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  • 1. Probiotics
  • 2. There are up to 400 different bacterial species in the colon and the vast majority (99.9%) are strict anaerobes .Genus Log10 bacteria per gram feces Non-sporing anaerobes  Bacteriodes spp. 10- 11  Bifidobacterium spp. 10- 11  Eubacterium spp. 9 - 11  Propionibacterium spp. 9 - 11  Veillonella spp. 5 - 8 Sporing anaerobes  Clostridium spp. 5 - 9 Sporing aerobes  Bacillus spp. Microaerophiles  Lactobacillus spp. 7 - 9  Streptococcus spp. 7 - 9  Enterococci 5 - 7 Facultative organisms  Coliforms 7 - 9  other Enterobacteria 5 - 9 http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf
  • 3.  For context – Total Cells  Them ~ 100,000 billion.  You ~ 10,000 billion.
  • 4. Microbiotic therapy Indications for use: Crohns disease, ulcerative colitis, intestinal disturbances, gas and bloating, constipation, diarrhea, dysbiosis, yeast-overgrowth, parasites, irritable bowel syndrome, autoimmune conditions, MS, lupus, AIDS, rheumatoid arthritis, during and post antibiotic use, post chemotherapy, post radiation, food allergies, chronic fatigue syndrome and pharmaceutical drug use.
  • 5. The Big players Lactobacillus acidophilus Lactobacillus acidophilus is found primarily in the small intestine It produces natural antibiotics (lactocidin & acidophilin), thereby, increasing your immune systems resistance against bad bacteria and fungus i.e. Candida albicans, Salmonella, E. coli, and Staphylococcus aureus  It implants itself on the intestinal walls, the lining of the vagina, cervix and urethra  For years it was assumed that Lactobacillus acidophilus was the most beneficial form of the good bacteria. However, recent research has revealed that Lactobacillus rhamnosus is just as important for good bacteria supplementation. Bifidobacterium bifidum  Bifidobacterium bifidum reside mainly in the mucous membrane of the large intestine and vaginal tract  Digests lactose  Produces the most beneficial form of lactic acid and acetic acid  Ferments indigestible fibers which produces more energy  Synthesizes some vitamins and aids mineral absorption (calcium, magnesium and zinc)  Inhibits the growth of Salmonella sp., Listeria, Shigella, E. coli and Clostridium per fringens by crowding out these bad bacteria and eating their nutrients  Fights the bad bacteria in your body by lowering the intestinal pH through production of fatty acids  Absorbs large quantities of ferrous ions, inhibiting the growth of bad bacteria  Aids constipation and diarrhea with lactic acid production Lactobacillus rhamnosus    Lactobacillus rhamnosus is a healthier species of good bacteria and colonizes in your gut mucosa  Relieves hypersensitivity reactions and intestinal inflamation in individuals with exzema and food allergies  Excellent stability over a wide range of temperatures and pH levels  Inhibits the growth of bad bacteria  Enhances the immune systems resistance  Demonstrated antitumor activity  Prevents food allergies caused by a "leaky gut" condition
  • 6. More Players Lactobacillus plantarum  Helps produce lactolin, a natural antibiotic  Synthesizes the amino acid, L-lysine, which is anti-viral Bifidobacterium infantis  Present in the intestines of infants and adults  Present in the vaginal tract Lactobacillus salivarius  Destroys harmful bacteria  Aids in bowel disorders Lactobacillus bulgaricus  Used in fermenting natural yogurt  Produces lactic acid  Provides a great environment for Lactobacilli and Bifidobacterium to grow Lactobacillus casei  Close relative to Lactobacillus acidophilus  Secretes "peptidoglycan" a recognized substance that supports the bodys natural defenses Lactobacillus brevis  Produces lactic acid  Synthesizes Vitamins D & K Streptococcus thermophilus  Breaks down milk products by producing lactase (helps individuals that are lactose intolerant)  Destroys Pseudomonas sp., E. coli, Staphylococcus aureus, Salmonella sp., and Shigella  Produces Methanol acetone, a potent anti-pathogenic agent Undesirable types such as E. coli, Klebsiella, Clostridium and Candida albicans.
  • 7. Prebiotics?
  • 8. Fructo-oligo-saccharides Fructo-Oligo-Saccharides (FOS) is a naturally-occurring water-soluble fiber from fruit and vegetables which feeds the friendly intestinal bacteria. FOS generaly ensure rapid establishment of the Lactobacilli in the upper small intestine and bifido bacteria in the lower small intestine. Some, research suggests that there may be health benefits of supplementing the diet with between 5 and l0g of FOS, It, HMF product, also provides naturally-occurring beta-carotene from the whole freeze-dried apricot. The apricot is used for its soothing effect on the intestinal walls (and great flavor in the powders). Townsend letter article http://www.findarticles.com/p/articles/mi_m0ISW/is_2003_June/ai_10237 2155
  • 9. Inulin Inulin  Inulin is a multi-chain fructooligosaccharide derived from chicory root  It is a chain of fructose (a carbohydrate) that is not digestible by your body, therefore, it can pass through the body into the large intestine where it can feed your good bacteria cells  Some, research has suggested that Inulin (9 chain links) is more effective than FOS (3 to 4 chain links) at feeding your bodys good bacteria. Also, Inulin may be better tolerated by humans and bad bacteria are less likely to feed on it.
  • 10.  Human Micro Flora HMF
  • 11. Genestra Brands Form Seroyal New! Oct 2004, all HMF probiotics contain a substantial increase in potency (double) and no price increase. HMF Replete contains…  Lactobacillus acidophilus  Lactobacillus salivarius  Bifidobacterium bifidum  Bifidobacterium lactis Fructo-oligosaccharides  high concentrations ensure rapid establishment and dominance of probiotic cultures in the GI Indicated during and following antibiotic therapy and chemotherapy. 
  • 12. Genestra Brands HMF Replete new and improved formula! Each sachet (20 g) of HMF Replete supplies: Lactobacillus acidophilus .........75 billion CFU Bifidobacterium Bifidum .......12.5 billion CFU Bifidobacterium lactis ........... 12.5 billion CFU Lactobacillus salivarius ........... 30 billion CFU Fructo-oligosaccharides .................... 10 g May contain up to .................. 170 billion CFU
  • 13. HMF Recommendations Intensive Phase  Intermediate Phase Take 1 packet daily (½ packet twice  Take ½ packet daily after meals mixed daily) after meals, mixed in water or off in water or off the spoon. the spoon for 7-14 days.  Clinical Considerations Clinical Considerations  General illness  During and Post-antibiotic therapy  Stressful life style  Acute intestinal upset  Parasitic infections  Candidiasis  Digestive problems (bloating, gas)  Digestive disturbances (bloating, gas)  Constipation  Parasitic infections  Excessive alcohol consumption  Chronic Fatigue Syndrome  Bowel problems (constipation,  Bowel problems (constipation, diarrhea, IBS) diarrhea, IBS)  Chronic Fatigue Syndrome  Candidiasis
  • 14. Genestra Brands HMF Replete Features: HMF replete is the strongest HMF probiotic prolonged stability allowing for storage up to 3 months at room temperature resistant to stomach acidity and bile acids scientific evidence with clinical data to confirm efficacy laboratory tested to confirm potency and purity exceptional ability to attach to intestinal cells due to human sourced lactobacilli and bifidobacteria
  • 15. Genestra Brands Super Powder is a high-level maintenance probiotic formula. Indicated for individuals who use antibiotics, oral contraceptives, steroids and hormonal replacement therapy, and for extreme fatigue, allergies, yeast overgrowth, stress, hypercholesterolemia and indigestion.  HMF Super Powder is highly recommended for ongoing maintenance in individuals who are immuno-compromised. Ideal for children and adults who dislike or have difficulty swallowing capsules.  * Powder is ideal for vegans
  • 16. Genestra Brands Each 1/4 teaspoon (1 gram) of HMF Super Powder supplies: Lactobacillus acidophilus (2 strains) ....... 6 billion CFU Bifidobacterium bifidum ......................... 1 billion CFU Bifidobacterium lactis ............................. 1 billion CFU Fructo-oligosaccharides ................................ 800 mg May contain up to ................................. 12 billion CFU
  • 17.  Intensive Phase  Intermediate Phase Take ½ teaspoon twice daily after Take ¼ teaspoon one or twice daily for meals for one month. Please note, for one month. more severe intestinal upsets you may safely take 1 Tablespoon twice daily.  Clinical Considerations Clinical Considerations  General illness (cold, flu, mild infection)  During and post-antibiotic use  Stressful life style  Acute intestinal upset (food poisoning,  Parasitic infections stomach ache)  Digestive problems (bloating, gas)  Digestive disturbances (bloating, gas)  Constipation  Candidiasis (yeast infections)  Excessive alcohol consumption  Bacterial Vaginosis  Bowel problems (constipation,  Parasitic infections diarrhea, IBS)  Chronic Fatigue Syndrome  Chronic Fatigue Syndrome  Bowel problems (constipation,  Candidiasis diarrhea, IBS)
  • 18. Genestra Brands Each vegetable capsule contains: Lactobacillus acidophilus (two human derived strains)....... 6 billion CFU Bifidobacterium bifidum.......1 billion CFU Bifidobacterium lactis.......1 billion CFU Fructo-oligo-saccharides (FOS)....... 200 mg May contain up to.......12 billion CFU *All HMF probiotics are gluten and casein free.
  • 19. Genestra Brands ~ Forte Tx recommendations Intermediate Phase  Maintenance Phase Take 4 capsules daily (2 caps twice 1 or more capsules daily after meals daily after meals) Clinical Considerations  Clinical Considerations  General illness  Maintain Health of the digestive  Stressful life style system  Parasitic infections  Prevention of colds and flu  Digestive problems (bloating, gas)  Stressful life style  Constipation  Digestive problems (bloating, gas)  Excessive alcohol consumption  Occasional Constipation  Bowel problems (diarrhea, IBS)  Prevention of Candidiasis & yeast  Chronic Fatigue Syndrome infections  Candidiasis
  • 20. Genestra Brands HMF Natogen (previously Neogen)  Ingredients and Suggested Use Each Scoop (100 mg) Contains  Lactobacillus acidophilus, guaranteed 1 billion CFU  Lactobacillus casei 1 billion CFU  Bifidobacterium infantis May contain up to 4.5 billion CFU  Lactose base (an important energy source for breast and bottle fed babies derived from milk but free of casein) Recommended Dosage Infants: Add one level scoop daily into the feeding, or dip your baby finger into scoop and give to infant to suckle on throughout the day. *All HMF probiotics are gluten and casein free.
  • 21. Genestra price list Probiotics & Prebiotics HMF______________________ 60 caps _ 10.50 HMF Forte _________________ 60 caps _ 15.00 HMF Forte ________________120 caps _ 27.50 HMF Neogen _________________ 6 g __ 10.50 HMF Powder_________________ 60 g __ 13.25 HMF Replete _______________ 7 sachets 17.25 HMF Super Powder ___________120 g __ 26.00 FOS + L-Glutamine___________ 60 caps _ 8.25
  • 22. Genestra Brands Seroyal, a Natural pharmaceutical company founded in 1984, manufactures and distributes the extensive line of Genestra Brands nutritional and botanical products and is the North American distributor for the renowned Unda Homeopathic line. Ask your registered practitioner for more information. Genestra Product Groups  Amino Acids & Proteins Antioxidants & Oral Chelations Botanical Combinations & Single Tinctures Calcium-Magnesium Complexes Digestives & Probiotics Essential Fatty Acids & Phospholipids Female & Prenatal Formulas Homeopathic, Endocrine & Glandular Extracts Minerals & Glucosamines Standardized & Phytonutrients Topical Care, Creams & Clinical Aids Vitamin-Mineral Complexes Vitamins A, C, E & B Complex<>
  • 23. Genestra philosophy Our products are based on scientific rationale using only the purest, highest quality, natural, raw ingredients available. We work closely with you and your peers to incorporate the latest research and clinical findings into all our products. Seroyal’s products are made with care and attention to every detail. To ensure product uniformity, each ingredient is accurately weighed, tested and precisely mixed. To retain the full healing properties of each component, all tablets are cold-pressed and a low pressure compressing process is used. This unique method does not involve the use of heat as is the standard practice in the industry. No lubricants or fillers are used during our encapsulation process whenever possible. We use the purest source of lubricant available, such as biodegradable vegetable cellulose, to maintain consistent capsule weight and content conformity. Genestra’s vegetable capsules are free of pesticides, preservatives and additives, tested by government- approved independent laboratories to ensure quick dissolution and disintegration. We guarantee that the disintegration time does not exceed 20 minutes from the time of ingestion for capsules, and 30 minutes for all our tablets. We regularly test our capsules and tablets to confirm weight variation and ingredient potency. When manufacturing the Genestra products, we follow the procedures outlined in the Good Manufacturing Practices. We ensure precision and objectivity during testing by contracting government-approved independent laboratories to assay and verify each ingredient for every product in each lot. We reconfirm each ingredient’s potency, weight variation, disintegration time and the absence of heavy metals, bacteria, E. coli, salmonella, yeasts, mold and other contaminants.
  • 24. About Genestra Brands Are HMF products shipped with an ice pack? No. But, after extensive product testing and new freeze drying technology performed by Genestra, it was concluded that the ice pack did not make a difference during shipping since the product potency was still well over 100% label claims when shipped with ice or no ice. The manufacturer states that it is no longer necessary to ship the HMF products with an ice pack for these reasons: Genestra has added in 50% more probiotic than what the label guarantees per bottle. For example, HMF Forte is guaranteed to have 6 billion L. acidophilus per serving, but there are 12 billion present at time of manufacturing and it is kept frozen until shipping. October 2004: The manufacturer has increased product stability again, allowing the probiotics to last up to 6 months at room temperature holding their GUARANTEED minimum potency on label! You will receive your HMF probiotic directly from the manufacturer in about 3-5 days. This product is very fresh and has not been sitting around on our shelves. And, you are guaranteed it will contain 50% more than what the label states. How do I travel with my HMF probiotics? We highly recommend you take your probiotics with you on all trips and vacations since their potency will last for up to 6 months at room temperature un-refrigerated. But, when possible and if convenient, we recommend you store your probiotics in the freezer or refrigerator, especially if you plan to preserve freshness of your product for months or years.
  • 25. What is Clostridium Difficile ( C.difficile )? Clostridium difficile, or C. difficile (a gram-positive anaerobic, SPORE forming bacterium)  Is now recognized as the major causative agent of colitis (inflammation of the colon) and diarrhea that may occur following antibiotic intake. C. difficile infection represents one of the most common hospital (nosocomial) infections around the world. Laboratory studies show that when C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhea and inflammation of the large intestine, or colon (colitis). This bacterium is primarily acquired in hospitals and chronic care facilities following antibiotic therapy (symptoms may be delayed until 6-8 weeks after antibiotic use). In addition to antibiotic use, chemotherapy and hospitalization, another risk factor for developing C.difficile diarrhea is simply advancing age. One study conducted in Sweden found that individuals older than 60 years of age are 20 to 100 times more likely to have C.difficile in their stools compared to 10-20 year olds (Barlett, 2002). Symptoms of C.difficile?  Symptoms of C.difficile diarrhea vary widely in severity. Some individuals experience recurrent mild-to-moderate diarrhea, wither others suffer from recurrent bouts of severe abdominal and back cramping, frequent loose and watery, greenish, foul-smelling stools, flatulence, fever, as well as variable amounts of mucus and blood in the stool. C.difficile diarrhea with accompanying inflammation of the colon can lead to toxic dilation of the colon, perforation of the colon, dehydration, loss of water volume, shock, and death. The toxins produced by C.difficile can also trigger a whole host of extra-intestinal complications, including joint pain and sleep disorders.
  • 26. C.Difficile Tx C.difficile be treated effectively? Although C. difficile infection usually responds to antibiotic treatment with metronidazole or vancomycin, approximately 20 to 25% of patients will experience re-appearance of diarrhea and other symptoms weeks or even months after initial therapy has been discontinued. When antibiotics are used to eradicate C.difficile, the antibiotics kill many of the “good” gastrointestinal flora species, but only kill non-spore forms of C.difficile. The C.difficile spores are still present. In order to eliminate C.difficile spores you need to have some “good” normal flora present. How can I re-establish my gastrointestinal flora to eliminate C.difficile ? Numerous of studies have proven certain probiotics to be a successful solution for recurrent C.difficile diarrhea.
  • 27. Saccharomyces boulardii Saccharomyces boulardii  A non-disease causing yeast that survives passage through the intestinal tract, unaffected by antibiotics (although it will be killed by antifungal drugs).  Based on preliminary data indicating that this yeast could prevent antibiotic-associated diarrhea.  Numerous studies, have gone on to prove Saccharomyces boulardii, as an effective treatment for active C.difficile diarrhea.  Saccharomyces boulardii disrupts toxins that would normally irritate the intestines,  In addition, Saccharomyces boulardii stimulates the intestinal immune system to secrete C.difficile toxin A-specific antibodies (IgA) in the gut (Qamar et al., 2001).  * It is then eliminated after supplementation is stopped.
  • 28. Allergy Research Group http://www.allergyresearchgroup.com/prod desc/category/microbal.htm
  • 29. Thorne Lactobacillus sporogenes Lactobacillus sporogenes represents a breakthrough in Lactobacillus supplementation a safe, stable, effective, L(+)-lactic-acid- producing organism. Lactobacillus sporogenes binds cholesterol in the gut, and may inhibit the cholesterol- producing enzyme HMG CoA Reductase. It requires no refrigeration or special handling.
  • 30. Resources http://www.rockwellnutrition.net/home.asp http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf Manufacture sites  http://www.seroyal.com/seroyal/Navigation/ProductLinePublic/Genestra_Line.htm  http://www.allergyresearchgroup.com/proddesc/category/microbal.htm  http://www.thorne.com/altmedrev/fulltext/micro.html  Microbial Ecology and Dysbiosis in Human Medicine ~ Excellent Article
  • 31. jefechi.com/probiotics