Prenatal Exposure To Endocrine Disruptors And Its Impact On Adult Onset Disorders


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GRF 2nd One Health Summit 2013: Presentation by P. S. MOHANKUMAR, Michigan State University

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  • Welcome everyone to the symposium on Endocrine disruptors and their impact on Adult onset disorders. We would like to thank Dr. Walter Amman and the organizing team for selecting our proposal for presentation and Drs. Ian Gray and Reza Nassiri, Michigan State University, for their support
  • Dr. Lou Anna Simon, President of Michigan State University has recognized the value of developing the concept of “One health” and through her “boldness by design” initiative promotes the integration of various disciplines such as Environmental health, Human health, Animal health, food and water safety and communication to address global Health issues. In this symposium, we will be focusing on three main areas, Environmental safety, Human and animal health.
  • Plastics have become an integral part of our lives. They are cheap, moldable, durable and have a wide range of uses from medical equipment to toys to shopping bags. They cannot decompose easily and therefore persist in the environment. Several chemicals are used for the synthesis of plastics and many of them are endocrine disruptors. Epidemiological studies on the use of plastics and the prevalence of non-communicable diseases indicate that
  • Exposure to these EDCs is a serious One health issue. In developing nations, where disposal of plastics is not well regulated, we have cows and sheep grazing on these plastics. This gives them indigestion, but since they are broken down to a certain extent in the rumen, there are greater chances for EDCs to be liberated and enter the circulation contaminating meat and milk. Although humans are exposed to BPA and DEHP through several routes, consumption of contaminated meat and milk is another potential mode of exposure. Therefore, it is important to understand the mechanisms by which EDC exposure can cause non-communicable diseases in humans and also pets. The talks in this session will explore the effects of BPA on reproductive and cardiovascular functions, the effects of a mixture of BPA and DEHP on body functions and investigate the use of stem cells to screen for the presence of EDCs. Our first speaker, Dr. VasanthaPadmanabhan from the University of Michigan could not be here, but Dr. P.S. MohanKumar will be presenting her talk instead.
  • Prenatal Exposure To Endocrine Disruptors And Its Impact On Adult Onset Disorders

    1. 1. Endocrine Disruptors and their impact on Adult onset disorders P. S. MohanKumar1, Vasantha Padmanabhan2, Kyung-Sun Kang3, Reza Nassiri1 & Sheba MohanKumar1 1Michigan State University and 2University of Michigan, USA & 3Seoul National University
    2. 2. Institute of International Health
    3. 3. Use of EDCs • Benefits of using EDCs – Plastics • Cheap, Moldable, Durable, Wide range of uses – Fertilizers – Many other uses: Water repellants, Fire retardants • Drawbacks: -Do not decompose easily -Contaminate the environment -Plasticizers are endocrine disrupting chemicals (EDCs)
    4. 4. EDCs – a One health problem EDCs: Plasticizers, Fertilizers, Insecticides, Water repellants, Fire retardants, etc. Animal Health Human Health
    5. 5. Investigating the health effects of EDCs – a model for ‘One health’ • Animals and humans are exposed to EDCs • Serves as an excellent model to study the effects of environmental contaminants on human and animal health. • Addresses the social, environmental, business as well as political aspects of addressing environmental contaminants.