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Green Chemistry-An overview

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This is part of our in-house training programme where I had presented this.

This is part of our in-house training programme where I had presented this.

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Transcript

  • 1. Solvents in the pharmaceutical use & The Green chemistry
  • 2.
    • Solvents
    • Solvent chemistry
    • Terms used in the solvent discussion
    • Classification of the solvents
    • Practical difficulties in meeting the residual solvents level
    • Green chemistry
    • Principles
    • Atom Economy
    • Greener ways of the preparation of some common chemicals
    • Solvent free reactions
    • Ionic liquids
    • Microwave synthesis
    • PMI ( Process mass Intensity )
    • conclusion
    Contents
  • 3. List of class II solvents The Solvent levels should to be screened through the chromatographic method & Quantified in the Final API
  • 4. Genotoxic carcinogens Carcinogens which are produces cancer by the affecting the genes are or chromosomes Nurotoxicity The ability of a substance to cause adverse effect on the nervous system PDE: Abbreviation for permitted daily exposure
  • 5. LIST OF CLASS III SOLVENTS Since the solvents are class-III the accepted limit is LOD NMT 0.5% in Final API .No need of the chromatographic method or Quantification.
  • 6. Class II solvent for which no toxicological data available . Due to the non availability of the toxicological data the manufacturer should give the Justification for the usage & the residual solvent levels of the above solvents in the final API.
  • 7.  
  • 8.
    • Preferably all the reactants & reagents used should be the RSMS
  • 9.  
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  • 22. GREEN ROUTES FOR THE SYNTHESIS OF THE COMMON CHEMICALS
  • 23.  
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  • 26. IONIC LIQUIDES
  • 27. Enantioseletive robinson annulation Solvent free Reaction
  • 28. Neat reactant Witting olifination
  • 29. Pyridenes synthesis
  • 30. Synthesis of the 3-coumarins
  • 31. Chemoseletive aldol condensation
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  • 51. Conclusion Green chemistry Not a solution to all environmental problems But the most fundamental approach to preventing pollution.
  • 52. Thank you

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