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Hadorn Acal 2009 02

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Embryogenic evolution emulates in silico cell-like entities to get more powerful methods for complex evolutionary tasks. As simulations have to abstract from the biological model, implicit information ...

Embryogenic evolution emulates in silico cell-like entities to get more powerful methods for complex evolutionary tasks. As simulations have to abstract from the biological model, implicit information hidden in its physics is lost. Here, we propose to use cell-like entities as a real-world in vitro testbed. In analogy to evolutionary robotics, where solutions evolved in simulations may be tested in real-world on macroscale, the proposed vesicular testbed would do the same for the embryogenic evolutionary tasks on mesoscale. As a first step towards a vesicular testbed emulating growth, cell division, and cell differentiation, we present a modified vesicle production method, providing custom tailored chemical cargo, and present a novel self-assembly procedure to provide vesicle aggregates of programmable composition.

Vesicular Testbeds for Embryogenic Evolutionary Systems – How to Connect Wet and Soft Artificial Life. The Fourth Australian Conference on Artificial Life (ACAL09), Melbourne, Australia (1-4 December 2009), 20 minutes oral presentation.

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Hadorn Acal 2009 02 Hadorn Acal 2009 02 Presentation Transcript

  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller Institute Vesicular Testbeds for Embryogenic Evolutionary Systems – How to Connect Wet and Soft Artificial LifeLiving vesicles = Engineering living from non-living by...Why Technology Why multivesicular aggregates« … exploiting life‟s principles in technology. » Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processingMultivesicular Assemblies as Real-world Testbeds / „soft‟ composite artificial tissues for EmbryogenicEvolutionary Systems materials • be used as bioreactorspp. 169-178Bedau MA, McCaskill JS, Packard NH, and Rasmussen S Living Technology: Exploiting Lifes Principles inTechnology. Artificial Life in press (doi:10.1162/artl.2009.16.1.16103). Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Traditional Engineering Methods =masterpieces of human design ASIMOWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactors www.flickr.com Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:HYDRA =„living‟ building blocks for self-designing artefacts«Why vesiclestheir well-known advantages,Why multivesicular methods Despite traditional engineering aggregates are inflexible and unreliable when compared to biological organisms. The experts behind the HYDRA project, therefore, aggregates could: Multivesicular are contemplating • serve as models for biological a novel architecture for the development of artefacts inspired by cell-tissue biology and based on simple building •blocks. The potential offor processing lead to new methods the new design standard will be exemplified artificial tissues / „soft‟ composite through the construction of materials robotic systems that can change morphology, and result in flexible, • be used as bioreactors robust and applicable artefacts far beyond any known conventional engineering perspective. » HYDRA, IST-2001-33060, 2001–2004.http://hydra.mip.sdu.dk/home.html Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger View slide
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Modular Robotics =getting inspired by nature Ability to reconfigureWhy vesicles Why multivesicular aggregates Robustness Multivesicular aggregates could: Adaptivity • serve as models for biological tissue • lead to new methods for processing Ability of self-repair artificial tissues / „soft‟ composite Lower production costs materials • be used as bioreactors http://hydra.mip.sdu.dk/home.html Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger View slide
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Modular Robotics Meets Traditional Engineering =struggle with technical problemsWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactorshttp://hydra.mip.sdu.dk/home.html Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Soft Is Smart =exploiting material propertiesWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactors http://video.google.ch/videoplay?docid=-5865891654546717645&hl=de# Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Soft Is Smart =exploiting material propertiesWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactorsDumais J (2007). Can mechanics control pattern formation in plants? Current Opinion in Plant Biology 10(1):58-62. Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Soft Is Smart =exploiting material propertiesWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactors James Estrin/The New York Times Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:“Soft Is Hard” (Dr. Walker) =struggle with nasty little technical problems« [Dr. Walker of Clemson] cautioned that soft is hard and that aggregatesWhy vesicles Why multivesicular the road ahead could be far longer and more difficult than it seems today for the Tufts researchers [because] “it‟sMultivesicular aggregates could: very hard to engineer with all- • serve as along the biological tissue soft components. We had to make compromises models forway”. • lead to new methods for processing There [are] other challenges. artificial tissues / „soft‟ composite Designing computer programs materials to operate the arm was • be used as bioreactors something “we thought we would spend six months working out,” he recalled. “Two or three Ph.D. theses later, we http://www.ces.clemson.edu/~ianw/ finally understood the problem. Not that we had solved the » http://www.nytimes.com/2007/03/27/science/27r problem. We understood the obo.html?pagewanted=2&_r=3&ei=5070&en=9 problem.” 1395fe7439a5b72&ex=1177128000 Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Keep It Simple =control inspired by natureEggenberger Hotz P, 2004. CEC 2004.Why vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactorsEggenberger Hotz P, 2004. Artificial LifeIX. Eggenberger Hotz P, 2003. in On Growth, Form and Computers. Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteBackground:Vesicles =the C of the CMP-model (Compartment, Metabolism, Program)Why vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactorsHadorn M, Burla B, and Eggenberger Hotz P (2009). Towards Tailored Communication Networks in Assemblies ofArtificial Cells. 4th Australian Conference on Artificial Life. Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteResult:Multiple Addresses =self-assembled MCCNs of defined architectureWhy vesicles Why multivesicular aggregates Multivesicular aggregates could: α„ / γ • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials α/β β„ / γ„ • be used as bioreactors Hadorn M and Eggenberger Hotz P (2010). Towards Personalized Drug Delivery: Preparation of an Encapsulated Multicompartment System. Valencia, Spain, Jan 20-23, 2010. Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteDiscussion:Bring in the Genes =bring in the M and P of the CMP-model (Compartment, Metabolism,Program)Why vesicles Why multivesicular aggregates Multivesicular aggregates could: • serve as models for biological tissue • lead to new methods for processing artificial tissues / „soft‟ composite materials • be used as bioreactorsNoireaux V and Libchaber A (2004). A vesicle bioreactor as a step toward an artificial cell assembly. Proceedingsof the National Academy of Sciences of the United States of America 101(51):17669-17674. Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger
  • University of Zurich, Department of Informatics, Artificial Intelligence Laboratory University of Southern Denmark, Mærsk Mc-Kinney Møller InstituteAcknowledgmentsWhy vesicles Eggenberger Hotz Peter Why multivesicular aggregates Associated Professor Mærsk Mc-Kinney Møller Institute Multivesicular aggregates could: University of Southern Denmark • serve as models for biological tissue Rolf Pfeifer • lead to new methods for processing Prof. artificial tissues / „soft‟ composite Artificial Intelligence Laboratory materials University of Zurich • be used as bioreactors Enrico Martinoia Eva Bönzli Doctoral Student Prof. Faculty of Veterinary Medicine Institute of Plant Biology University of Zurich University of Zurich Bo Burla Doctoral Student Institute of Plant Biology SNF-Project EES EU_Project PACE University of Zurich 200020-118127 EU-IST-FP6-FET-002035 Multivesicular Assemblies as Real-world Testbeds for Embryogenic Evolutionary Systems ACAL‟09, 03-Dec-09 M. Hadorn / P. Eggenberger