Neoplasiia-Epithelial tumours


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Neoplasiia-Epithelial tumours

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Neoplasiia-Epithelial tumours

  1. 1. Neoplasia Epithelial tumours
  2. 2. <ul><li>Benign epithelial tumours; </li></ul><ul><li>Present in two ways: </li></ul><ul><li>Sheet of epithelial cells covering a surface (Papilloma) Solid masses of cells separated in to groups by stromal tissues (adenomas). </li></ul>
  3. 3. <ul><li>Papillomas ; </li></ul><ul><li>Wart like or papillary out growths </li></ul><ul><li>Pedunculated, </li></ul><ul><li>Sessile, </li></ul><ul><li>Villous. </li></ul>
  4. 4. Three types according to the nature of the epithelial involvement; <ul><li>Squamous cell papilloma. </li></ul><ul><li>Transitional cell papilloma </li></ul><ul><li>Columnar cell papilloma </li></ul>
  5. 5. Squamous cell papilloma. <ul><li>Skin, tongue, larynx, anus </li></ul><ul><li>Histology: Acanthosis, </li></ul><ul><li>Hyperkerotosis, </li></ul><ul><li>Parakeratosis. </li></ul>
  6. 7. Transitional cell papilloma <ul><li>See in the bladder (resembles sea anemone) Recurrence is high Haematuria </li></ul><ul><li>Columnar cell papilloma ; can see places with col ep </li></ul>
  7. 9. <ul><li>Other epithelial lesions(heterogeneous group); </li></ul><ul><li>Epithelial naevus (developmental) Verruca vulgaris (virul) Solar keratosis (sun burns) Basal cell papilloma (seborrhoeic keratosis) </li></ul>
  8. 11. Basal cell papilloma <ul><li>Soft </li></ul><ul><li>Well demarcated </li></ul><ul><li>Raised </li></ul><ul><li>Darkly stained skin lesion. </li></ul><ul><li>Histology: </li></ul><ul><li>Horn cysts </li></ul><ul><li>Basal cell with ovoid vesicular nucleus </li></ul><ul><li>Cytoplasm consist of pigmented granules </li></ul>
  9. 12. Adenoma ; <ul><li>Consist of dense collection of acini lined with cuboidal or columnar epithelium. </li></ul><ul><li>In endocrine gland adenomas no acini can be seen, (polygonal or spheroidal cells arranged in solid groups) </li></ul><ul><li>Deep tissue adenomas spherical mass of cells with a capsule. </li></ul>
  10. 15. <ul><li>Benign connective tissue tumours; </li></ul><ul><li>The neoplastic over growth of the tissue (eg muscle fibroblasts bones etc) and the individual cells or groups of the cells separate each other by intercellular substance secreted by tumour cells them selves. </li></ul><ul><li>The consistency of the tumour depends on the quality and quantity of the intercellular substance. </li></ul><ul><li>Poorly delineated stroma consist of blood vessels and connective tissues. It merge with the neoplastic tissues. </li></ul>
  11. 16. Fibroma <ul><li>Not a common tumour </li></ul><ul><li>Circumscribed collection of fibroblast </li></ul><ul><li>Collagen interlaced (Soft or hard depend on collagen) </li></ul><ul><li>Eg Skin, Stomach, Ovary etc </li></ul>
  12. 17. Myxoma: <ul><li>It is a well circumscribed, oval translucent and grey colour, Cut surface; Glistening slimy. </li></ul><ul><li>Scattered stellate cells disposed in connective tissue mucin in which net work of reticulin fibres. </li></ul><ul><li>Found in jaws, heart, and associated with other connective tissues </li></ul><ul><li>Origin may be from undifferentiated fibroblasts or primitive mesenchymal cells </li></ul>
  13. 20. Epithelial malignancies <ul><li>Epthelial Dysplasia amd squamous cell carcinomas </li></ul>
  14. 27. Basal cell carcinoma <ul><li>Seen in the skin of dark people </li></ul><ul><li>Face is the commonest site </li></ul><ul><li>Punched out ulcer </li></ul><ul><li>Locally invasive </li></ul><ul><li>Arise from basal cells </li></ul><ul><li>Histology </li></ul><ul><li>Coins or sheets of uniform basophilic cells. </li></ul><ul><li>Cells are closely packed and polyhedral in shape </li></ul><ul><li>Peripheral cell layer of the coins are columnar/cuboidel </li></ul><ul><li>Nuclei are ovoid and basophilic, and palisading </li></ul>
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