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Cholesterol is considered a type of fat, a sterol to be precise. Its production starts
with sugar molecules. Please read the preceding sentence a thousand times again and
again. Yes, cholesterol production begins when the cells of the body see sugar
molecules. These sugar molecules can be glucose (found in starches, processed and
un processed foods and all vegetables), fructose (found in fruit and berries) and
galactose (found in lactose which is comprised of glucose and galactose). These sugar
molecules will be modified within the cells of the body with the end result being the
production of cholesterol.
One may ask, "Why would our bodies make such a deadly substance?" Our bodies
make cholesterol because our cells, each and every one of them, need cholesterol to
survive. Cholesterol is found in our cell's membrane, is the starting point for the
production of hormones like testosterone, estradiol, progesterone, cortisol and bile acid
salts and the list goes on. Without cholesterol in our cell's membrane and without the
other things we make from cholesterol; we will die. The cell membrane is what makes a
cell, a cell. Without a cell membrane we have no cells and there is no us. Without the
other stuff we make from cholesterol we could not survive either.

2. Getting back to how cholesterol is made I know what you are thinking; "How come I was
never told that cholesterol is made from sugar?" How come you were never told that the
very foods that DO NOT contain cholesterol or fat are the very foods that the body uses
to make cholesterol and fat. It is because doctors, dieticians and nutritionists have
forgotten themselves.
For my physician readers, remember glycolysis? Come on, I bet you do. Remember the
end product of glycolysis that thing called pyruvate. Does acetyl Co A ring a bell? It
should. It comes from the modification of pyruvate during the aerobic metabolism of
glucose. Now who out there remembers that when two molecules of acetyl Co A come
together it forms acetoacetyl Co A? Huh? Any takers?
OK, this is for extra credit. Does anyone remember that "all twenty seven carbon atoms
found in cholesterol come from acetyl CoA? (1) Mevalonate ring a bell. How about
squalene? OK, OK I will stop now. It was embarrassing for me too when I came to the
realization that I had forgotten how cholesterol was made. Even more so for me
because I was a nutritional biochemist trained at one of the most prestigious universities
in the world. And I even had forgotten this simple, basic biochemical fact. But please do
not go on thinking that the cholesterol made in the body comes from anything other than
the modification of a sugar molecule. This is so utterly important to understand and so
crucial it bears repeating. Cholesterol is made in the body from sugar. It is through the
modification of a sugar molecule that we make the majority of cholesterol in our
bodies. And this is the cholesterol that clogs up all our arteries, including our coronary
arteries, leading to subsequent heart attacks.
Now to get to cholesterol from sugar molecules requires a review of biochemical
pathways, physiological feedback loops (say that three times fast) and a whole bunch of
other biochemical mumbo jumbo which is enough to give anyone a headache. That is
why I stopped a few paragraphs ago. But do not worry for we will be reviewing no
biochemical pathways here, because there is a solution.
Suffice it to say that sugar is the starting point for cholesterol production. So every time
you eat something which contains sugar you are setting in motion the processes that
the body needs to make cholesterol.
Now it must be mentioned that the cells of the body produce a greater amount of
cholesterol than is consumed by us daily. (2) This means we are producing more
cholesterol than we are eating. So let me ask a question; if we want to effectively lower
our cholesterol and I mean effectively, would I modify my dietary intake of cholesterol or
attempt to modify the body's production of cholesterol?

3. Well, let us think this through. The body makes more cholesterol than I consume. So if I
can somehow modify how much cholesterol my body makes I will effect a greater
change on my cholesterol numbers. If I change how much cholesterol I am eating, I will
change the number less. But is this not exactly what we are doing when we change our
dietary consumption of cholesterol by following low fat, low cholesterol diets? By
following the accepted diet for reducing cholesterol you are marginally influencing the
cholesterol number.
By lowering your carbohydrate intake (I like the moniker carbs for short so from now on
when I am referring to carbohydrates I will just say carbs) you are lowering the amount
of sugar molecules a cell sees and if the cell sees less sugar the cell makes less
cholesterol. It is that simple. Really, it is.
As a side note, carbs are broken down into sugars, so whenever one eats carbs the cell
will see sugar.
Now I mentioned above and the statement was taken directly from one of the most
widely used Medical Physiology textbooks in colleges across America, that it is the
body's own production of cholesterol that contributes most to the cholesterol present in
our bodies.
So let us combine some thoughts. By lowering your carb intake the cell sees less sugar.
Less sugar means less cholesterol production by our cells and now you just altered the
most important contributor to cholesterol production in the body. Yes, again it is that
simple. So simple it is embarrassing. But wait, it gets even more embarrassing.
Ok, so some people may be wondering what happens when we eat cholesterol. After
all, doctors are taught that it is the cholesterol we eat which gets us in trouble. Are you
sitting down? I hope so because here is the kicker. When we eat cholesterol our body
actually diminishes its production of cholesterol. Huh? Do you mean to tell me that when
I eat cholesterol my body actually slows down its production of cholesterol? Yes, that is
correct.
So let us put some more ideas together. The low cholesterol diet means more whole
grains (carbs), fruits (carbs) and vegetables (carbs), and obviously less cholesterol.
Guess what you just did. You just set in motion all the body needs TO MAKE MORE
CHOLESTEROL! Can I hear a great big Oops!!!!

4. It is the classic negative biofeedback loop that makes this happen. When one ingests
cholesterol since it is a fat it can transfuse right through the cell and nuclear
membranes. Eventually it binds with the actual DNA of the cell and turns off the
production of the enzymes that make cholesterol. Specifically, the production of the
enzyme 3-hydroxy-3-methylglutaryl CoA reductase is significantly lowered. Since this is
one of the most important enzymes for cholesterol formation, turning off the production
of this enzyme will decrease the production of cholesterol in our bodies.
So that is why low cholesterol diets do not work to significantly lower the level of
cholesterol in the blood. Going through it one more time, when we eat carbs and since
the majority of cholesterol in our blood is produced by the body; we provide the cells
with what they need to make more cholesterol. And then by lowering cholesterol
consumption this sends the message to our body to make more cholesterol. This is
because our cells, when they see less cholesterol, will make more of that enzyme
mentioned above (3-hydroxy-3-methylglutaryl CoA reductase). Then more cholesterol
will be made. I refer to this as the double whammy effect.
Now you physician readers may be feeling a little uneasy because I have not mentioned
that lowering one's intake of cholesterol in the diet, will oftentimes lower the cholesterol
number in the blood stream. Yes, this does happen, but we do not see a significant
lowering of the cholesterol number. In fact, in a perfect body, and well who would that
be; you only get a lowering of about fifteen percent. So if your cholesterol is, say, 300,
which is not an uncommon number to see; by dramatically reducing the cholesterol in
your diet, you can possibly (and usually not) lower the number from 300 to 255. For
most people, this would not have lowered the cholesterol number enough, and guess
what? Now your doctor is reaching for medication to help lower the cholesterol number
more.
I often times will say to my patients and colleagues, who never seem to understand my
reasoning, because either they do not want to, or truly just don't understand, that if the
dietary contribution to your cholesterol number is only fifteen percent, what contributes
the other eighty five percent? Well, it is what your body makes of course. So would it not
make sense to try to modify my body's production of cholesterol, since this contributes
more to the cholesterol number? Of course! This makes perfect sense, but by starting
yourself on a low cholesterol diet, and by eating more carbs, and you have to eat more
carbs, because that's all that's left, again, you set in motion all the things the body
needs to make more cholesterol. OK, I think I have said enough about cholesterol and
we will now talk about the solution.

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For great Natural way to Lower your Cholesterol, Check this out:
www.healthy-inside-out.com
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