Integrative Therapies in the Prevention and Treatment of Type 2 Diabetes

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GRF 2nd One Health Summit 2013: Presentation by ROSICK, Dr. Edward Rudolph, Michigan State University College of Osteopathic Medicine

GRF 2nd One Health Summit 2013: Presentation by ROSICK, Dr. Edward Rudolph, Michigan State University College of Osteopathic Medicine

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  • 1. Edward R. Rosick, DO, MPH, DABIHM Associate Professor, Chair, Medical Director Family Medicine Department Michigan State University College of Osteopathic Medicine East Lansing, MI USA rosick@msu.edu
  • 2. • • Type 2 diabetes is a world-wide health issue-- affects 250 million globally and is projected by the WHO to affect at least 380 million by 2025. Significant cause of morbidity and mortality in 3rd world/emerging countries. In Mexico, type 2 diabetes is the primary cause of non-obstetric hospital admissions and the third leading cause of mortality. (Guzman, Rev Panam Salud Pub 2010) • In other areas of Central America such as Guatemala, type 2 diabetes is a significant emerging public health issue.(Chary et al., Health Serv Research 2012)
  • 3.  Worldwide Obesity Epidemic—paradox of poor nutrition and gaining weight  Shift from an Indigenous to a ‘Western’, or Standard American Diet  Urbanization of Workforce
  • 4. Example of white rice consumption—tripled in Latin America over past 60 years—a high glycemic index food that has replaced many endogenous crops such as beans.  Multiple studies show that a diet high in beans can significantly improve glycemic index and decrease risk of type 2 diabetes(Peterson et al., Nutr Rev 2010; Jenkins et  al., Arch Inter Med 2012; Slyper, Jour Ped Endo Metab 2013)
  • 5. Multiple studies continue to point to the strong correlation between the lack of exercise and type 2 diabetes  Recent Meta-analysis examined 7 randomized controlled trials of lifestyle interventions to prevent diabetes. Results showed that lack of physical activity is directly correlated with an increased risk of developing type 2 diabetes. (Yoon et al., Metabolism,  2013).
  • 6.    Bitter Melon (Momordica charantia) Widely cultivated in Asia, Africa, and South America Multiple compounds are thought to have antidiabetic properties including steroids and an insulinlike polypeptide (polypeptide P)
  • 7. Case control study of 100 men and women with type 2 diabetes (Fuangchan et al., Jour Ethnopharm 2011)  Results showed an 18% mean reduction in both fasting and postprandial glucose levels among subjects  Dosage levels range from 600 mg to 2 grams daily 
  • 8. Nopal (Opuntia streptacantha)—found throughout the Americas.  2003 article in Diabetes Care by Argaez-Lopez et al. on use of CAM in type 2 diabetics in Mexico.  73% of respondents indicated using Nopal to help treat their type 2 diabetes 
  • 9. High fiber and pectin content may decrease intestinal glucose uptake  Animal models have shown both a decrease in postprandial glucose levels and HA1C (Andrade-Cetto  et al., Jour Ethnopharm 2011)  Limited human studies show acute hypoglycemic effects in patients with type 2 diabetes (Feugang et al., Fron Biosci 2006)
  • 10.    Smilax officinalis—perennial trailing vine with prickly stems native to Central America. Contains steroidal saponins and phytosterols Potential anti-oxidant and hyperglycemic activity (Andrade-Cetto et al., Jour Ethnopharm 2005; Ranilla et al., Bioresource Tech 2010)
  • 11. Maximize cellular energy production  Improve blood sugar utilization  Lower cellular inflammation  Other studies have shown at low levels of magnesium intake are correlated with higher levels of developing type 2 diabetes (Hata et al., Diabetes  Med 2013)  Dose:400-800 mg/daily
  • 12. Chromium has been shown to cause improvements in: --insulin sensitivity --HbA1C levels (Sharma S et al., Jour Trace Elem Med Biol 2011) Doses for supplementation range from 200-400 mcg (micrograms) daily 
  • 13. Type 2 diabetes is a transcending global health problem that is pays no respect to national borders or cultures.  Through integrative & multidisciplinary strategies and solutions, type 2 diabetes can be both prevented and treated in economically and culturally viable ways. 