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Health Datapalooza 2013: Datalab - Steven Edwards
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Health Datapalooza 2013: Datalab - Steven Edwards

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  • 1. Office of Research and DevelopmentNational Health and Environmental Effects Research LaboratoryPhoto image area measures 2” H x 6.93” W and can be masked by acollage strip of one, two or three images.The photo image area is located 3.19” from left and 3.81” from top of page.Each image used in collage should be reduced or cropped to a maximum of2” high, stroked with a 1.5 pt white frame and positioned edge-to-edge withaccompanying images.June 25, 2013EPA Data from the Office ofResearch and DevelopmentStephen W. EdwardsEdwards.stephen@epa.govThis talk does not necessarily reflect the views of the EnvironmentalProtection Agency.
  • 2. Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology DivisionOne Stop Shopping for EPA Datahttp://epa.gov/datafinder/
  • 3. Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology DivisionComputational Toxicology Data• Aggregated Computational Toxicology Resource (ACToR)–http://www.epa.gov/actor/• Distributed Structure-Searchable Toxicity (DSSTox) Database–http://actor.epa.gov/actor/faces/DSSTox/Home.jsp• Exposure foreCaster (ExpoCastTM) Database–http://www.epa.gov/ncct/expocast/• Toxicity foreCaster (ToxCastTM) Database–http://www.epa.gov/ncct/toxcast/• Toxicity Reference Database (ToxRefDB)–http://actor.epa.gov/toxrefdb/faces/Home.jsp• Tox21 Collaboration (NIH, FDA)–http://www.epa.gov/ncct/Tox21/http://epa.gov/ncct/index.html
  • 4. Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology DivisionExposure Data• Consolidated Human Activity Database - CHAD–http://www.epa.gov/heasd/chad.html• Consumer Product Chemical Profiles Database – CPCPDB–Coming soon to ACToR: http://www.epa.gov/actor/• ExpoCast–http://www.epa.gov/ncct/expocast/• Stochastic Human Exposure and Dose Simulation Model (SHEDS)– http://www.epa.gov/heasd/research/sheds.html
  • 5. Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology DivisionDSS ToxToxCastExpoCastSHEDSVirtual Tissue,Biomarker, andAdverse Outcome PathwayKnowledgebasesToxRefDBWikiLIMSTox21 Data Housed at EPA
  • 6. Office of Research and DevelopmentNational Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology DivisionToxicological Data Shared via CEBS (NIEHS)Proteomics Core2D GelMass SpecMetabolomics /Anal Chem CoreNMRMass SpecToxicoGenomics CoreMicroarrayqPCRSequencingWikiLIMSMany different investigatorsExperimental DesignHuman, Animal, CultureTreatment ScheduleStressor (Compound)Assay descriptionsTimelineAnimal CareCell Culture ConditionsSample PreparationLaboratory/Field DataHistopathologyClinical ChemistryIn Life ObservationsBehavioral ObsDevelopmental ObsNecropsy ObsExposure biomarkersExithttp://cebs.niehs.nih.gov/