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Examining Funding Data to
Predict the Future of Research
Dr. Tom Lickiss
A portfolio company of
Overview
• Introduction to ÜberResearch
• The Research Timeline
• Aggregating and Exploring Research Funding data
• Staying at the Cutting Edge, and Predicting the
Future
• Integrating data sources - moving towards the
complete picture
A portfolio company of
A portfolio company of
A team of developers, scientists and
experts with more than 10 years
experience delivering solutions and
services for funding and research
institutions.
A portfolio company of
A team of developers, scientists and
experts with more than 10 years
experience delivering solutions and
services for funding and research
institutions.
Portfolio company of Digital Science,
the younger sibling of the Nature
Publishing group.
ICIC 2016: Examining Funding Data to Predict the Future of Research
A portfolio company of
The Research Timeline
A portfolio company of
From Idea to Impact (Inputs and Outputs)
Idea
Citations
Publications
and Patents
A portfolio company of
Idea
Grant
Application
Grant
Awarded
Conference
Publications
and Patents
Citations
From Idea to Impact (Inputs and Outputs)
A portfolio company of
1 – 5 years 2 – 3 years
Idea
Grant
Application
Grant
Awarded
Conference
Citations
3 - 8 years of relative darkness
From Idea to Impact (Inputs and Outputs)
Publications
and Patents
A portfolio company of
1 – 5 years 2 – 3 years
Idea
Grant
Application
Grant
Awarded
Conference
Citations
Publications and citations are very useful to tell you what has happened. Grants
tell you what is happening and what will happen.
3 - 8 years of relative darkness
From Idea to Impact (Inputs and Outputs)
Publications
and Patents
A portfolio company of
The Research Landscape
What does research funding look like?
A portfolio company of
What does research funding look like?
The Research Landscape
A portfolio company of
What does research funding look like?
The Research Landscape
A portfolio company of
What does research funding look like?
We help the research and funding communities understand what is going on in
research globally, and how they are involved in it.
The Research Landscape
A portfolio company of
Aggregating and Exploring Research
Funding data
A portfolio company of
A portfolio company of
Millions of Projects, at over a trillion US Dollars, from hundreds of
research funders around the World.
We collect, clean, and disambiguate data from hundreds of sources in
order to develop a body of data that can be instantly functional.
A portfolio company of
Grants Publications
Content Consolidation NLP
Disambiguation Document Matching
The Data Principle
A portfolio company of
Grants Publications
Person and institution disambiguation
Internal Data
The Data Principle
A portfolio company of
Grants Publications
Person and institution disambiguation
Internal Data
The Data Principle
Grants Publications
Person and institution disambiguation
Internal Data
A portfolio company of
Grants Publications
Person and institution disambiguation
Internal Data
Content Consolidation NLP
Document Matching
The Data Principle
Grants Publications
Person and institution disambiguation
Internal Data
Machine Learning
A portfolio company of
Grants Publications
Person and institution disambiguation
Internal Data
Content Consolidation NLP
Document Matching
The Data Principle
Grants Publications
Person and institution disambiguation
Internal Data
Search Trend Analysis
Portfolio Analysis /
Comparison
ÜberWizard for
ORCID
Machine Learning
This approach then gives us the ability to interrogate the data in any desired way.
A portfolio company of
Comparisons and Trends
See topic trends over time
A portfolio company of
Comparisons and Trends
See topic trends over time
Who are the main funders?
A portfolio company of
Comparisons and Trends
See topic trends over time
Who are the main funders?
Which Institutions are receiving the funding?
A portfolio company of
Landscape Analysis
– Brexit!
With the data disambiguated and
searchable by any parameter,
landscape analysis is extremely
simple.
A report on the potential effects
of Brexit, before the vote,
became a major source of
predictive information after it.
A portfolio company of
Availability of
information is now
helping institutions
predict how Brexit
might affect them.
Availability of
information is now
helping institutions
predict how Brexit
might affect them.
A portfolio company of
Using Research Funding to Look into the
Future
A portfolio company of
Looking into the Future
Approximately 10% of our data details either on-
going projects, or projects which have not yet
started.
This means the nature of the data itself is
forward-looking, and it will be the first place
where new trends in research will be evidenced.
Importantly, it is also a different type of
information. It is describing what is intended,
rather than what has already happened.
A portfolio company of
A Topic Example - Optogenetics
The science of using light to control the electrical activity of neural
cells or to use light as an indicator of neural activity. This is
commonly done using proteins introduced using genetic techniques.
A portfolio company of
Optogenetics
Papers
Oct. 2006 – First paper published using
the word optogenetic (with Miesenböck
as one author).
Funded Projects
Sept. 2003 – NIDA funds a project by
Gero Miesenböck entitled “Genetically
Encoded Phototriggers of Neuronal
Activity”.
Nov. 2007 – First funded project in the
Dimensions database which contains the
word optogenetic – from the BBSRC in
the UK.
The appearance of the key optogenetic protein “channelrhodopsin” in funded
projects and publications over time. If only the publications could be seen,
would this give the same impression?
A portfolio company of
Optopatch Timeline of Key Events
Papers Funded Projects
A continuation of optogenetics enabling complete activation and
recording from electrical cells using only light and recording with
super high frame per second speeds.
April 2014 – NINDS funds project for
Optopatch starting in April 2014 to finish
March 2016.
June 2014 – Hochbaum et al. publish
Optopatch method in Nature Methods
(online version).
A portfolio company of
Optopatch Timeline of Key Events
Papers Funded Projects
A continuation of optogenetics enabling complete activation and
recording from electrical cells using only light and recording with
super high frame per second speeds.
April 2014 – NINDS funds project for
Optopatch starting in April 2014 to finish
March 2016.
June 2014 – Hochbaum et al. publish
Optopatch method in Nature Methods
(online version).
Nov. 2014 – NHLBI funds project for same
group for applying the technology to heart
cells assay for cardiotoxicity testing.
No further papers yet published on this
topic.
?
A portfolio company of
Brainbow
A method to cause cells to become
fluorescent in many different colours so
that their shapes and connections to
other cells can be more easily examined.
Weissman, Lichtman and Sanes, 2007.
A portfolio company of
Brainbow Timeline of Key Events
Papers Funded Projects
Nov. 2007 - Original technical Brainbow
paper published by Livet et al.
A portfolio company of
Brainbow Timeline of Key Events
Papers Funded Projects
Nov. 2007 - Original technical Brainbow
paper published by Livet et al.
2008 – Three grants awarded including the
word “Brainbow”. Two from NIMH and
NINDS to the original Brainbow group at
Harvard, and a third from The Royal Society
to work at UCL in UK
A portfolio company of
Brainbow Timeline of Key Events
Papers Funded Projects
Nov. 2007 - Original technical Brainbow
paper published by Livet et al.
2008 – Three grants awarded including the
word “Brainbow”. Two from NIMH and
NINDS to the original Brainbow group at
Harvard, and a third from The Royal Society
to work at UCL in UKNov. 2009 - First primary research paper
published using Brainbow technology.
2011 - Eleven papers published based on
Brainbow technology.
A portfolio company of
Brainbow Timeline of Key Events
Papers Funded Projects
Nov. 2007 - Original technical Brainbow
paper published by Livet et al.
2008 – Three grants awarded including the
word “Brainbow”. Two from NIMH and
NINDS to the original Brainbow group at
Harvard, and a third from The Royal Society
to work at UCL in UKNov. 2009 - First primary research paper
published using Brainbow technology.
2009 – NINDS award grant to the Sanes Lab
for the development of the “Next
Generation of Brainbow Transgenes for
Neural Circuit Analysis”. This was one of
five grants including the word “Brainbow”
from 2009.
2011 - Eleven papers published based on
Brainbow technology.
A portfolio company of
Brainbow Timeline of Key Events
Papers Funded Projects
Nov. 2007 - Original technical Brainbow
paper published by Livet et al.
2008 – Three grants awarded including the
word “Brainbow”. Two from NIMH and
NINDS to the original Brainbow group at
Harvard, and a third from The Royal Society
to work at UCL in UKNov. 2009 - First primary research paper
published using Brainbow technology.
2009 – NINDS award grant to the Sanes Lab
for the development of the “Next
Generation of Brainbow Transgenes for
Neural Circuit Analysis”. This was one of
five grants including the word “Brainbow”
from 2009.
June 2013 - Sanes Lab publishes “Improved
tools for the Brainbow toolbox” paper in
Nature Methods – relating to work funded
2011 - Eleven papers published based on
Brainbow technology.
A portfolio company of
“siRNA”
Comparing Trends in Data
Technologies or research areas which are reducing in size can be seen
as a drop in funding before a potential drop in publications – and new
technologies can be seen to rise.
A portfolio company of
Comparing Trends in Data
Technologies or research areas which are reducing in size can be seen
as a drop in funding before a potential drop in publications – and new
technologies can be seen to rise.
“siRNA”
“CRISPR”
A portfolio company of
Confirming Expectations, or Making
Discoveries?
Zika Virus Funding
in the last 10 years
A portfolio company of
Confirming Expectations, or Making
Discoveries?
Zika Virus Funding
in the last 10 years
Of course, with these
examples you need to
know what to look for.
However, using
Natural Language
Processing and
analysis of key term
frequencies, we are
now starting to do
automatic
identification of new
trends.
A portfolio company of
Integrating data sources - moving
towards a more complete picture
Patents & Patent
Applications
Publications
Grants
Data
Clinical Trials
Other databases
Platform Data
Researcher
Activities
Institutional
Structure
Grant
Applications
University Data
Progress
Reports
Grant
Applications
Funder Data
Base Data Enrichment Processes Enriched Data
Funding data as part of the bigger
picture
Reference
Extraction
Categorization
Organization
Extraction
Researcher
Disambiguation
Patents & Patent
Applications
Publications
Grants
Data
Clinical Trials
Other databases
Platform Data
Researcher
Activities
Institutional
Structure
Grant
Applications
University Data
Progress
Reports
Grant
Applications
Funder Data
Concept
Extraction
Base Data Enrichment Processes Enriched Data
Funding data as part of the bigger
picture
Reference
Extraction
Categorization
Organization
Extraction
Researcher
Disambiguation
Patents & Patent
Applications
Concepts
Publications
Grants
Data
Clinical Trials
Other databases
Platform Data
Researcher
Activities
Institutional
Structure
Grant
Applications
University Data
Progress
Reports
Grant
Applications
Funder Data
Researchers
Organizations
Classifications
References Metrics
Concept
Extraction
Base Data Enrichment Processes Enriched Data
Funding data as part of the bigger
picture
A portfolio company of
The Complete Picture
Funded Research
Project
Research
Undertaken
Patents and
Publications
Citations,
awareness in
the field
New
applications
for funding
Funding is of course
only one piece of the
puzzle – but an
important piece!
Funded Research
Projects are the last
major piece of the
research process
puzzle, but when
used effectively can
be hugely
informative about
the direction of
things to come.
Thank you
tom@uberresearch.com
www.uberresearch.com

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ICIC 2016: Examining Funding Data to Predict the Future of Research

  • 1. Examining Funding Data to Predict the Future of Research Dr. Tom Lickiss
  • 2. A portfolio company of Overview • Introduction to ÜberResearch • The Research Timeline • Aggregating and Exploring Research Funding data • Staying at the Cutting Edge, and Predicting the Future • Integrating data sources - moving towards the complete picture
  • 4. A portfolio company of A team of developers, scientists and experts with more than 10 years experience delivering solutions and services for funding and research institutions.
  • 5. A portfolio company of A team of developers, scientists and experts with more than 10 years experience delivering solutions and services for funding and research institutions. Portfolio company of Digital Science, the younger sibling of the Nature Publishing group.
  • 7. A portfolio company of The Research Timeline
  • 8. A portfolio company of From Idea to Impact (Inputs and Outputs) Idea Citations Publications and Patents
  • 9. A portfolio company of Idea Grant Application Grant Awarded Conference Publications and Patents Citations From Idea to Impact (Inputs and Outputs)
  • 10. A portfolio company of 1 – 5 years 2 – 3 years Idea Grant Application Grant Awarded Conference Citations 3 - 8 years of relative darkness From Idea to Impact (Inputs and Outputs) Publications and Patents
  • 11. A portfolio company of 1 – 5 years 2 – 3 years Idea Grant Application Grant Awarded Conference Citations Publications and citations are very useful to tell you what has happened. Grants tell you what is happening and what will happen. 3 - 8 years of relative darkness From Idea to Impact (Inputs and Outputs) Publications and Patents
  • 12. A portfolio company of The Research Landscape What does research funding look like?
  • 13. A portfolio company of What does research funding look like? The Research Landscape
  • 14. A portfolio company of What does research funding look like? The Research Landscape
  • 15. A portfolio company of What does research funding look like? We help the research and funding communities understand what is going on in research globally, and how they are involved in it. The Research Landscape
  • 16. A portfolio company of Aggregating and Exploring Research Funding data
  • 18. A portfolio company of Millions of Projects, at over a trillion US Dollars, from hundreds of research funders around the World. We collect, clean, and disambiguate data from hundreds of sources in order to develop a body of data that can be instantly functional.
  • 19. A portfolio company of Grants Publications Content Consolidation NLP Disambiguation Document Matching The Data Principle
  • 20. A portfolio company of Grants Publications Person and institution disambiguation Internal Data The Data Principle
  • 21. A portfolio company of Grants Publications Person and institution disambiguation Internal Data The Data Principle Grants Publications Person and institution disambiguation Internal Data
  • 22. A portfolio company of Grants Publications Person and institution disambiguation Internal Data Content Consolidation NLP Document Matching The Data Principle Grants Publications Person and institution disambiguation Internal Data Machine Learning
  • 23. A portfolio company of Grants Publications Person and institution disambiguation Internal Data Content Consolidation NLP Document Matching The Data Principle Grants Publications Person and institution disambiguation Internal Data Search Trend Analysis Portfolio Analysis / Comparison ÜberWizard for ORCID Machine Learning This approach then gives us the ability to interrogate the data in any desired way.
  • 24. A portfolio company of Comparisons and Trends See topic trends over time
  • 25. A portfolio company of Comparisons and Trends See topic trends over time Who are the main funders?
  • 26. A portfolio company of Comparisons and Trends See topic trends over time Who are the main funders? Which Institutions are receiving the funding?
  • 27. A portfolio company of Landscape Analysis – Brexit! With the data disambiguated and searchable by any parameter, landscape analysis is extremely simple. A report on the potential effects of Brexit, before the vote, became a major source of predictive information after it.
  • 29. Availability of information is now helping institutions predict how Brexit might affect them.
  • 30. Availability of information is now helping institutions predict how Brexit might affect them.
  • 31. A portfolio company of Using Research Funding to Look into the Future
  • 32. A portfolio company of Looking into the Future Approximately 10% of our data details either on- going projects, or projects which have not yet started. This means the nature of the data itself is forward-looking, and it will be the first place where new trends in research will be evidenced. Importantly, it is also a different type of information. It is describing what is intended, rather than what has already happened.
  • 33. A portfolio company of A Topic Example - Optogenetics The science of using light to control the electrical activity of neural cells or to use light as an indicator of neural activity. This is commonly done using proteins introduced using genetic techniques.
  • 34. A portfolio company of Optogenetics Papers Oct. 2006 – First paper published using the word optogenetic (with Miesenböck as one author). Funded Projects Sept. 2003 – NIDA funds a project by Gero Miesenböck entitled “Genetically Encoded Phototriggers of Neuronal Activity”. Nov. 2007 – First funded project in the Dimensions database which contains the word optogenetic – from the BBSRC in the UK. The appearance of the key optogenetic protein “channelrhodopsin” in funded projects and publications over time. If only the publications could be seen, would this give the same impression?
  • 35. A portfolio company of Optopatch Timeline of Key Events Papers Funded Projects A continuation of optogenetics enabling complete activation and recording from electrical cells using only light and recording with super high frame per second speeds. April 2014 – NINDS funds project for Optopatch starting in April 2014 to finish March 2016. June 2014 – Hochbaum et al. publish Optopatch method in Nature Methods (online version).
  • 36. A portfolio company of Optopatch Timeline of Key Events Papers Funded Projects A continuation of optogenetics enabling complete activation and recording from electrical cells using only light and recording with super high frame per second speeds. April 2014 – NINDS funds project for Optopatch starting in April 2014 to finish March 2016. June 2014 – Hochbaum et al. publish Optopatch method in Nature Methods (online version). Nov. 2014 – NHLBI funds project for same group for applying the technology to heart cells assay for cardiotoxicity testing. No further papers yet published on this topic. ?
  • 37. A portfolio company of Brainbow A method to cause cells to become fluorescent in many different colours so that their shapes and connections to other cells can be more easily examined. Weissman, Lichtman and Sanes, 2007.
  • 38. A portfolio company of Brainbow Timeline of Key Events Papers Funded Projects Nov. 2007 - Original technical Brainbow paper published by Livet et al.
  • 39. A portfolio company of Brainbow Timeline of Key Events Papers Funded Projects Nov. 2007 - Original technical Brainbow paper published by Livet et al. 2008 – Three grants awarded including the word “Brainbow”. Two from NIMH and NINDS to the original Brainbow group at Harvard, and a third from The Royal Society to work at UCL in UK
  • 40. A portfolio company of Brainbow Timeline of Key Events Papers Funded Projects Nov. 2007 - Original technical Brainbow paper published by Livet et al. 2008 – Three grants awarded including the word “Brainbow”. Two from NIMH and NINDS to the original Brainbow group at Harvard, and a third from The Royal Society to work at UCL in UKNov. 2009 - First primary research paper published using Brainbow technology. 2011 - Eleven papers published based on Brainbow technology.
  • 41. A portfolio company of Brainbow Timeline of Key Events Papers Funded Projects Nov. 2007 - Original technical Brainbow paper published by Livet et al. 2008 – Three grants awarded including the word “Brainbow”. Two from NIMH and NINDS to the original Brainbow group at Harvard, and a third from The Royal Society to work at UCL in UKNov. 2009 - First primary research paper published using Brainbow technology. 2009 – NINDS award grant to the Sanes Lab for the development of the “Next Generation of Brainbow Transgenes for Neural Circuit Analysis”. This was one of five grants including the word “Brainbow” from 2009. 2011 - Eleven papers published based on Brainbow technology.
  • 42. A portfolio company of Brainbow Timeline of Key Events Papers Funded Projects Nov. 2007 - Original technical Brainbow paper published by Livet et al. 2008 – Three grants awarded including the word “Brainbow”. Two from NIMH and NINDS to the original Brainbow group at Harvard, and a third from The Royal Society to work at UCL in UKNov. 2009 - First primary research paper published using Brainbow technology. 2009 – NINDS award grant to the Sanes Lab for the development of the “Next Generation of Brainbow Transgenes for Neural Circuit Analysis”. This was one of five grants including the word “Brainbow” from 2009. June 2013 - Sanes Lab publishes “Improved tools for the Brainbow toolbox” paper in Nature Methods – relating to work funded 2011 - Eleven papers published based on Brainbow technology.
  • 43. A portfolio company of “siRNA” Comparing Trends in Data Technologies or research areas which are reducing in size can be seen as a drop in funding before a potential drop in publications – and new technologies can be seen to rise.
  • 44. A portfolio company of Comparing Trends in Data Technologies or research areas which are reducing in size can be seen as a drop in funding before a potential drop in publications – and new technologies can be seen to rise. “siRNA” “CRISPR”
  • 45. A portfolio company of Confirming Expectations, or Making Discoveries? Zika Virus Funding in the last 10 years
  • 46. A portfolio company of Confirming Expectations, or Making Discoveries? Zika Virus Funding in the last 10 years Of course, with these examples you need to know what to look for. However, using Natural Language Processing and analysis of key term frequencies, we are now starting to do automatic identification of new trends.
  • 47. A portfolio company of Integrating data sources - moving towards a more complete picture
  • 48. Patents & Patent Applications Publications Grants Data Clinical Trials Other databases Platform Data Researcher Activities Institutional Structure Grant Applications University Data Progress Reports Grant Applications Funder Data Base Data Enrichment Processes Enriched Data Funding data as part of the bigger picture
  • 49. Reference Extraction Categorization Organization Extraction Researcher Disambiguation Patents & Patent Applications Publications Grants Data Clinical Trials Other databases Platform Data Researcher Activities Institutional Structure Grant Applications University Data Progress Reports Grant Applications Funder Data Concept Extraction Base Data Enrichment Processes Enriched Data Funding data as part of the bigger picture
  • 50. Reference Extraction Categorization Organization Extraction Researcher Disambiguation Patents & Patent Applications Concepts Publications Grants Data Clinical Trials Other databases Platform Data Researcher Activities Institutional Structure Grant Applications University Data Progress Reports Grant Applications Funder Data Researchers Organizations Classifications References Metrics Concept Extraction Base Data Enrichment Processes Enriched Data Funding data as part of the bigger picture
  • 51. A portfolio company of The Complete Picture Funded Research Project Research Undertaken Patents and Publications Citations, awareness in the field New applications for funding Funding is of course only one piece of the puzzle – but an important piece! Funded Research Projects are the last major piece of the research process puzzle, but when used effectively can be hugely informative about the direction of things to come.