Integrative Therapies in the Prevention and Treatment of Type 2 Diabetes


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GRF 2nd One Health Summit 2013: Presentation by ROSICK, Dr. Edward Rudolph, Michigan State University College of Osteopathic Medicine

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Integrative Therapies in the Prevention and Treatment of Type 2 Diabetes

  1. 1. Edward R. Rosick, DO, MPH, DABIHM Associate Professor, Chair, Medical Director Family Medicine Department Michigan State University College of Osteopathic Medicine East Lansing, MI USA
  2. 2. • • Type 2 diabetes is a world-wide health issue-- affects 250 million globally and is projected by the WHO to affect at least 380 million by 2025. Significant cause of morbidity and mortality in 3rd world/emerging countries. In Mexico, type 2 diabetes is the primary cause of non-obstetric hospital admissions and the third leading cause of mortality. (Guzman, Rev Panam Salud Pub 2010) • In other areas of Central America such as Guatemala, type 2 diabetes is a significant emerging public health issue.(Chary et al., Health Serv Research 2012)
  3. 3.  Worldwide Obesity Epidemic—paradox of poor nutrition and gaining weight  Shift from an Indigenous to a ‘Western’, or Standard American Diet  Urbanization of Workforce
  4. 4. Example of white rice consumption—tripled in Latin America over past 60 years—a high glycemic index food that has replaced many endogenous crops such as beans.  Multiple studies show that a diet high in beans can significantly improve glycemic index and decrease risk of type 2 diabetes(Peterson et al., Nutr Rev 2010; Jenkins et  al., Arch Inter Med 2012; Slyper, Jour Ped Endo Metab 2013)
  5. 5. Multiple studies continue to point to the strong correlation between the lack of exercise and type 2 diabetes  Recent Meta-analysis examined 7 randomized controlled trials of lifestyle interventions to prevent diabetes. Results showed that lack of physical activity is directly correlated with an increased risk of developing type 2 diabetes. (Yoon et al., Metabolism,  2013).
  6. 6.    Bitter Melon (Momordica charantia) Widely cultivated in Asia, Africa, and South America Multiple compounds are thought to have antidiabetic properties including steroids and an insulinlike polypeptide (polypeptide P)
  7. 7. Case control study of 100 men and women with type 2 diabetes (Fuangchan et al., Jour Ethnopharm 2011)  Results showed an 18% mean reduction in both fasting and postprandial glucose levels among subjects  Dosage levels range from 600 mg to 2 grams daily 
  8. 8. Nopal (Opuntia streptacantha)—found throughout the Americas.  2003 article in Diabetes Care by Argaez-Lopez et al. on use of CAM in type 2 diabetics in Mexico.  73% of respondents indicated using Nopal to help treat their type 2 diabetes 
  9. 9. High fiber and pectin content may decrease intestinal glucose uptake  Animal models have shown both a decrease in postprandial glucose levels and HA1C (Andrade-Cetto  et al., Jour Ethnopharm 2011)  Limited human studies show acute hypoglycemic effects in patients with type 2 diabetes (Feugang et al., Fron Biosci 2006)
  10. 10.    Smilax officinalis—perennial trailing vine with prickly stems native to Central America. Contains steroidal saponins and phytosterols Potential anti-oxidant and hyperglycemic activity (Andrade-Cetto et al., Jour Ethnopharm 2005; Ranilla et al., Bioresource Tech 2010)
  11. 11. Maximize cellular energy production  Improve blood sugar utilization  Lower cellular inflammation  Other studies have shown at low levels of magnesium intake are correlated with higher levels of developing type 2 diabetes (Hata et al., Diabetes  Med 2013)  Dose:400-800 mg/daily
  12. 12. Chromium has been shown to cause improvements in: --insulin sensitivity --HbA1C levels (Sharma S et al., Jour Trace Elem Med Biol 2011) Doses for supplementation range from 200-400 mcg (micrograms) daily 
  13. 13. Type 2 diabetes is a transcending global health problem that is pays no respect to national borders or cultures.  Through integrative & multidisciplinary strategies and solutions, type 2 diabetes can be both prevented and treated in economically and culturally viable ways. 