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Dr priti

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    Dr priti Dr priti Presentation Transcript

    • Assessment Of Lipid Profile And Blood Glucose Levels In Cerebral Ischemic Stroke
      Dr. Priti Chaturvedi
      Resident
      Deptt. of Biochemistry
      HIHT University
    • Introduction
      Stroke is the third commonest cause of death worldwide
      Prevalence rate of stroke in India estimated at 203 per 100,000 population above 20 years (Anand K et al. 2001)
      Up to 85 % of all strokes are of ischemic origin.
      Atherosclerosis of the arteries, supplying the brain is the most common cause of ischemic stroke.
    • In several studies, ischemic stroke was associated with hypercholesterolemia, hypertriglyceridemia and increased level of LDL-C. Whereas a low HDL-C level has been reported to be associated with ischemic stroke (Laloux et al. 2004; Sarkar et al. 2008 and Narang et al. 2009).
    • However, not all studies reported an association with hypercholesterolemia (Tilvis et al. 1987; Iso et al. 2002) or hypertriglyceridemia (Sidharam, 1992; Wannamethee et al. 2000; Sacco et al. 2001). While other studies reported an inconsistent association between ischemic stroke and T-Chol, LDL-C and HDL-C (Bowman at el. (2003); Shahar at el (2003).
    • Dalal PM (1997); in a multicentric, prospective, hospital-based case-control study in the West Central region of India revealed that diabetes mellitus, hypertension, tobacco use and low hemoglobin rather than cholesterol level were the most important risk factors of ischemic stroke.
    • Aims and objectives
      To estimate lipid profile and blood glucose levels in patients of ischemic stroke of less than 24 hours duration.
      To study an association of biochemical parameter with cerebral ischemic stroke.
    • Materials and Methods
      Hospital based study was conducted on 50 diagnosed cases of cerebral ischemic stroke and compared with 25 healthy age matched controls
      Inclusion criteria:
      Age more than 18 years
      First onset of ischemic stroke (<24 hrs)
      Exclusion criteria:
      Stroke associated with MI
      Stroke associated with CNS infection
      Bio chemical parameters :
      Lipid profile
      Blood glucose
    • Results
      Comparison of baseline characteristics of controls and cases
      *p>0.05 - non significant (ns), p<0.05 - significant, p<0.01 - highly significant,
      p<0.001 - very highly significant.
    • **
      **
      **
      **
      *
      **
      *p<0.05 – significant ; ** p<0.01 - highly significant
    • Conclusions
      Cerebral ischemic stroke is associated with elevated serum levels of TAG, T-Chol, LDL-C, VLDL- C and low levels of HDL-C.
      Hyperglycemia and hypertension may be involved in the etiology of cerebral ischemic stroke.