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Garvan breakthrough_dec_issue

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December issue of breakthrough

December issue of breakthrough

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  • 1. breakthrough December 2011 | Issue 18 Professor John Mattick AO FAAThe Garvan Institute of Medical Image courtesy of Paul Harris, seesaw photographyResearch recently announcedthe appointment of ProfessorJohn Mattick AO FAA as theInstitute’s next Executive Director,following the retirement of ProfessorJohn Shine AO FAA.Professor Mattick will begin histenure at Garvan in January 2012,and is taking every opportunity in thelead-up to his arrival to meet Garvanstaff, board members and supporters.Read more about Professor Mattick,his impact on medical research, andhis hopes for his time at the Garvanon page 5.Making NEWS‘Brown fat’ is believed to be a wondrous tissue that burnsenergy to generate heat, that could help us fight obesity.We are obese when we have too much ‘white fat’, whichis basically an organ of energy storage. In contrast, brownfat is like a heat generator. Around 50g of white fat stores300 kilocalories of energy. The same amount of brownfat burns 300 kilocalories a day. Garvan researchers haveshown that brown fat can be grown in culture from stemcells biopsied from adults – giving hope that one daywe might be able to either grow someone’s brown fatoutside the body and then transplant it, or else stimulateits growth using drugs. Read moreIdentical twins have identical genomes, but that is whereit stops. There are subtle differences in their personalities,how they look, how they act and in their susceptibility Inside this issue:to disease. How can this be? According to scientists From the CEO 2from Garvan and Queensland Medical Research Institute,it all depends on how the “epigenome” is modified Opinion 2by the environment. More specifically, it depends on Garvan welcomes Professor John Mattick 3exactly how particular parts of the genome are affectedby ‘methylation’, or the attachment of hydrocarbon Cures can take more than a lifetime 4molecules - ‘methyl groups’, that literally changethe voice of the genome, silencing some genes and Type 2 diabetes 5amplifying others. These findings are based on an eight- Staff profile – Dr Ann McCormack 6year study involving 512 adolescent twins (128 identicaltwin pairs, as well as 128 non-identical twin pairs), with an Fundraiser profile – ‘Team Phil’ 6average age of 14.15 years. Read more Ask Garvan 7Garvan scientists have discovered that a single gene First glimpse inside the Kinghorn Cancer Centre 7controls a very complex process, apparently forming thecrucial link between eating a high fat diet and developing In memory of a remarkable man 7diabetes. Compounds are already being developed Clinical studies 8for blocking the gene – known as Id1 – as it has knownadverse effects in cancer. This drug development work Coming up 8would very much shorten the path from discovery toprospective treatment in the case of Type 2 diabetes. In memoriam 8 Read more
  • 2. breakthroughFrom theCEOWelcome to the final issue of breakthrough Opinionfor the year. As you will read, we have somevery exciting news with the appointment ofour new Executive Director, Professor JohnMattick AO FAA who is joining us early in As I retire as Executive Director at the end of the year, I2012. Professor Mattick has an outstanding take this opportunity to reflect on the past 20 years at thisreputation as one of Australia’s leading remarkable institution. I have been extremely privilegedscientists and will bring a wonderful range to be at the Garvan and to witness firsthand the manyof skills to the Garvan. exciting research discoveries that have emanated fromI am sure that many of our supporters will be the institute. It clearly is an institute that should make alldelighted to know that our current Executive Australians very proud and I have been continually humbledDirector, Professor John Shine will not be by observing every day the generosity of our supporters andgoing very far way – in fact, he won’t even the dedication, intelligence, creativity and commitment of allbe leaving the building! Professor Shine the staff. While we all appreciate our good fortune workingwill return to the lab to further pursue his in research, we are all very aware of the responsibility thatpassion for medical research. comes with it – to ensure that the critical trust and supportAs the year draws to a close, it is wonderful of our community is honoured by a focus on producing theto look back at some of the amazing very best research and a focus on delivering improved healthbreakthroughs that have been made here outcomes for all.at Garvan in areas as diverse as pancreatic Although the past 20 years has seen amazing progress,cancer, childhood deafness, asthma and the next decade promises even more. The Garvan has beenType 2 diabetes (to name a few!) most fortunate to attract Professor John Mattick as the nextThe year has also been great personally Executive Director. John is an outstanding Australian andfor some of our researchers who have won an international leader in the analysis and understanding ofprestigious awards. Congratulations to Dr the human genome – the area which is truly bringing us intoAlex Swarbrick who received the Cancer the era of personalised medicine. Under John’s leadershipInstitute of NSW’s 2011 Premier’s Fellow of and with your ongoing support, the exciting growth plannedthe Year Award and Dr David Chang who for Garvan (the first example being the Kinghorn Cancerreceived the CINSW 2011 Premier’s Scholar Centre), will rapidly come to fruition.of the Year Award, as well as a PfizerOncology International Studentship.To all our wonderful supporters – thank youfor helping Garvan continue its vital, world-class work in 2011, and we look forward toyour ongoing support in 2012.My best wishes to you and your loved onesfor a safe and enjoyable festive season.Yours sincerely,Andrew GilesGarvan Research Foundation Professor John Shine AO FAA Executive Director
  • 3. December 2011 | Issue 18 3Welcome:Professor John Mattick AO FAAGarvan welcomes new “After heading IMB and its forebear forExecutive Director, 18 years, I realisedProfessor John Mattick that I had three big jobs. I was running anAO FAA institute of over 400Professor John Mattick, holder of people. I had researcha prestigious NHMRC Australia I wanted to pursue,Fellowship at the University of because I thought IQueensland and the inaugural had seen somethingDirector of the University’s Institute nobody else had - thatof Molecular Bioscience (IMB), has human genetics had been misunderstoodbeen appointed as Garvan’s new for the past 50 years. IExecutive Director. also had an extremelyProfessor Mattick is excited to be supportive family thatjoining Garvan, which he considers I wanted to give moreto be an outstanding medical time to. I was confidentresearch institute. He also believes it that I could do anyto be best placed to lead Australia two of those jobs well.into the next generation of medical However, by tryingresearch. to do all three, I was compromising all ofAlthough currently residing in them.Brisbane, Professor Mattick is a bornand bred Sydney-sider. “There was really no Professor John Mattick AO FAA choice. In 2006 I elected to go Image courtesy of Paul Harris, seesaw photography“I grew up here, mainly in the inner back to research for a while, as I didwest. I lived for a while as a student not want to die wondering,” said of our development and cognitiveat the bohemian (Woolloomooloo) Professor Mattick. complexity. It also opens manyend of Victoria Street,” (the same avenues for entirely novel It is this research that hasstreet on which Garvan is located). therapeutic approaches. transformed the way scientists nowIn 1988, Professor Mattick was lured think about the human genome, our Of Garvan’s future, Professorto Queensland by an invitation evolution and our brain. Previously, Mattick says, “There is presentlyfrom the University of Queensland it was believed that only a few per a great opportunity to do ‘nextto apply for a Foundation cent of the genome (the protein- generation’ science and medicine,Professorship in Molecular Biology, coding part and nearby regulatory using the amazing advances inand at the same time, to start a new sequences) was actually useful. The technology that have occurred overcentre in molecular biology. rest was labeled “Junk DNA”. By the past decade, especially in DNA challenging this long-held belief, sequencing, and thereby to connect“By the end of the first five years, Professor Mattick was able to our capabilities directly with thewe were self-sufficient. A few years show that this “Junk DNA” actually health and medical concerns of thelater, we had more research income specifies a massive hidden layer of community. I think this will be thethan another local university. It was regulation that directs the processes true flowering of medical researchdue to the vision we set out and of our development from a single institutes, and I want Garvan,judicious appointments of gifted cell to a finely sculpted organism of through its close collaborationpeople. This is a great formula, 100 trillion cells that can walk and with St Vincent’s Hospital, andand the Centre matured into the talk. This insight has made scientists the opportunities presented by theInstitute for Molecular Bioscience re-think biology and consider a joint Kinghorn Cancer Centre, to(IMB), now recognised as one of previously unknown level of the lead the way.”Australia’s best. genetic programming
  • 4. breakthroughCures can take more Featurethan a lifetime Gabriele (Gay) Marx is described by her godson, Mark Hedges and wife Robyn as, “a formidable Type lady with a heart of gold.” Almost a million “She was always a forthright, business-like woman, but if you Australians are currently took the time to get to know her, it was well worth it. I feel a great living with diabetes, and deal of warmth and respect for Gay,” said Mark. a further 275 develop A very successful diabetes every day. businesswoman, Gay ran a bookkeeping service in Sydney Significant Garvan Research Discoveries in for almost 30 years. Diabetes and Obesity Mark’s mother shared a life-long • Low dose insulin infusion can help people The late Gay Marx friendship with Gay, who was in diabetic comas saving thousands ofconsidered part of the Hedges family, and they were part of hers. lives since 1973.Gay never married, and with no children, asked Mark and Robyn tobe the executors of her estate. This included managing a generous • Abdominal fat is a key risk factor forbequest to the Garvan. insulin resistance and Type 2 diabetes.Gay was reasonably healthy, but over the years her health • Fish oil in the diet increases insulindeteriorated. “I think that’s where the interest in medical research sensitivity and reduces the risk of diabetes.came from. She supported a range of medical charities duringher life (including Garvan), and she left the bulk of her estate to • Modest weight loss reverses damagingmedical research,” said Robyn. changes seen in the immune cells of obese people. • Development of a simple ‘field friendly’ tool to identify individuals at high risk of TIP: When shares have been left to a charity, consider transferring them directly to the charity. Selling shares within a estate, Type 2 diabetes in low income countries. • PYY, a hormone released by the gut, then forwarding the funds can result in capital gains and transaction tax can be used to treat obesity and Type 2 implications that can have a significant impact on the final value of the diabetes. bequest as charities are exempt from capital gains and transaction tax. • Isolation of small molecules from the vegetable bitter melon that improve insulin sensitivity.Including a charity • Discovery of new actions of insulin using proteomics including regulation of mRNAin your will processing and autophagy. • Insulin resistance in human muscle is highly selective for carbohydrateSadly, only 7.5 per cent of Australians leave a bequest to charities in metabolism providing new insights intotheir will. If this figure doubled, it would result in an additional $440 the mechanism of the disease and how itmillion each year to assist the work of not-for-profit organisations. should be treated more effectively.Garvan has joined with more than 100 other organisations in theInclude a Charity initiative, promoting philanthropic bequests. • Too much fat in the diet kills insulinLeaving a bequest to Garvan is a wonderful way to make producing pancreatic beta cells and thea significant and enduring contribution to the future of discovery of new genes that might reversemedical research. this effect.For more information about leaving a bequest to Garvan, • Contrary to dogma, strategies thatplease contact Carol O’Carroll on 02 9295 8117, or email increase fat burning do not necessarilyc.ocarroll@garvan.org.au lead to reduced whole body fat mass.
  • 5. December 2011 | Issue 18 5story:2 diabetes body weight. This is because storing extra fat traditionally provided protection against times of food shortage. Garvan researchers are using a large arsenal to tackle this problem. The body’s response to food is complex. If we overeat, the extra calories are rapidly absorbed and stored by our adipose tissue. Indeed our body fat stores can increase considerably in just a few days of overeating. Normally our fat cells send signals to the brain to cut down on eating, but for some reason this wiring system can go wrong in certain people. One of the consequences of overeating is insulin resistance, a phenomenon where insulin is secreted from the pancreas, but it doesn’t work efficientlyMuscle Tissue. Muscle responds to insulin and takes up glucose from the due to a block in the insulin regulated machinery in muscle,blood. It is one of the critical tissues for controlling blood glucose levels. fat and liver cells as well as in the brain. Garvan researchers are at the forefront of mapping pathways that underpinWhat is Type 2 diabetes and how did I get it? insulin resistance.After eating, we need insulin, a hormone made in the Not all insulin resistant people develop diabetes, but somepancreas, to channel sugar from our blood into our do, and this may represent the interplay between genescells. In Type 1 diabetes, a less common form of the and the environment. Hence, it is important to identifydisease, the part of the pancreas that manufactures those genes so that we can determine which individualsinsulin is accidentally destroyed by the immune are most at risk. Garvan scientists are gearing up for ansystem leading to a complete lack of insulin. In Type ambitious venture to identify these genes in Australians with2 diabetes, which accounts for around 90% of all Type 2 diabetes.diabetes, the pancreas still produces insulin, butnot enough to properly regulate sugar metabolism Unlike Type 1 diabetes, Type 2 diabetes is reversible. Thisbecause our cells do not respond properly to insulin. gives us hope that we can do something to help people,Therefore, in Type 2 diabetes, there are defects in our no matter how far along they are in the course of thetissues and in the pancreas leading to elevated blood disease. One way is to reverse the insulin resistance, and thesugar levels. other is to make the pancreas more efficient at producing insulin. Garvan scientists have discovered a novel gene thatType 2 diabetes is often, but not always associated regulates pancreas development and this gives us newwith obesity and this is why obesity is a major insight into the malleability of this process.risk factor for diabetes. Obesity is a result of anoverconsumption of food and/or not enough exercise, Type 2 diabetes and obesity are NOT due to a lifetime ofwhich can explain why Type 2 diabetes has been slothfulness and gluttony. This is one of the major mythsreferred to as the ‘scourge of modern life’. about metabolic diseases like diabetes. We are controlledObesity and Type 2 diabetes are heritable by our genes and these may work differently, dependingdisorders. Studies in identical twins reared apart upon the environment they are exposed to. This is why somefrom birth show that genes, rather than environment, people can avoid the temptation to overeat, while othersis the major determinant of body mass. Does this cannot. It is an unavoidable consequence of modernisation.mean that a human’s genes have changed in thelast 50 years? Not necessarily, but the environment You don’t die of diabetes! True - what you do die of is thehas changed and it has impacted most on those heart disease, the kidney failure, a stroke, or possibly cancerwho have a genetic predisposition to eating more that you acquire as a consequence of your diabetes. Worstfood and/or doing less exercise. What we all have of all, as the excesses of the western world spread acrossin common is the drive to eat and to reproduce, the globe, diabetes, and all of these other problems, areand this is “hard-wired”. For some reason, many of rapidly following.us now eat too much, thus defying physiologicalprocesses that would normally inform the brain that Garvan scientists are using sophisticated technologieswe have eaten enough. to unravel the complex relationship between genes, food and health. We believe the solution to this problem willDieting is extremely difficult and usually fails be neither simple nor immediately forthcoming, but it isbecause our bodies are programmed to defend achievable and we must urgently find it. It will require time,an increased body weight rather than a decreased resources and commitment to embrace this challenge.
  • 6. breakthroughStaff Profile:Dr Ann McCormack I am currently leading a project have found that the MGMT gene investigating the use of pathological probably plays an important role in markers as a predictive tool to help the development of an aggressive us determine which tumours may pituitary tumour. become an aggressive cancer. I have In other work, we have identified a also set up a project to investigate the new inherited mutation in the AIP Australian prevalence of mutations in gene in a young patient suffering from a newly recognised gene implicated gigantism, a condition resulting from in familial pituitary tumour syndromes. a growth hormone secreting pituitary The future of pituitary tumour tumour. We are now about to embark research will be greatly facilitated on screening other members of this by the development of a National patient’s family for the same mutation. Pituitary Tumour Registry and The hope is that identification of the biobanking, which I am actively mutation in other family members may involved in establishing. The other lead to earlier detection and treatmentWhat is the current focus of exciting emerging area of research of a pituitary tumour.your work? I am pursuing aims to gain a better What is the biggest challenge inMy primary research interest relates understanding of the role that your area of research?to the pituitary gland. The pituitary hormones derived from the pituitary, as well as hormones that communicate Like all other researchers, findinggland is located in the brain and has funding for research is a battle,been affectionately coined “the master with the pituitary, have in a number of other diseases such as cancer, particularly in the early stagesgland”. It regulates other important of establishing a research career.glands in the body such as the thyroid, osteoporosis, obesity and diabetes. It is hoped that this will identify treatments However, for my work, an addedadrenal and reproductive organs. difficulty is the lack of awarenessOne area of my research focuses on that can modulate the hormonal environment and thus offer improved of the pituitary gland. With thepituitary tumours. Pituitary tumours right support, we can increase theare common and cause headaches, outcomes for the millions of patients with these diseases. understanding of this vital gland andvisual loss and/or hormonal the hormones it produces. I believedysfunction. The hormone dysfunction What are some of the recent benefits for patients with a range ofhas far reaching effects with patients findings of your work? conditions will transpire as a result.having increased rates of diabetes, In my doctorate I studied a geneosteoporosis, and infertility, to mention What do you enjoy doing away from (MGMT) whose expression predictsa few. Patients with pituitary tumours the lab? response to a chemotherapeutichave an increased mortality compared agent used to treat aggressive I am a mother of two young childrenwith the general population and have pituitary tumours. We determined and I thoroughly enjoy the time I havea significant reduction in quality of life. that the best way of assessing this with them. This doesn’t leave muchOne in every 1000 individuals has a gene was by using the technique of spare time, although I always lookclinically significant pituitary tumour. immunohistochemistry, a common tool for excuses to travel. I am a keenHowever, data from autopsy and used by pathologists. This biomarker skier and love to spend time dreamingimaging studies have found that, in has now reached clinical practice about which mountain to explore onfact, 20% of the population harbour in the assessment of an aggressive the next ski holiday.a pituitary tumour. pituitary tumour. In addition, weCongratulations to the many individuals and teams whohave recently laced up their running shoes, and hit the road in supportof Garvan Institute of Medical Research. Special mention should be givento Jane Hemstritch who, along with her team, ‘Team Phil’, participated inthe Run Melbourne event. So far, Jane has raised more than $75,000 forthe Australian Pancreatic Cancer Genome Initiative (APGI). This initiativeis part of the International Cancer Genome Consortium, and APGI isco-led by Professor Andrew Biankin from the Garvan, and Professor SeanGrimmond from the Institute of Molecular Bioscience in Brisbane. TeamPhil is named in memory of Jane’s late husband, Phil Hemstritch who losthis battle with pancreatic cancer in 2010. Congratulations to Jane andTeam Phil for their passion and commitment. Jane Hemstritch (centre) and Team Phil’
  • 7. December 2011 | Issue 18 7 In memory of aAsk Garvan remarkable manQ: How did Garvan get itsname? Joshua Berger, Director of Fivex CommercialA: In 1957, when the Sisters Property, describes his lateof Charity were looking to father Marko (Mordechai)raise funds for a research Berger as, “A down-to-institution, a lady by earth gentleman.the name of Helen Mills A very remarkable,offered to donate a sum uncomplicated man.”of £100,000 in the name To honour the memoryof her late father, James of Marko, and hisPatrick Garvan. James Patrick Garvan extraordinary life,James was born in Ireland in 1843, and came Joshua makes an annualto Sydney with his family in 1847. A successful contribution to Garvan’sbusinessman, he established the Australian NeurodegenerativeTerminating Building Society, and the North Disorders research group, Marko Berger headed by Dr Bryce Vissel.Shore Steam Ferry Co Ltd. He also founded theCity Mutual Fire Insurance Co. Ltd and the City Marko was born in Czechoslovakia in 1920, the youngestMutual Life Assurance Society Ltd. Later, he of seven children. When World War II began, Markofounded the Citizens’ Life Assurance Co. Ltd, joined the Czech Jewish Army. He was injured andwhich later became MLC (a major supporter managed to hide from the Germans for a year, until heof the work of the Garvan). was eventually captured. He spent the rest of the war in various concentration camps, and emerged weighingJames was a leading parliamentarian, and also a 35kg, and with no hair. While Marko, his parents, and twokeen sportsman. At one stage, he held the record of his sisters survived the war, tragically three brothers andfor throwing a cricket ball the furthest (121 yards). another sister did not.On his death in 1896, Sir Edmund Barton Following the war, Marko not only survived – he flourished.acknowledged his, “entirety of life, adorned with In 1948, he married Lily, the love of his life. In 1955, withconsistent principle, filled up in the discharge their son Joshua, the family moved to Australia. Arriving inof virtuous duty, with nothing to conceal, no Australia with little in his pocket, Marko set about sellingfriendship broken, no confidence betrayed, no timid shoes at Paddy’s Markets. It was not long before he hadsurrender to popular clamour, no eager reaches for established a successful business.popular favour.” Marko lived life to the full, enjoying every moment. Of his contribution to Garvan, Joshua says, “My dadTopping Out Ceremonies was successful in the way he lived his life in the field of business and in general. He always wanted to be anFirst glimpse inside inventor, yet that is one area of his life that he did not actually succeed in. I think he’d have a chuckle to think heThe Kinghorn Cancer Centre was participating in the process of invention by proxy!Events held in late August and early September gave “He set the standard and tone of our family, and he is terribly missed. However, his spirit lives on through hisKinghorn Cancer Centre visionaries, as well as St family, and his memory lives on through this contributionVincent’s and Garvan cancer staff the opportunity to to the work of the Garvan.”don a hard hat and get their first glimpse inside TheKinghorn Cancer Centre. Guests received an insightinto the layout of the ground floor, as well as a veryspecial trip to the “top” of the site. Announcing Garvan Australian Proms Stars of Australian opera, musical theatre and jazz will join forces at Sydney Town Hall on Saturday 28th April 2012 for the inaugural Garvan Australian Proms. Featuring the Sydney International Orchestra and the Garvan Proms Choir, this event will be a celebration of the Australian spirit and Australian talent. Importantly, it will also help to raise vital funds for cancer research at the new Kinghorn Cancer Centre. More details will be released soon, so mark the date in your diary and keep an eye out for more information, including how to buy your tickets, at www.giving.garvan.org.au Left to right: Professor John Shine AO FAA, Mr John Kinghorn, Mrs Jill Kinghorn and Mr William (Bill) Ferris AC Don’t forget to bring your Australian flag for the rousing finale!
  • 8. Clinical Studies In Memoriam July 2011 – October 2011. Donations have been made in memory of:Study on Fat MetabolismWe are looking for healthy volunteers: men and postmenopausal women, aged 50-70 years Michael Abicare Margaret Dunn Anthony Morganfor research into hormones and body fat. This study involves visits over a 14 week period to Gordon Adamson Patricia Fleming Michael Morlingthe Garvan to study the effects of three commonly used medications, oestrogen (women Daniel Anisimoff Mim Gadd Ralph Mooreonly), letrozole and tamoxifen on the burning of fat in the body. We will investigate how fat Doug Bailey Carmel A Galvin Leonhard Neumeyeris utilised at whole body and liver level. Betty Bale Max Gibbs Joyce NichollsFor further information please contact: Moses Bainy Ted Gooch Adrian NotleyDr Vita Birzniece (02) 9295 8483, v.birzniece@garvan.org.au or John R Barbour Anna Grunstein Frances PizzolatoVanessa Travers (02) 9295 8232, v.travers@garvan.org.au(St Vincent’s Human Research Ethics Ref No 09/090). Bob Bauza Roy Hall Meril Pocklington Lynda Beattie Joan Harrison Eileen ProsserDiabetes Study John Bell Valerie Heath Loulouka RaftopoulosAre you interested in improving the control of your diabetes? We are studying the effect Keith Bell Nola Hibberd Robert J Riceof the amino acid glutamine on glucose control in Type 2 diabetes. We are looking forpeople with Type 2 diabetes for less than five years, males and females ages 40-75 years, Paul Bell Thomas Harvie Hill Grace Rumsbyonly on Metformin (ie not taking insulin or other diabetes medications). Deiter Blaufelder Marguerite Hillman Joyce Patricia Nigel Blyth Reta Millicent Hoare SeibrightFor more information contact: Peter Boersma Stuart John Hoy Shirley SimsRenee Richens on (02) 9295 8215, email r.richens@garvan.org.au Wilhelmina Boon Ralph Hunt Gordon Smith(St Vincent’s Human Research Ethics Ref H07/059 version 1). Peter Bowyer Rae Jeffreson Richard SmithMetabolism – Genetics of Obesity Study Valerie Smith Betty Bresnahan Arthur JenkinsDo you think you could be overweight? Volunteers are needed to screen for a gene that Andre Bretagne Steve Jobs Joan Streatfeildlinks to obesity at the Garvan Institute. It involves only one visit during which measurements Sue Buncombe Patrick Kelleher Christine Stevensand a blood test will be taken. If you are suitable, you may enter the second part of the (nee Bell)study to receive a full metabolic assessment. Yvonne Burrows Tony Keon Rhea TahnFor further enquiries, please contact: Gordon Elliott Camp Zelma Lawrence Adrian J TaylorDr Daniel Chen (02) 9295 8557 or d.chen@garvan.org.au or Len Capellari Pat Lawson Klara TorheidenVanessa Travers (02) 9295 8232 or v.travers@garvan.org.au Mary Christie Donald Magill(St Vincent’s Human Research Ethics Ref HREC/10/SVH/133). David Victor Torr Antonio Colosi Michael Maher Jenny Wareham Eleni Coluzzi Shirley Maher Judith Ann WatersComing Up Jim Cunningham Joan De Boos Lawrence B McMurray Joyce Irene Mealing Rosemary WheenGarvan’s 2012 free public seminar series has been announced. Join us to hear about Harry Widdup Malcolm John Denner Katherine S Mignotthe latest developments in diagnosis, treatment and prevention of some of the most Margaret Peggy Ryan Densby Norman L Millers Wilsonwidespread diseases affecting our community today. Full details for each seminar will Sue Dowlan Jim Miltonbe available on Garvan’s website shortly. John Victor Duggan Matina Minos29 March – Immunology. 10am – 12 noon.24 May – Ovarian Cancer. 10am – 12 noon.9 August – Osteoporosis and Bone. 10am – 12 noon.20 September – Alzheimer’s disease and other neurodegenerative disorders. 10am – 12 noon. BREAKING NEWS! For the first14 November – Type 2 diabetes and obesity. 10am – 12 noon. time, Garvan’s 2012 seminars will also be available asRegistrations are now open for all seminars. Please note that registration is essential. live webcasts via www.giving.garvan.org.au/seminarsTo register, visit www.giving.garvan.org.au/seminars or phone (02) 9295 8110. BE PART Please use this coupon if you would like to make a donation to Garvan’s breakthrough medical research, or if you would like DONATE NOW OF PROGRESS further information. We would love to hear from you. CLICK HERE My Contact Details My Gift Details Title First Name Yes! I want to help Garvan make progress with a gift of Surname $50 $100 $250 $500 $1000 Gift of choice $ Address My cheque/money order made payable to Garvan Research Foundation is enclosed Suburb State Postcode OR Please deduct the above amount once monthly annually Daytime Phone from my Visa MasterCard Amex Diners Email Card Number Garvan Supporter Number (if known) Expiry Date / 2011BT03 Please Send Me Further Information About: Cardholder’s Name Giving to Garvan in my will (strictly confidential) Signature Volunteering with Garvan Donations of $2 and above are tax deductible. Giving regularly to Garvan through my bank account Please complete this coupon and mail it to: Please Change My Communications: Garvan Research Foundation Reply Paid 68593, Darlinghurst NSW 2010 I no longer wish to receive this breakthrough newsletter Call: 1300 73 66 77 (9am to 5pm) I only wish to receive breakthrough by email Fax: (02) 9295 8507 I only wish to receive appeal mailings in May/June (you can use this coupon) I do not wish to receive any appeal mailings Online: www.giving.garvan.org.au

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