Solvents  in the pharmaceutical use  & The  Green chemistry
<ul><li>Solvents </li></ul><ul><li>Solvent chemistry </li></ul><ul><li>Terms used in the solvent discussion  </li></ul><ul...
List of class II solvents The Solvent levels  should to be screened through the chromatographic method  & Quantified  in t...
Genotoxic carcinogens Carcinogens which are produces cancer by the affecting the genes are  or chromosomes Nurotoxicity  T...
LIST OF CLASS III SOLVENTS Since the solvents are class-III  the accepted  limit  is  LOD NMT 0.5% in  Final API .No need ...
Class II solvent for which  no toxicological data available .  Due to the non availability of the toxicological data the m...
 
<ul><li>Preferably all the reactants & reagents used should be the RSMS </li></ul>
 
 
 
 
 
 
 
 
 
 
 
 
 
GREEN  ROUTES FOR THE SYNTHESIS OF THE COMMON CHEMICALS
 
 
 
IONIC LIQUIDES
Enantioseletive robinson   annulation Solvent  free Reaction
Neat  reactant Witting olifination
Pyridenes synthesis
Synthesis of the 3-coumarins
Chemoseletive aldol condensation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Conclusion Green chemistry   Not  a solution to all environmental problems  But  the most fundamental approach to preventi...
Thank  you
Upcoming SlideShare
Loading in...5
×

Green Chemistry-An overview

1,697

Published on

This is part of our in-house training programme where I had presented this.

3 Comments
2 Likes
Statistics
Notes
No Downloads
Views
Total Views
1,697
On Slideshare
0
From Embeds
0
Number of Embeds
3
Actions
Shares
0
Downloads
0
Comments
3
Likes
2
Embeds 0
No embeds

No notes for slide

Green Chemistry-An overview

  1. 1. Solvents in the pharmaceutical use & The Green chemistry
  2. 2. <ul><li>Solvents </li></ul><ul><li>Solvent chemistry </li></ul><ul><li>Terms used in the solvent discussion </li></ul><ul><li>Classification of the solvents </li></ul><ul><li>Practical difficulties in meeting the residual solvents level </li></ul><ul><li>Green chemistry </li></ul><ul><li>Principles </li></ul><ul><li>Atom Economy </li></ul><ul><li>Greener ways of the preparation of some common chemicals </li></ul><ul><li>Solvent free reactions </li></ul><ul><li>Ionic liquids </li></ul><ul><li>Microwave synthesis </li></ul><ul><li>PMI ( Process mass Intensity ) </li></ul><ul><li>conclusion </li></ul>Contents
  3. 3. List of class II solvents The Solvent levels should to be screened through the chromatographic method & Quantified in the Final API
  4. 4. Genotoxic carcinogens Carcinogens which are produces cancer by the affecting the genes are or chromosomes Nurotoxicity The ability of a substance to cause adverse effect on the nervous system PDE: Abbreviation for permitted daily exposure
  5. 5. LIST OF CLASS III SOLVENTS Since the solvents are class-III the accepted limit is LOD NMT 0.5% in Final API .No need of the chromatographic method or Quantification.
  6. 6. Class II solvent for which no toxicological data available . Due to the non availability of the toxicological data the manufacturer should give the Justification for the usage & the residual solvent levels of the above solvents in the final API.
  7. 8. <ul><li>Preferably all the reactants & reagents used should be the RSMS </li></ul>
  8. 22. GREEN ROUTES FOR THE SYNTHESIS OF THE COMMON CHEMICALS
  9. 26. IONIC LIQUIDES
  10. 27. Enantioseletive robinson annulation Solvent free Reaction
  11. 28. Neat reactant Witting olifination
  12. 29. Pyridenes synthesis
  13. 30. Synthesis of the 3-coumarins
  14. 31. Chemoseletive aldol condensation
  15. 51. Conclusion Green chemistry Not a solution to all environmental problems But the most fundamental approach to preventing pollution.
  16. 52. Thank you

×