Global Health Crises Caused By The Collision Of Biological And Cultural Evolution: Pre-Natal Influences On Acute And Chronic Diseases Later In Life

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GRF 2nd One Health Summit 2013: Presentation by TROSKO, Dr. James Edward, Michigan State University

GRF 2nd One Health Summit 2013: Presentation by TROSKO, Dr. James Edward, Michigan State University

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  • Fig. 3. The potential for exposure to engineered nanomaterials exists during both in utero and postpartum development. Differences in the types and developmental
    status of biological barriers and the types of exposure routes are depicted here. Some sources of exposure are likely specific to developmental stages as
    well, for instance, children might mouth their hands or other body parts, which could lead to oral exposure to sunscreen but this would be unlikely to be a source
    of oral exposure for mothers. Similarly, oral or dermal contact with toys is more likely for young children than mothers. C.M. Powers, 134: 225, 2013

Transcript

  • 1.   “GLOBAL HEALTH CRISES CAUSED BY THE COLLISION OF BIOLOGICAL AND CULTURAL EVOLUTION: PRE-NATAL INFLUENCES ON ACUTE AND CHRONIC DISEASES LATER IN LIFE” Prof. James E. Trosko Department of Pediatrics/Human Development College of Human Medicine & Prof. Reza Nassiri Institute International Health College of Osteopathic Medicine Michigan State University East Lansing, Michigan 48824 E-mail: james.trosko@ht.msu.edu
  • 2. THE GLOBAL HEALTH PROBLEM • Currently there are 7 Billion people on Earth. By the end of this Century, Earth will have 3 billion more babies. • Earth’s physical environment (water, air, Global Warming) is being Irreversibly altered. • Earth’s Bio-ecosystem, as it relates to human food supply, is stressed (Crop failures,new microbial invasions,etc.). • Human biological adaptive genome, acquired slowly over millions of years by biological evolution, is becoming stressed by the laser-speed changes in our cultural evolution, by the food/diets that are changing. This includes changes in the human gut microbiome. • Currently, the limited health care resources, devoted towards the Global Health Crisis, is via “crisis medicine” [dealing with the Metabolic Diseases, e.g., diabetes, cardiovascular diseases, cancer, dementia, which are, in large part, caused by bad diets/nutrition] are insufficient to meet the needs of these adult chronic diseases. One Planet-One Health
  • 3. EARLY HUMAN DIET MODERN WESTERN DIET 1. “Feast or Famine” style of eating 1. Caloric Unrestricted. 2. Eat within walking distance. 2. Foods are processed 3. Eat only during the day 3. Foods are found year-round 4. Seasonally-available foods 4. Eat 24 hours a day. 5. Grains, nuts, fruits, waterassociated animals ( omega-3fatty acid-rich foods). 5. Red meat/ grilled or fried 6. Ate these foods without grilling. 7. Low caloric intake 6. Use of dietary supplements
  • 4. Potential Partial Solution to these Problems Since many of these acute and chronic human disease are influenced during normal human development during in uterine exposures, prevention of harmful factors during the pregnancy of these 3 Billion new babies would seem to be both moral and scientifically achievable goals. Education of new parents of healthy diets during pregnancy and neonatal development should be a moral and political global challenge, recognizing enormous cultural , economic , political and scientific/technological barriers. A shift in how the distribution of limited health care resources are to be spent on “crisis” versus “preventive” Medicine will take courage. This goal is based on the scientific basis of the Barker Hypothesis.
  • 5. THE BARKER HYPOTHESIS THE BARKER HYPOTHESIS Prenatal exposures can influence the risks to diseases later in life
  • 6. PREVENTIVE MEDICINE STARTS PREVENTIVE MEDICINE STARTS HERE HERE
  • 7. BARKER HYPOTHESIS Few Examples • Maternal obesity increases risks to offspring obesity, metabolic syndrome, hypertension, kidney size, lung function, polycystic ovaries and cancers. • • David Parker: Fetal Experience Affects Chronic Diseases later in Life Diethylstilbestrol (DES)- induction of human vaginal cancers Bis-Phenol A induction coat color & obesity in rats • Soy product reduction of breasts, breast cancer and induction of osteoporesis. Facts of the study of the atomic bomb survivors. • C. Lau, eta., Fetal Programming of Adult Diseases .Obstetrics & Gynecology 117:
  • 8. BARKER HYPOTHESIS: IN UTERO EXPOSURES & RISKS TO DISEASES LATER IN LIFE C.M. Powers, Tox Sci 134: 225-242, 2013
  • 9. BREAST CANCER NEWS BREAST CANCER NEWS
  • 10. • Genistein & Bowman-Birk Inhibitor as Bioactive Components of Soy Products Hsieh CY,& Chang, C.C. “Stem Cell Differentiation and Reduction as a Potential Mechanism for Chemoprevention of Breast Cancer. Clin Pharm J. 51: 15-30, 1999. [ and inducer of osteoporoses]
  • 11. Induction of Differentiation of Human Adult Breast Stem Cells Panel A. Solvent control; Panel B Cholera Toxin-Positive Control; Panel C. Genistein (10-7 M); and Panel D. Vitamin D3. 12 days after treatment.
  • 12. THE TROSKO HYPOTHESIS THE TROSKO HYPOTHESIS Alteration of organ-specific stem cells by environmental pollutants, stress, nutrition, and drugs can modify the risk to stem cellbased diseases later in life
  • 13. GLOBAL DIET & DISEASE GLOBAL DIET & DISEASE Global Incidence of Colon Cancer
  • 14. Size of spheres BREAST TUMOR PROMOTERS E2 TCDD BPA Non-M M1 M10 NC : Negative control E2 : 10nM estrogen TCDD : 100nM BPA : 10uM M1 : Metformin 1mM M10 : Metformin 10mM USE OF HUMAN ADULT BREAST CANCER STEM CELLS in 3-D CULTURES to SCREEN FOR TUMOR PROMOTERS & CHEMOPREVENTIVE AGENTS BREAST CHEMOPREVENTIVE AGENTS Control
  • 15. “When diet is wrong, medicine is of no use. When diet is correct, medicine is of no need” Ancient Ayurvedic Proverb
  • 16. THANK YOU THANK YOU