Advanced Software Features for the LA-950 Particle Size Analyzer
 

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Advanced Software Features for the LA-950 Particle Size Analyzer

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Ian Treviranus from HORIBA Scientific (www.horiba.com/particle) provides short overviews of several software features in the LA-950 Particle Size Analyzer. The software contains many software ...

Ian Treviranus from HORIBA Scientific (www.horiba.com/particle) provides short overviews of several software features in the LA-950 Particle Size Analyzer. The software contains many software functions to improve how users make measurements, analyze measurements, and then verify the quality of the measurements. The following functions are covered in this webinar: Method Expert & Navigator for one-button operation, Automatic refractive index optimization, Intensity Graph, Multimodal Report, Automated COV calculation, and much more.

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Advanced Software Features for the LA-950 Particle Size Analyzer Presentation Transcript

  • 1. Advanced Software Features for the LA-950 Ian Treviranus ian.treviranus@horiba.com www.horiba.com/us/particle© 2012 HORIBA, Ltd. All rights reserved.
  • 2. What we’ll talk about Measurement tools Data analysis tools Data verification tools Q&A© 2012 HORIBA, Ltd. All rights reserved.
  • 3. One-button Measurement Use the Navigator or Method Expert to create Sequence (.seq) files Manual: Navigator Auto: Method Expert© 2012 HORIBA, Ltd. All rights reserved.
  • 4. LA-950 Method Expert  Unique guided method development  Optimize parameters  Choose the best refractive index  Create “one button” SOPs  Webinar TE004 for Method Expert© 2012 HORIBA, Ltd. All rights reserved.
  • 5. Collecting and Calculating The LA-950 hardware collects scattered light data The LA-950 software calculates the particle size distribution using that scattered light data Both must be optimized to maximize data quality© 2012 HORIBA, Ltd. All rights reserved.
  • 6. LA-950 Method Expert© 2012 HORIBA, Ltd. All rights reserved.
  • 7. Method Expert Hardware There are four important tests… Circulation Concentration Dispersion Duration© 2012 HORIBA, Ltd. All rights reserved.
  • 8. Method Expert Calculation There are two important tests… Real RI Imaginary RI© 2012 HORIBA, Ltd. All rights reserved.
  • 9. LA-950 Method Expert Why is the test important? What does the test do? How will the results be displayed? What is the best value? User selects up to 5 values for testing© 2012 HORIBA, Ltd. All rights reserved.
  • 10. LA-950 Method Expert Method Expert guides user to prepare the LA-950 for each test Results displayed in multiple formats: PSD, D50, R-parameter© 2012 HORIBA, Ltd. All rights reserved.
  • 11. LA-950 Method Expert© 2012 HORIBA, Ltd. All rights reserved.
  • 12. LA-950 Method Expert© 2012 HORIBA, Ltd. All rights reserved.
  • 13. Dry Measurement Method Expert currently wet only Use “Auto Measurement” for dry Webinar TE016: Optimizing Dry Powder Measurements© 2012 HORIBA, Ltd. All rights reserved.
  • 14. Navigator LA Navigator function creates Sequence programs to operate the LA-950 Maximum flexibility© 2012 HORIBA, Ltd. All rights reserved.
  • 15. Navigator© 2012 HORIBA, Ltd. All rights reserved.
  • 16. Navigator© 2012 HORIBA, Ltd. All rights reserved.
  • 17. Automatic Dilution Concentration control Adds dispersant, drains, repeat Is not possible without fill pump© 2012 HORIBA, Ltd. All rights reserved.
  • 18. Automatic Dilution© 2012 HORIBA, Ltd. All rights reserved.
  • 19. What we’ll talk about Measurement tools Data analysis tools Data verification tools Q&A© 2012 HORIBA, Ltd. All rights reserved.
  • 20. Refractive Index Many, many resources on website Webinar TR009: Optimization of RI© 2012 HORIBA, Ltd. All rights reserved.
  • 21. Manually Changing RI© 2012 HORIBA, Ltd. All rights reserved.
  • 22. Manually Changing RI© 2012 HORIBA, Ltd. All rights reserved.
  • 23. Manual Optimization© 2012 HORIBA, Ltd. All rights reserved.
  • 24. Automated RI Computation  Real part study  Need to fix imaginary part  Set up to 5 real parts  Software will compute all RI and display R parameter variation with RI selection© 2012 HORIBA, Ltd. All rights reserved.
  • 25. Automated RI Computation© 2012 HORIBA, Ltd. All rights reserved.
  • 26. Automated RI Computation© 2012 HORIBA, Ltd. All rights reserved.
  • 27. Automated RI Computation  Imaginary part study  Need to fix real part  Set up to 5 imaginary parts  Software will compute all RI and display R parameter variation with RI selection© 2012 HORIBA, Ltd. All rights reserved.
  • 28. Automated RI Computation Imaginary study© 2012 HORIBA, Ltd. All rights reserved.
  • 29. Error Calculations Emulsion Sample Figure 3yi The measured scattered light at each channel (i) of the detector.y (xi) The calculated scattered light at each channel (i) of the detector based on the chosen refractive index kernel and reported particle size distribution.i The standard deviation of the scattered light intensity at each channel (i) of the detector. A larger i indicates lower reliability of the signal on a given detector.N The number of detectors used for the calculation © 2012 HORIBA, Ltd. All rights reserved.
  • 30. Multimodal Report Hard to use full-distribution metrics to describe multimodal results D10 D50 D90 Are these meaningful?© 2012 HORIBA, Ltd. All rights reserved.
  • 31. Multimodal Report© 2012 HORIBA, Ltd. All rights reserved.
  • 32. Multimodal Report Deconvolute distribution into components© 2012 HORIBA, Ltd. All rights reserved.
  • 33. Multimodal Report Statistics for each distribution mode Better understanding of entire distribution© 2012 HORIBA, Ltd. All rights reserved.
  • 34. Intensity Graph Diffraction analyzer measures light scattering pattern, algorithm transforms this into a particle size distribution© 2012 HORIBA, Ltd. All rights reserved.
  • 35. Size affects intensity  LARGE PARTICLE:  Low angle scatter  Large signal Wide Pattern - Low intensity  SMALL PARTICLE: Narrow Pattern - High intensity  High Angle Scatter  Small Signal© 2012 HORIBA, Ltd. All rights reserved.
  • 36. Intensity Graph© 2012 HORIBA, Ltd. All rights reserved.
  • 37. Intensity Graph One way to use the Intensity Graph Two results, one good and one bad© 2012 HORIBA, Ltd. All rights reserved.
  • 38. Intensity Graph Not Passing Low Angle High Angle Large Particle Small Particle Passing© 2012 HORIBA, Ltd. All rights reserved.
  • 39. Blank Check Need to explain difference in scattering Try other tools, i.e. Blank Check© 2012 HORIBA, Ltd. All rights reserved.
  • 40. Blank Check© 2012 HORIBA, Ltd. All rights reserved.
  • 41. Custom Calculations© 2012 HORIBA, Ltd. All rights reserved.
  • 42. What we’ll talk about Measurement tools Data analysis tools Data verification tools Q&A© 2012 HORIBA, Ltd. All rights reserved.
  • 43. Automate COV Calculation Coefficient of Variation indicates precision of multiple measurements ISO 13320 and USP <429> make recommendations using COV© 2012 HORIBA, Ltd. All rights reserved.
  • 44. Automate COV Calculation© 2012 HORIBA, Ltd. All rights reserved.
  • 45. Automate COV Calculation© 2012 HORIBA, Ltd. All rights reserved.
  • 46. Result Verification© 2012 HORIBA, Ltd. All rights reserved.
  • 47. What we’ll talk about Measurement tools Data analysis tools Data verification tools Q&A© 2012 HORIBA, Ltd. All rights reserved.
  • 48. ありがとうございました ขอบคุณครั บ 谢谢 Gracias ُْ ‫اشكر‬ Grazie Σας ευχαριστούμε ध यवादTacka dig நன்ற Danke Obrigado 감사합니다 Большое спасибо© 2012 HORIBA, Ltd. All rights reserved.
  • 49. To Learn More: www.horiba.com/particle Talk to us, ask questions labinfo@horiba.com Receive news of updates View application & technical notes (160+), webinars (50+), white papers.© 2012 HORIBA, Ltd. All rights reserved.