Vitamin D and cancer

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  • Hoeveel in 15 minuten hoofd en armen? Hoeveel vit D per dag nodig ?? Aangegeven is de wilde zalm, bij gekweekte slechts ca ¼ van de wilde zalm
  • Max 250 ug/dag toelaatbaar
  • Vitamin D and cancer

    1. 1. Vitamin D: from bone to cancer therapy Henk R. FrankeThe Hague, 12/4/2013 1
    2. 2. Who knows their vitamin D serumlevel? 2
    3. 3. Vitamin D serum level of an elderly youngster43 weeks: 1000 IE daily13 weeks: 3600 IE daily 3
    4. 4. Outline Vitamin D in short Cancer stem cell theory Breast cancer In vitro proof Practical guidelines 4
    5. 5. How do we acquire our vitamin D ?Sun-bathing Fatty fish 600 - Multivitamins 200 Margarine 20 - 30 IE /10 -20000 IE 1000 IE/100g IE/daily slice of bread Food only supplies < 10 % of our needs 5
    6. 6. NL 52°NVieth, J Steroid Biochem Mol Biol 2004;89-90:575 6
    7. 7. Muskiet et al, Ned TijdschrKlin Chem Labgeneesk2007;32:150 7
    8. 8. Vitamin D Regulates 200 genes that influences cell growth and differentiation which probably leads to a lesser extent of malignant degeneration (Holick, 2008) Induces apoptosis of the cancer (stem) cell Desired serum level is at least 100 nmol/l (Binkley et al, 2008) 8
    9. 9. Outline Vitamin D in short Cancer stem cell theory Breast cancer In vitro proof Practical guidelines 9
    10. 10. Cancer stem cell theory Vermeulen et al, NTvG, 10 2009;153:286
    11. 11. Kakarala et al, Cancer J 2007;13:27 11
    12. 12. Breast Tumor Content A tumor consists of a small stem cell compartment (3 -35%) and a large population of differentiated cells Number of divisions of a differentiated tumor cell: 50-60, division time: 19,5 hours, total lifetime 1170 hours 12
    13. 13. Breast Tumor Content Tumor doubling time 50-100 dagen Number of doublings needed to increase the tumor to 1 cm is 30-35 13
    14. 14. Breast Cancer and HT: early detection The Mammographic Window 2.5cm10121010 1cm108106 1mm104 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Years Premammographic Preclinical Clinical 14 Wertheimer et al. JAMA 1986;255:1311 14
    15. 15. Outline Vitamin D in short Cancer stem cell theory Breast cancer In vitro proof Practical guidelines 15
    16. 16. 5% more breastcancers present inthe left breast 16
    17. 17.  In The Netherlands each day 68 women and 63 men die from cardiovascular events¹ In The Netherlands each day 9 die from breast cancer² ¹Wassertheil-Smoller et al Hypertension 2000;36:780 ²Sluman et al NTvG 2006;150:2018 17
    18. 18. Breast cancer prevalence in the USA 18
    19. 19. The association Crew et al 2009;2(6):598 19
    20. 20. Outline Vitamin D in short Cancer stem cell theory Breast cancer In vitro proof Practical guidelines 20
    21. 21. ‘All roads lead to death’ 21
    22. 22. Apoptosis physiological, programmed cell death, during the adult lifespan each day 109 cells die It means falling of leaves and was first mentioned by Kerr in 1972 22
    23. 23. NECROSIS: cell murderAPOPTOSIS: cell suicide 23
    24. 24. HELA cell, cervix QuickTime™ en een Cinepak-decompressor carcinoma cellzijn vereist om deze afbeelding weer te geven. 24
    25. 25. Development of the QuickTime™ en een hand of an embryo Cinepak-decompressorzijn vereist om deze afbeelding weer te geven. of about 7 weeks gestational age 25
    26. 26. In vitro proof Apoptosis proliferation ratio Mark Londema 26 2009
    27. 27. Outline Vitamin D in short Cancer stem cell theory Breast cancer In vitro proof Practical guidelines 27
    28. 28. Advice Vitamin D Council, USA Children till 1 year 1000 IU/daily Children 1 to 4 years 2000 IU/daily Children 4 to 10 years 3000 IU/daily Adults 2000-5000 IU/daily www.vitamindcouncil.org 28
    29. 29. Practical AdviceEvery 2 weeks 50.000 IUThat is 3570 IU/dailyHalf time of vitamin D: 4-5 weeks 29
    30. 30. € 49,50 € 22,15Daily costs € 0,11 Daily costs € 0,16 30
    31. 31. 31
    32. 32. Calcium/vit D and cardiovascular Bolland et al, BMJ 2011;342:d2049 32
    33. 33. Calcium/vit D and cardiovascular Bolland et al, BMJ 2011;342:d2049 33
    34. 34. 34
    35. 35. @hrfranke www.henkfranke.com 35

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