rapid data growth As clinicians have started to explore and utilize the genomic data of their patients, the average electronic medical record size has increased from without incurring 1 GB to 6 GB per patient. Coriell initially selected an XIV system with unsustainable costs.” 43 TB usable capacities, and has since expanded it. Other than inserting the new disk modules, no other configuration or change is required, —Scott Megill, Chief Information Officer, Coriell enabling Coriell to grow its storage capacity nondisruptively and without additional device or system management costs. Adding disk also adds processors, so the XIV system performance actually increases as capacity grows. IT Environment: Operating systems Coriell retained its previous disk arrays to act as secondary storage, and ● Microsoft Windows Server uses the built-in XIV snapshot feature to move data to these legacy arrays. 2003 and 2008 “When the legacy disk arrays reach end-of-life, we plan to deploy a Databases second XIV system, and will use the built-in mirroring feature to provide ● Microsoft SQL Server 2005 complete data resilience,” says Megill. “At Coriell, all our servers are Applications virtualized, and by retaining complete server images, the second ● Microsoft Internet Information Services XIV system will give us immediate recovery should a live server fail.” ● Third-party applications for online catalogues, inventory management and financials Cutting cost and complexity Compared with the former storage architecture, the XIV solution at Virtualization Coriell provides almost double the usable space for the same nominal disk ● VMware vSphere 4 capacity, and maintenance and management costs have more than halved. Not only are the study participants’ genome-based risk factors analyzed and stored, but the study also examines the clinicians’ behavior when using the data during consultations. Soon, information will be based on full-genome sequencing as well as metadata associated with shared EMRs from several clinical sources—significantly increasing the per-patient data volumes. The core EMRs are expected to reach 1 TB, and fully analyzed data might reach 10 TB per patient. With low per-terabyte costs and easy management, the XIV system is ideal for managing this fast-growth environment. 3
  4. 4. “With the XIV system, we’re very confident in our ability to handle rapid data growth without incurring unsustainable costs,” says Megill. “From an IT resource perspective, we no longer have to juggle the storage assigned to each server or application—the XIV system hides all of that complexity, making it simple to manage storage requirements for multiple systems. When senior managers enquire how we manage these enormous data volumes, we just show them the XIV control console. With the XIV system, everyone ‘gets it’ straight away.” For more information Contact your IBM sales representative or IBM Business Partner, or visit us at: For more information about Coriell, please visit: Additionally, financing solutions from IBM Global Financing can enable effective cash management, protection from technology obsolescence, improved total cost of ownership and return on investment. Also, our Global Asset Recovery Services help address environmental concerns with new, more energy-efficient solutions. For more information on IBM Global Financing, visit: © Copyright IBM Corporation 2011 IBM Systems and Technology Group Route 100 Somers, New York 10589 U.S.A. Produced in the United States of America August 2011IBM and Mainline are separate companies and each is responsible All Rights Reservedfor its own products. Neither IBM nor Mainline makes anywarranties, express or implied, concerning the other’s products. IBM, the IBM logo, and XIV are trademarks of International Business Machines Corporation in the United States, other countries or both. If these and otherReferences in this publication to IBM products or services do not IBM trademarked terms are marked on their first occurrence in this information withimply that IBM intends to make them available in all countries in a trademark symbol (® or ™), these symbols indicate U.S. registered or common lawwhich IBM operates. Offerings are subject to change, extension trademarks owned by IBM at the time this information was published. Such trademarksor withdrawal without notice. All client examples cited represent may also be registered or common law trademarks in other countries. A current list ofhow some clients have used IBM products and the results they IBM trademarks is available on the web at “Copyright and trademark information” atmay have achieved. information in this document is provided “as-is” without any Other company, product and service names may be trademarks or service marks ofwarranty, either expressed or implied. others. Please Recycle TSC03129-USEN-00