Breakthrough August 2012

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Breakthrough August 2012

  1. 1. breakthrough August 2012 | Issue 20 More than 200 guests attended the glittering second annual Garvan Gala black-tie dinner. The spectacular evening raised approx. $400,000 for the John Shine Translational Research Fellowship Fund at Garvan. See page 7 for the full story.Making NEWSLosing six kilograms reduces artery stiffness by 20 percent in obese people with Type 2 diabetes. Diabetescarries a six-fold greater risk of heart disease due toatherosclerosis, or hardening of the arteries. Garvan’sAssociate Professor Katherine Samaras and AssociateProfessor Christopher Hayward from St. Vincent’sHospital have shown that arterial stiffness is directlyassociated with inflammation – that is, activation ofwhite blood cells and genes that regulate inflammation.Garvan researchers Dr Lowenna Holt, AssociateProfessor Greg Cooney and Professor Roger Daly haveidentified a gene that regulates muscle size, a findingthat could help unlock therapies for Type 2 diabetes Inside this issue:and diseases such as muscular dystrophy, where From the CEO 2muscles are weakened and damaged. While researchingways to improve the response of muscle to insulin, Opinion 2they observed that a particular strain of genetically Garvan Australian Spectacular 3modified mice – missing the Grb10 protein – had largemuscles. Even newborn mice missing Grb10 had larger Toongi Country Gardens Weekend 3muscles, indicating that this protein regulates muscledevelopment before birth. Understanding the brain 4 Staff profile: Romain Rouet 6A biological phenomenon known as ‘somaticreversion’ – when an abnormal gene spontaneously Team Phil 6becomes normal again – explains why some patients Ask Garvan 7with a rare immunodeficiency known as X-linkedlymphoproliferative disease (XLP) live much longer Garvan Gala 7than expected. Many XLP patients die before theyreach 10 years of age, and the majority have a life Diagnosis leads to 13-years of service 7expectancy of less than 40 years. However, Garvanresearchers Dr Umaimainthan Palendira and Associate Clinical studies 8Professor Stuart Tangye discovered that a substantial Coming up 8percentage lived much longer than expected, evenapproaching the age of 50. In memoriam 8
  2. 2. breakthrough August 2012 | Issue 20 3From the Garvan Australian SpectacularCEOThe past few months have been an excitingperiod for Garvan. As well as importantbreakthroughs that you can read about in this Opinion lives up to its name The inaugural Garvan Australian Spectacular was held at the beautiful Sydney Town Hall on Saturday 28 April. Comedian Paul Martell did an outstanding job as MC,issue, we have been fortunate to have had and kept the audience in stitches. Talented performerssome of the world’s very best scientists and included The Sydney International Orchestra; Theresearchers visit the campus to share insights. Australian Army Band, Sydney; VOX – The SydneySome of the major visitors were Professor Philharmonia Youth Choir; Jane Scali; Scott Radburn; Medical research institutes Erin James, The Macquarie Singers; Adam Scicluna, andJohn Stamatoyannopoulos from the University and medical scientists are Jenny Liu. Young performers Harry Ward on violin, Brianof Washington (Seattle) Genome Center and motivated by the quest to cure Kim on flute and singer Fabian Andrés gave rousingProfessor Yehiel Zick and Professor Michael performances. or, preferably, prevent humanWalker from the Weizmann Institute of disease. In Australia and other The audience was also privileged to hear musicalScience, Israel. advanced countries, the defeat arrangements by the great Australian Maestro, DrA particular highlight was a visit by Professor of most infectious diseases Tommy Tycho AM MBE, who attended the concert.Elizabeth Blackburn, the first Australian means that the major health From classical and contemporary music, to opera andwoman to win a Nobel Prize, who gave a burden has switched to the comedy, through to the stirring patriotic finale that leftlecture particularly aimed at engaging with the audience with goose bumps – the Garvan Australian more complex diseases likehigh school students considering a career in Spectacular really did have something for everyone. cancer, osteoporosis andscience. She gave her talk, ‘From Tasmanian We would like to sincerely thank the organising committee – Dr Steve Watson, Ken Laing AM and especially Pauline Cash neurodegenerative diseases that,Schoolgirl to Nobel Laureate’, to a packed Cumming, as well as all performers, staff and volunteers who gave so generously to make this concert such a success. regrettably, increase with age.Garvan Auditorium made up of school Funds raised at the Garvan Australian Spectacular were donated to the Garvan Institute of Medical Research.students from across NSW and Garvan The fact is, we usually have to Professor John Mattick AO FAA Toongi Country Gardensresearchers – all of whom left inspired. Executive Director understand a disease before we can work out how to stop it.Of course, a major ongoing highlight hasbeen to see The Kinghorn Cancer Centre This was true in cancer where, over the past 30 years, identifying Weekend – A Blooming Successsteadily rise from the ground as it approaches the genes that are mutated in cancer was the prerequisite tocompletion, ready for occupation by both the development of drugs to block them. The same is true ofGarvan researchers and clinicians from St osteoporosis – a silent killer, as many people die within monthsVincent’s. As this issue goes to print, we will to a few years of a major fracture, yet we don’t know who will die In October, a hard-working committee of localsbe rapidly approaching our opening date of or why. However we do know that treatment reduces the risk of including Fay and Jim Pascoe, Bill and Lesley Hyland,28 August 2012. fractures and of premature death. We need to find out whom we Phil and Sue Sheridan, Carolyn Pascoe, Graeme need to target. Coddington, Kim Job and Janet Watters organised aThe Kinghorn Cancer Centre – like much of the fundraising weekend in the Toongi area of Dubbo.work undertaken here at Garvan – takes place The trouble is, we do not yet understand the origins of osteoporosisthanks to the generosity of the general public. or neurodegenerative diseases like Parkinson’s and Alzheimer’s The Toongi Country Gardens Weekend saw four magnificent country gardens open to the public, some disease. We also do not have a good understanding of how boneThank you for your ongoing support. for the very first time, with stalls strongly supported by strength is regulated, nor how the brain functions.Yours sincerely, local retailers providing country morning and afternoon Garvan has major research programs in these areas, and a team teas, crafts and all things gardening, as well as talks byAndrew Giles well-known gardening experts. of extraordinarily gifted and dedicated individuals who spendGarvan Research Foundation most of their waking hours wrestling with these questions. We The breathtaking gardens on display included the take a strategic approach that, on the one hand, investigates Pascoe’s at Cranbrook which is a majestic AustralianProfessor Elizabeth Blackburn talks with students fromWenona School. promising leads in the hope of making immediate improvements in country garden. The ‘disappearing spaces’ at the diagnosis and treatment while, on the other, tries to understand the Sheridan’s garden at Tralee were a hit. The Hyland’s at Karingle impressed with their spectacular roses, and The fundamentals of the processes involved, giving insights and clues Coddington’s at Eulandool have brought the original for the future. 1920’s garden back to life. I hope that you will join us by supporting both targeted projects and The committee, plus staff from Garvan’s Dubbo Standing L to R: Committee members Jim Pascoe, Carolyn Pascoe, Kim Job, Graeme our efforts in the underpinning science. Sometimes progress seems Coddington. Seated: Lesley Hyland and Sue Sheridan. With cheque: Professor John Osteoporosis Epidemiology Study (DOES), and volunteers Eisman and Fay Pascoe. frustratingly slow, but we can take heart from the extraordinary worked tirelessly to raise almost $30,000 for DOES. pace of change. It is only just over 200 years since the first atomic Of this terrific fundraising initiative, the Garvan Institute’s Professor John Eisman said, “The Toongi Country Gardens Weekend is table, and only 70 years – one lifetime – since the development of a wonderful way to let people see the beauty of the Toongi area, while raising much-needed funds for the vital work carried out penicillin. All we can say about the future is that things will change at the Garvan Institute and specifically, the internationally renowned Dubbo Osteoporosis Epidemiology Study. We are extremely faster than we think, but usually not in the way that we think. grateful to all involved for coming up with this idea, and giving so generously of their time and effort to make it a success.”
  3. 3. breakthrough August 2012 | Issue 20 5Feature story: Understanding the most institutions looking at, not only behavioural alterations in this disease, but also trying to uncover the basic, underlying mechanisms that helps us visualise where the gene is expressed in the brain and if it changes with different factors. fruit fly gene with similar function. Garvan researchers focus their efforts on these genes that are shared between fruit flies and people.complex organ in the human body – the brain cause the individual’s metabolism to change so Studies to date have deleted SNORD 116 in the Using this system, researchers have identified dramatically. Understanding how the brain is embryo. We will delete this gene in adult mice 600 new pain genes in the fruit fly, with most altered in anorexia will be a major step toward helping people with this devastating condition. to see if this increases the characteristics similar of these genes having mammalianGarvan’s Neurological Diseases Division aims to increase our understanding Garvan researchers are studying the significant to Prader-Willi. This might then give us a clearer understanding of the role of SNORD 116. counterparts. Our researchers are currently prioritising and confirming these genes.of fundamental processes in the brain and the neuronal systems involved in role of a specific brain peptide system in the Lastly, we want to see whether replacing the As an example, they have already identified regulation of energy balance and weightdisorders such as Parkinson’s disease, Alzheimer’s disease, schizophrenia, control. There is an intricate regulatory system gene in mice, when it has been removed, then a calcium channel sub-unit (a2δ 3) as part of that governs our appetite and energy intake. reverses the problem. If effective, this would the pain relay system in the brain. This workeating disorders and hearing loss. Certain proteins such as neuropeptide Y (NPY) offer an exciting potential therapeutic target in led to identification of the first ever gene enhance appetite and induce feeding, while people with Prader-Willi syndrome. shown to play a role in sensory cross activationRecently, the program has expanded its release and control of dopamine in the brain. At Garvan, we are taking a range of others, such as leptin, act as a satiety factor. or synesthesia – a condition that leads tointerests, also looking at how the brain Once the various mechanisms are known, we approaches to investigate Alzheimer’s disease. In summary, our studies will significantly sensations of one kind being perceived asinteracts with other organs in the body and, can develop a therapeutic approach to treat Our scientists are researching the mechanisms Garvan researchers are investigating the advance our understanding of the function another. For example, words or numbers mightfor example, how it controls bone formation, the disease and restore movement control. at the synapses (where one neuron makes a functional contributions of the NPY system in of SNORD 116, the primary gene involved in be perceived as colours. The number sevenas well as research into the human experience connection with another) that are important relation to the development and manifestation Prader-Willi. Exploring mice models of gene as the colour yellow. Colours could be heard Advances in whole genome and exome (the of anorexia. In particular, its role in triggering deletion and replacement will hopefully lead toof pain. This research aims to identify new in memory formation. We are trying to as music.therapeutic approaches in these areas, with genome’s exons, or the coding portion of taste aversion, commonly seen in this disorder. development of a potential therapeutic target understand if these mechanisms are somehowspecific interest in regenerating the nervous genes) sequencing techniques now make it for Prader-Willi syndrome. In collaboration with Professor Josef involved in contributing to the neuron dying in Furthermore, studies have also shown that asystem for therapeutic purposes. It also aims possible to identify disease-relevant genetic Penninger, while he Alzheimer’s disease. gut-derived hormoneto achieve a better understanding of the variants and non-coding RNAs associated was working at the called peptide YY (PYY) with sporadic and familial Parkinson’s disease. Recently, Garvan researchers demonstrated Institute of Molecularbrain’s control of body functions including which promotes satietythe regulation of energy balance (intake and This capability means Garvan researchers are a significant biochemical change in a protein Biotechnology of the in normal subjects isexpenditure), which can affect fertility, mood, in a position to use our expertise in areas like called CRMP2. This change appears to occur Austrian Academy of abnormally high inweight gain and physical fitness. gene discovery; the cell biology and molecular specifically in the brains of people with Sciences in Vienna, people with anorexia. biology of Parkinson’s disease; our access to Alzheimer’s disease, but not in other forms of Garvan was involved Apart from inducingIn this article, we highlight Garvan’s work in human Parkinson’s brain tissue; our cell and dementia. It also appears to occur early in the in screening the nausea, high PYY levelsParkinson’s disease, Alzheimer’s disease, eating animal models of Parkinson’s; and our expertise disease process, and has the potential to be a genome of fruit have also been founddisorders and pain research. We discuss some in drug discovery to advance the development biomarker for early and specific detection of flies to investigate to be associated withof Garvan’s recent findings in these areas, and of new therapeutic approaches for this disease. Alzheimer’s disease. pain perception – in decreased body weight,how these findings increase our understanding particular, the insects’ Although the sporadic form of Alzheimer’s body mass index andof the most complex organ in the human Another exciting research project involves bone composition in response to heatbody – the brain. seeing how we can harness the brain’s own disease has similar pathology to the familial people with anorexia. induced pain. They adult stem cells which normally function form, it is not yet clear if the causes of theParkinson’s disease disease are the same. We are particularly then honed in on a2δ 3, to repair injury to the brain and make new Garvan researchers interested in a new gene called Bin1 that is a gene also sharedIt is estimated that one in every 350 Australians nerve cell connections, to potentially help have shown that mice genetically associated with the predominant with mice and people.is living with Parkinson’s disease, and each day, treat Parkinson’s disease, as well as other with high levels of sporadic form of the disease. We have found The gene seems to30 more people are diagnosed. 1 neurodegenerative conditions. To do this, PYY have decreased it is controlled by an important brain enzyme hold promise because Garvan’s Adult Stem Cell Group studies neural fat and bone mass,The symptoms of Parkinson’s disease result called GSK3. Importantly, we have shown it triggers the same stem cells, isolated from the adult olfactory suggesting that the lossfrom the progressive degeneration of neurons that Bin1 is important for survival of neurons cellular mechanisms neuroepithelium (situated in the nose) and of body fat and bonein the midbrain. Neurons in this part of the in flies, suggesting that defects in GSK3-Bin1 tissue in young people as some existing grown in the laboratory in the form of olfactory painkillers.brain control the release of a neurotransmitter signaling could contribute to neuronal death in with anorexia may neurospheres. The aim is to identify, isolatecalled dopamine. Dopamine stimulates motor Alzheimer’s patients. We believe this provides be caused by these From a medical and propagate these cells to determine theneurons – nerve cells that control the muscles. a novel therapeutic strategy to help protect high circulating PYY research perspective, conditions needed to transform them into theWhen dopamine production is depleted, the neurons from dying and slow the rate of levels. Our aim now is these findings help different types of nerve cells found in the brain,motor system nerves are unable to control neurodegeneration. to determine whether explain the wide for example, those lost in Parkinson’s disease.movement and coordination. By the time methods to block PYY 2 variance in how peoplesymptoms appear, Parkinson’s disease patients 1 Alzheimer’s Australia – www.fightdementia.org.au levels in people with Parkinson’s Australia Inc – www.parkinsons.org.au experience pain. Nothave already lost 80 per cent or more of their Eating disorders (Anorexia nervosa and anorexia may have Pain research Alzheimer’s disease only that, they indicate potential ways ofdopamine-producing cells. Prader-Willi syndrome) beneficial effects in restoring body weight, treating acute and chronic pain in the future, Alzheimer’s disease is a degenerative condition body composition and food intake. It is thought that more than 50 per cent ofAlthough there are many theories about the by mimicking the effects of the mutated gene. Anorexia nervosa is an eating disorder the population will experience some formcause of Parkinson’s disease, so far none of the brain, characterised by the loss of Prader-Willi syndrome is a genetic cause of of unknown origin that most commonly of chronic pain within their life, especially From a neuroscience perspective, thishave been confirmed. A few cases have been memory and cognitive function. Although obesity, affecting children. Patients and families occurs in women and usually has its onset in patients that suffer from arthritis, cancer, research provides the first genetic insightshown to be inherited and have been traced there is no cure for Alzheimer’s disease yet, it are faced with the difficulties of coping with an adolescence. However, interestingly, before diabetes, migraine, or nerve injuries. Despite the into synesthesia, or crossing of the senses.to mutations in four different genes, including can be managed and the symptoms alleviated insatiable appetite, complications of obesity puberty, one in every four people with anorexia astonishing prevalence, there are few effective For example, the mice with the mutatedthe alpha-synuclein gene that Garvan is for a time. A person may live anywhere from and a myriad of other health problems. is male. After puberty, one in eleven is male, therapeutic options for these patients. gene experienced heat as other perceptionsinvestigating. three to twenty years with Alzheimer’s disease, although it is thought this ratio is increasing. In the last year, it has become clearer that a including vision, sound and smell. Using MRI with the average being seven years. One of the major goals of Garvan’s Neuro-PainGarvan’s researchers are taking a range of gene called SNORD 116 is primarily affected in scanning, researchers could see their brains Patients with anorexia have a disturbed Research Group is to identify and characteriseapproaches to Parkinson’s disease, particularly In 2012, it is estimated that more than the development of Prader-Willi. However, little lighting up in those areas. 2 body image and an intense fear of weight is known about the function of this gene and new genes that participate in the severity offocusing on researching the mechanisms 278,000 Australians are living with dementia. gain. Devastatingly, anorexia has a high how it might be involved in the regulation of chronic pain, with the aim to develop a next Garvan is hosting a free Neuroscience Publicbehind cell degeneration. Alzheimer’s disease is the most common mortality rate – 20 per cent eventually die as a appetite, growth and metabolism. generation of therapeutics for this debilitating Seminar on Thursday 20 September 2012. type of dementia, and presents in twoWe know that certain pesticides, toxins and consequence of the disease, and one in five will condition. Registration is essential. To secure your seat, forms – sporadic and familial. The sporadic Our team uses mouse models to explore whichgenes (such as the alpha-synuclein gene) attempt suicide. Currently, there is no definitive visit www.giving.garvan.org.au/seminars or form of the disease is usually diagnosed after areas of the brain SNORD 116 is concentrated in, To this end, Garvan researchers have developedcause Parkinson’s disease, but why they cause treatment for anorexia nervosa. phone (02) 9295 8110. the age of 65 and is by far the most common. and for the first time, we will study how factors a novel, systematic strategy for identifying newthe disease is not fully understood. In the less common familial form, the disease Not a great deal of research is dedicated to such as feeding and weight might regulate components of the pain pathway using theAnother aspect of Garvan’s research is runs in families and usually affects people aged uncovering the underlying mechanisms of its function. We will use a special staining fruit fly – Drosophila melanogaster. 70 per centinvestigating the mechanisms behind the in their 40s or 50s. anorexia. Garvan is one of the few research technique called in-situ hybridisation, which of human disease genes have an equivalent
  4. 4. breakthrough August 2012 | Issue 20 7 Garvan’s Glittering GalaStaff Profile: Romain Rouet Ask Garvan On Saturday 12 May, Garvan hosted its second annual Garvan Gala, raising more than $400,000 for the John Shine Translational Research Fellowship Fund at Garvan. we can even improve existing drugs Q: What is ‘translational research’? that are already on the market. With Held at the Overseas Passenger Terminal, with a spectacular more than 50 per cent of all new drugs A: Translation research sees scientific discoveries view of the harbour and the Sydney Opera House, VIP guests resulting from laboratory, clinical, or population studies, included The Hon. Tanya Plibersek MP – Federal Minister for being antibodies, our work has the transformed into clinical applications that will reduce Health and Ageing, and The Hon. Jillian Skinner MP – NSW potential to dramatically improve how Minister for Health and NSW Minister for Medical Research. we develop targeted therapies. incidence, morbidity and mortality of disease. Guests were entertained throughout the evening by the MC, What do you enjoy doing away from The Kinghorn Cancer Centre, which is due to open Walkley Award winning journalist Annabel Crabb, while they the lab? in just a few weeks, will be an excellent example of dined on an exquisite menu designed by Neil Perry. Award- this translational research (also known as ‘bedside to winning soprano Greta Bradman made her way through the I try to spend time exploring Sydney bench’) approach to cancer. room, thrilling guests with her outstanding performance. and the rest of Australia. It is really a When it is fully operational, the 250-plus researchers Throughout the evening, guests had the chance to win a vast beautiful country with many different and clinicians working in this purpose-built cancer array of wonderful prizes. Many purchased a key to try and open landscapes. I have visited Queensland, a locked box containing a Paspaley South Sea Pearl Marquise Western Australia, Tasmania and now centre will ensure that challenges faced in the clinics will Pendant with Tanzanite and Pave Set Diamonds in Platinum on a intend to go to the Northern Territory. drive laboratory research, and that laboratory research Paspaley White Gold Chain, valued at $8,560. They also had the findings are applied quickly back into clinical care. chance to guess the number of Lindt balls in a jar – the prize, of Leonard Harlan (left) and Howard Morgan I also enjoy running. I try to do a few As well as state-of-the-art clinical and consulting rooms course, being the jar filled with 877 Lindt balls! (right) present Romain Rouet (centre) races every year and this year, I hope with the 2011 Castle Harlan Award. to help the Garvan Chang Giants win and laboratories, the centre will provide workspaces The exciting live auction featured fabulous prizes, including: the next City2Surf team competition. and meeting rooms so that researchers and clinicians • The John Singleton Experience’ – helicopter flights, private ‘What is the current focus of your work? What are some of the recent findings can come together into multidisciplinary teams to tours, meals and a night’s accommodation at a number of Mr of your work? Last year, you won the Castle Harlan Singleton’s spectacular properties;I am a PhD student and member of the exchange information and ideas about the diagnosis, Award. How has this benefited you andAntibody Engineering laboratory at the I have been able to identify key treatment and care of cancers. • Lunch with Michael Clarke’ aboard the luxury cruiser, Ghost II; ‘ your work?Garvan Institute (under the supervision residues within antibodies that control • Neil Perry cooking for a dinner party of ten in your home;of Dr Daniel Christ). Antibodies are stability and tendency to aggregate. Thanks to the Castle Harlan Award, I • A Leo Robba original artwork; andeffector molecules the immune system Moreover, together with my colleagues, was able to attend the PEGS Protein • wo return business class QANTAS tickets to either London or Tproduces to fight bacteria and viruses.However, in recent years they have also I have been able to develop a general strategy to overcome this problem. This Engineering Summit 2012 in Boston (USA) in May. This is one of the key Life-saving diagnosis leads New York, including five nights at a luxury Accor five star hotel. to 13-years of service protein engineering conferences, with The Silent Auction also generated excited bidding for prizesbeen increasingly used as drugs by has created a lot of excitement and has including:changing their specificity to kill cancer recently been published in Proceedings talks from leaders in the field. I was able to meet them, talk about their work and In 1997, Graham Curtis was • A luxury Thailand getaway;cells and to reduce inflammation. of the National Academy of Sciences, which is the official journal of the US the challenges they faced. diagnosed with acromegaly, • pening night tickets to Madama Butterfly (Opera Australia); OIn the Antibody Engineering laboratory a debilitating disease most • pening night tickets to Signs of Life (Sydney Theatre O Academy of Sciences. In addition, I also started looking forwe have two major aims: to generate commonly caused by a non- Company);new anti-cancer antibody drugs and What is the biggest challenge in your potential post-doctoral positions. I cancerous tumour on the will also visit industry collaborators in • ickets and limousine transfers to the Bledisloe Cup at ANZ Tto identify strategies to increase area of research? pituitary gland. Stadium;their stability. I mainly work on the Cambridge (UK) in September. They The biggest challenge is really to It was while under the care • ickets and limousine transfer to see Lady Gaga at Allphones Tsecond aspect – stability. This is a have an extensive range of equipment find a general approach to target of Endocrinologist, Professor Arena; that is not necessarily available in anmajor problem for the pharmaceutical aggregation – a strategy that suits Ken Ho who, at the time was academic environment. I plan on doing • An experience in a QANTAS flight simulator; andindustry, which is currently unable to most antibodies, independent of their head of Garvan’s Pituitary experiments there, to supplement our • framed, colour print of the winner’s DNA profile, to name Atake many promising drugs forward specificity. Maintaining activity – the Research Unit, that Graham current work at Garvan. a few.because of poor stability. The drugs interaction with the antigen is the other first became aware ofsimply “crash out” of solution and form Garvan’s work. Mr Graham Curtis Raffle prizes included trips to Hayman Island and Sheraton major hurdle. We have been able to Mirage on the Gold Coast; lunch at Bathers Pavilion; RM Williamsinsoluble aggregates. show that our method is so powerful, “Professor Ho encouraged me to attend one of Garvan’s boots; Dinosaur Designs homewares; a box of Arras Tasmanian free public seminars. I was very impressed. At the sparkling wine; a year’s supply of Movenpick ice cream; a total end, I filled in a questionnaire and said I’d be interested Lindt experience, and a luxury hamper from Hampers Only. in volunteering.” That interest resulted in 13-years of Sincere thanks must go to all the generous sponsors andTeam Phil – Doing the hard yards for dedicated service. “My motivation was simple. I felt that by volunteering supporters who donated these wonderful prizes for the event.Pancreatic Cancer Research at Garvan, I was in some way paying back Professor Ho and his team for saving my life. It was my way of returning the favour.”In 2011, a group of runners calling themselves ‘Team Phil’ competed in the Melbourne Marathon Festival. They participated in It is this same motivation that has led Graham to alsomemory of Philip Hemstritch, and many others who have lost their battle with pancreatic cancer. They raised an extraordinary become a Garvan ‘Partner for the Future’ – one of a special$79,611.98 for Garvan’s pancreatic cancer research program, including its lead role in the Australian Pancreatic Cancer group of people who have left a gift to Garvan in their will.Genome Initiative. “There’s not a great deal of research being done intoTeam Phil’s outstanding effort has led to the establishment of The Philip Hemstritch Fellowship in Pancreatic Cancer Research. pituitary disorders, so I would particularly like my bequestThis three-year Fellowship has recently been awarded to Garvan’s Dr Marina Pajic, a promising early career scientist. to assist Garvan’s efforts in this area.”Team Phil will again be competing in the Melbourne Marathon Festival on 14 October 2012. To join Team Phil, or for more To find out more about becoming a Garvan ‘Partner for the L-R: Garvan Research Foundation CEO Mr Andrew Giles, Executive Directorinformation, email jane.hemstritch@mac.com Future’, contact Carol O’Carroll on 02 9295 8117, or email of the Garvan Institute Professor John Mattick AO FAA, Garvan Gala MC Ms Annabel Crabb, Garvan Research Foundation Chairman Mr Geoff Dixon, and c.ocarroll@garvan.org.au Chairman of the Garvan Institute Mr Bill Ferris AC.
  5. 5. Clinical Studies In Memoriam March – JuneStudy on Fat Metabolism 2012. Donations have beenWe are looking for healthy volunteers: men and postmenopausal women, aged50-70 years for research into hormones and body fat. This study involves visits made in memory of:over a 14 week period to the Garvan to study the effects of three commonly used Gordon Adamson Wendy C Green Katherine Smedications, oestrogen (women only), letrozole and tamoxifen on the burning of Roger Anderson Neil Greive Mignotfat in the body. We will investigate how fat is utilised at whole body and liver level. Ludek Molik Secundino Wallace GrigorFor further information please contact Dr Vita Birzniece (02) 9295 8483, Arguelles Graeme S Guy Timothy P Morathv.birzniece@garvan.org.au or Vanessa Travers (02) 9295 8232, Maureen Aronson Jean B Hale Adrian Notleyv.travers@garvan.org.au (St Vincent’s Human Research Ethics Ref No 09/090). Rona Barlow Bonnie Hansen Frank OrganMetabolism – Genetics of Obesity Study Mr Bob Bauza and Julie Harmer Noel PearceDo you think you could be overweight? Volunteers are needed to screen for a Dr Margaret Dunngene that links to obesity at the Garvan Institute. It involves only one visit during Thomas H Hill Pericles Patricia Beagleywhich measurements and a blood test will be taken. If you are suitable, you may Stuart J Hoy Pertsinidisenter the second part of the study to receive a full metabolic assessment. Helene Bell Beatrice Humbley Nicholas PhilipFor further enquiries, please contact Dr Daniel Chen (02) 9295 8557 or Edgardo Bertinat Elizabeth Iskandar Daphne Pictond.chen@garvan.org.au, or Jen or Renee, (02) 9295 8215, j.evans@garvan.org.au Peter Boersma(St Vincent’s Human Research Ethics Ref HREC/10/SVH/133). Hans Janota Leonard N Price Valerie Bulluss Gordon T Jesson Tracey PurcellPre-diabetes study Annabel Catt Cecily Judge Brian QuintonWe need healthy volunteers for a study looking at the effects of immune function Antonio Colosiand autonomic nervous activity in Type 2 diabetes. We especially need people Elli Kadner Robert J Rice Kennethwith a family history of Type 2 diabetes. Coppleman Philip Kelly Patricia A RickettsIf you are willing and are aged 50 to 60 years and healthy, please contact Roy Kester Michael E Cordner Stefan SerbanLynne (02) 9295 8231 or Dorit (02) 9295 8309 or email crf@garvan.org.au Maria Corrente Margaret Keyvar Noeleen Shaw(St Vincent’s Human Research Ethics Ref 06/147). Suann Croker Dianne Knight Miloslava Sicha Joseph Delia Zelma Lawrence Wendy SinclairComing Up Malcolm J Denner Joan Lee Peter Skord Salvatore Di Campli Barbara Leedham18 August – Young Garvan All Ribbons Ball. Hilton Hotel, Sydney. Kay M Smith San Vito Janette LeggoVisit www.allribbonsball.com Richard Smith Lesley Dixon20 September – Free public seminar – Alzheimer’s disease and other Tim and Andrew Francisco Solarneurodegenerative disorders. 10am to 12 noon. Registration is essential. Sue Dowlan Lynch Mrs MacQueen Louise Speiler Tony Edwardson14 November – Free public seminar – Type 2 diabetes and obesity. Beryl G Forbes Peter Male James Van Rol10am to 12 noon. Registration is essential. Susan Gamble George Massey Maureen WestonFor more information about any of these events, visit www.giving.garvan.org.auor phone (02) 9295 8110. Douglas Giles Philip McAlpine Greg Wilson Len Goldsboro Chris McElhinny John Wright Please use this coupon if you would like to make a donation to Be part of progress Garvan’s breakthrough medical research, or if you would like further information. We would love to hear from you. My Contact Details My Gift Details Title First Name Yes! I want to help Garvan make progress with a gift of Surname $50 $100 $250 $500 $1000 Gift of choice $ Address M y cheque/money order made payable to Garvan Research Foundation is enclosed Suburb State Postcode OR Please deduct the above amount once monthly annually Daytime Phone from my Visa MasterCard Amex Diners Email Card Number Garvan Supporter Number (if known) / Expiry Date 2012BT02 Please Send Me Further Information About: Cardholder’s Name Giving to Garvan in my will (strictly confidential) Signature Volunteering with Garvan Donations of $2 and above are tax deductible. Giving regularly to Garvan through my bank account Please complete this coupon and mail it to: Please Change My Communications: Garvan Research Foundation Reply Paid 68593, Darlinghurst NSW 2010 I no longer wish to receive this breakthrough newsletter Call: 1300 73 66 77 (9am to 5pm) I only wish to receive breakthrough by email Fax: (02) 9295 8507 I only wish to receive appeal mailings in May/June (you can use this coupon) I do not wish to receive any appeal mailings Online: www.giving.garvan.org.au

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