State of Israel
      Ministry of Industry, Trade & Labor
      Investment Promotion Center

      Invest In Israel
Where ...
Main Economic Indicators
Criteria                                    2005          2006          2007          2008

GDP (...
Highlights

 Highest civilian R&D expenditure/GDP (4.7% of GDP)
 Largest number of scientists per capita in the world and
...
Israel’s Competitive Edge – IMD World Report 2008
                 Country Rank         1st          2nd           3rd    ...
Acquisitions of Israeli Life Science Companies
   Acquirer         Amount($M)    Company              Sector            Da...
Foreign Companies Invested in Israel - Some Examples
           US                     Europe                  Asia

 •   ...
Israel Life Sciences Cluster                                              Leading
                                        ...
Israel’s Life Sciences Industry
Israel’s Life Sciences Industry
Blockbuster Launched Products
Blockbuster Launched Product...
Israel’s Life Sciences Industry – Sectors
                     Medical IT 5%   Services 2%    Other, 2%
       Agro Biotec...
Main Medical Fields
90
80
70
60
50
40
30
20
10
 0




           Source: ILSI Database – 2009   10
Medical Device Patents per Million Capita 2007
 18
 16
 14
 12
 10
  8
  6
  4
  2
  0
      United   Japan Germany United...
BioPharma Patents per Million Capita - 2007




            Source: www.uspto.gov, Analysis: ILSI ©   12
Major Therapeutic Areas:

 CNS – Four Blockbuster drugs in market (Copaxone,
 Rebif, Exelon, Azilect)
 5 Additional drugs ...
Israeli Biotechnology Innovations

 Can-Fite has developed a platform technology that targets the A3
 Adenosine Receptor f...
Israeli Medical Devices Breakthroughs

Given Imaging - 1st ingestible video camera used to view
the small intestine and di...
Israeli Medical Devices Breakthroughs (II)
The Philips Brilliance CT scanner, developed in Israel takes
a comprehensive pi...
Stem Cells

• Israel is one of the world centers for stem cells
  research and technology development.

• The Jewish relig...
Summary
 Israel is a center of innovation and technological
 excellence
 Israel is a source for profit driving innovation ...
State of Israel
           Ministry of Industry, Trade & Labor
          Investment Promotion Center


 5 Bank Israel St.,...
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Israel Creating Synergies in Life Sciences

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INVENT, INNOVATE, INVEST ISRAEL LIFE SCIENCES..FOR BETTER LIFE

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Israel Creating Synergies in Life Sciences

  1. 1. State of Israel Ministry of Industry, Trade & Labor Investment Promotion Center Invest In Israel Where Breakthroughs Happen Creating Synergies in Life Sciences
  2. 2. Main Economic Indicators Criteria 2005 2006 2007 2008 GDP (current prices in $B) 133.2 144.0 164.1 199.4 GDP Real Growth Rate (%) 5.1% 5.2% 5.4% 4.0% GDP per Capita (PPP adjusted) $23,206 $24,271 $27,395 $28,473 GDP per Capita Growth Rate 3.3% 3.3% 3.5% 2.1% (%, Current prices) Exports (Goods & Services in $B) 57.2 62.6 71.2 80.4 (As Percentage of GDP) (43.0%) (43.5%) (43.4%) (40.3%) Imports (Goods & Services in $B) 57.5 62.2 74.0 84.1 (As Percentage of GDP) (43.2%) (43.2%) (45.1%) (42.2%) Unemployment Rate (%) 9.0% 8.4% 7.3% 6.1% Sources: Bank of Israel, Ministry of Finance, International Monetary Fund 2
  3. 3. Highlights Highest civilian R&D expenditure/GDP (4.7% of GDP) Largest number of scientists per capita in the world and dedicates one third of its research budget to the Life Sciences. First in the world for Medical Device Patents per Capita, Fourth for Bio-Pharma Patents. Fourth in investments in Biotechnology/GDP Rated 3rd worldwide in Medical Device area More than 18 drugs in advanced clinical trials (3rd in Europe) 3
  4. 4. Israel’s Competitive Edge – IMD World Report 2008 Country Rank 1st 2nd 3rd 4th BUSINESS EXPENDITURE ON R&D Israel Sweden Japan Korea TOTAL EXPENDITURE ON R&D Israel Sweden Finland Japan AS A PRECENTAGE OF GDP AVAILABILITY OF QUALIFIED Singapore Israel Chile Taiwan ENGINEERS KNOWLEDGE TRANSFER BETWEEN Singapore Israel Switzerland U.S.A INDUSTRY AND ACADEMIA VENTURE CAPITAL AVAILABILITY U.S.A Hong Kong Israel Singapore INFORMATION TECHNOLOGY SKILLS Sweden Singapore Israel U.S.A RESILIENCE OF THE ECONOMY Australia Denmark Switzerland Israel Israel Ranks 20 Source: IMD World Competitiveness Yearbook - 2008 4
  5. 5. Acquisitions of Israeli Life Science Companies Acquirer Amount($M) Company Sector Date Medtronic 325 Ventor Medical Devices 2009 Alcon Inc. 180 Optonol Ltd. Medical Technology 2009 Abbott 123 Starlims Laboratory Information 2009 Laboratories Technologies Management Johnson & 447 Omrix Biotechnology 2008 Johnson St. Jude 300 MediGuide Medical Devices 2008 Nobel BioCare 95 AlphaBioTec Dental 2008 Sun Pharma 454 Taro Pharmaceuticals 2007 Boston Scientific 80 Ramon Medical Devices 2007 Kyphon 220 Disc-O-Tech Medical Devices 2006 5
  6. 6. Foreign Companies Invested in Israel - Some Examples US Europe Asia • Perrigo • Philips Medical • Sun Pharmaceutical • GE Healthcare • Ferring • Scigen • Johnson & Johnson • Merck-Serrono • Sony • Dentsply • British Telecom • Toyo Ink • Stryker • SAP • Fuji • Boston Scientific • Alcatel • Honda • Microsoft • Siemens • Sumitomo Trading • AOL Time Warner • Cable & Wireless • Nomura • Intel • Deutsche Telekom • Samsung Electronics • IBM • Telecom Italia • Daewoo • Cisco Systems • Generali • LG Group • Lucent • Nestle • Hyundai • 3Com • L’Oreal • Acer Computers • Hewlett Packard • Danone • Macronix • Motorola • Unilever • Winbond • Sun Microsystems • Vilmorin • Hutchison Telecomm • Google • Veolia • Jain Irrigation 6
  7. 7. Israel Life Sciences Cluster Leading Academic Seasoned VC Institutions Community & Research University Medical, Science Defense Students and Technology Postgraduates Spillover Successful Existing Availability of Corporate Immigration Life science Technology Human R&D Companies Infrastructure Capital Global Technological Life Science Incubators Firms Veterans Strong Hospitals and Innovative & Medical Centers Entrepreneurial Government Culture Support 7
  8. 8. Israel’s Life Sciences Industry Israel’s Life Sciences Industry Blockbuster Launched Products Blockbuster Launched Products Product Indication Company Revenues Academic Inventor Licensee Institute 2008 Copaxone Multiple Teva $M 2,260 Weizmann Michael Sela (glatiramer acetate) Sclerosis Institute Rebif Multiple Merck- Merck-Serono Weizmann Michel Revel beta- (interferon beta-1a) Sclerosis €M 1,331 Institute Exelon Alzheimer’s Novartis Hebrew Marta Rosin (rivastigmine tartrate) $M 815 University Doxil / Caelyx Cancer J&J Hebrew Alberto University Gabizon (Doxorubicin liposome) Schering- Schering- Plough $M 430 Hadassah Hospital Azilect Parkinson Teva $M 175 Technion Moussa Youdim (rasagiline ) Launched July 2006 Erbitux Cancer Merck- Merck-Serono €M 565 Weizmann Michael Sela 07- Institute Bristol- Bristol-Meyers Launched 07-2008 Squibb M$ 749 8
  9. 9. Israel’s Life Sciences Industry – Sectors Medical IT 5% Services 2% Other, 2% Agro Biotech 3% Pharmaceutical 12% Biotechnology 20% Medical Device 56% Companies’ Developmental Stage Other 5% Seed 26% Revenue 39% Clinical 18% Pre-Clinical 12% Source: ILSI Database – 2009 9
  10. 10. Main Medical Fields 90 80 70 60 50 40 30 20 10 0 Source: ILSI Database – 2009 10
  11. 11. Medical Device Patents per Million Capita 2007 18 16 14 12 10 8 6 4 2 0 United Japan Germany United France Canada Israel South Taiwan States Kingdom Korea Source: www.uspto.gov, Analysis: ILSI © 11
  12. 12. BioPharma Patents per Million Capita - 2007 Source: www.uspto.gov, Analysis: ILSI © 12
  13. 13. Major Therapeutic Areas: CNS – Four Blockbuster drugs in market (Copaxone, Rebif, Exelon, Azilect) 5 Additional drugs in clinical stages Regenerative medicine & Cell Therapy (20 active companies, 4 in clinical trials) Cancer - Cell Therapy, Monoclonal Antibodies, Small Molecules, Image Guided Technologies Inflammation & Autoimmunity Cardiovascular Infectious diseases, Vaccines 13
  14. 14. Israeli Biotechnology Innovations Can-Fite has developed a platform technology that targets the A3 Adenosine Receptor for treatment of cancer and autoimmune inflammatory diseases. Gamida Cell is developing unique stem cells therapeutics, based on its proprietary stem/progenitor cells expansion technologies. Rosetta Genomics is a leader in the development of microRNA- based diagnostics and therapeutics BrainStorm Cell Therapeutics uses autologous bone marrow derived adult stem cells to combat Parkinson Disease. Cell Cure employs human embryonic stem cell technology for Parkinson. And …Biocancell(Gene therapy), BiondVax (Intra nasal vaccines for several flu strains), Compugen (threapeutic &diagnostic drug discovery) 14
  15. 15. Israeli Medical Devices Breakthroughs Given Imaging - 1st ingestible video camera used to view the small intestine and diagnose disorders Insightec - Image Guided HIFUS (High Intensity Focused Ultrasound) Medinol - pioneered the development of closed cell stent design and many additional innovations to the field of heart catheterization. GE Healthcare in Israel manufactured the world’s first miniaturized portable cardiac ultrasound system 15
  16. 16. Israeli Medical Devices Breakthroughs (II) The Philips Brilliance CT scanner, developed in Israel takes a comprehensive picture of a patient in seconds instead of minutes. Galil Medical - Cryotherapy for minimally invasive targeted ablation Insightec - MRI guided non-invasive surgical procedure And many more… 3D Endoscope • 3D Dental Mapping • Fixed non-cooled Magnet Open MRI • Simulators for Medical Procedures • Labor Monitoring • NiTiNOL Tooling • Intravascular miniaturized MRI imager • Spectral Imaging Device • Various Stents • Revolutionary Rectoscope • Implantable Insulin Generator • 16
  17. 17. Stem Cells • Israel is one of the world centers for stem cells research and technology development. • The Jewish religion does not hinder stem cell research – unlike in other cultures - a significant plus. • Israeli scientists are the most prolific authors on a per capita basis of published articles related to stem cell research. • There are about 20 companies actively engaged in this new industry. 17
  18. 18. Summary Israel is a center of innovation and technological excellence Israel is a source for profit driving innovation in the fields of Medical Technology and Bio-Pharma Foreign companies can conduct cutting edge research in Israel cost effectively . Favourable government support programs: Investment grants, Tax benefits and R&D grants Invest in Israel’s main purpose is to assist investors establish a presence in Israel. Please contact us. 18
  19. 19. State of Israel Ministry of Industry, Trade & Labor Investment Promotion Center 5 Bank Israel St., Kiryat Ben-Gurion Jerusalem, Israel www.investinisrael.gov.il investinisrael@moital.gov.il Tel: +972-2-6662607 Fax:+972-2-6662983
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