Quantifying Parkinson's Disease with a Wii

Quantifying Your Parkinson’s with a Wii QuantifiedSelf Paris May 22, 2012 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

Parkinson’s DiseaseA brief introduction

What is Parkinson’s Disease? Neurological degeneration of substantia nigra’s cells  Cells producing dopamine  Disease characterized by tremors, bradykinesia (slowness), rigidity  Diagnostic is currently only clinical (observation)  DaTScan can spot dopaminergic deficits and help differentiate with other disorders but is not an official base for a diagnostic  Only evaluation by a neurologist is recognized for diagnosis Looking for biomarkers – PPMI Michael J Fox Foundation’s initiative  DatScan measures?  Cerebral Spinal Fluid analysis?  Blood levels? 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

Causes of Parkinson’s We don’t know! But we know that  Dopamine producing cells in the Substantia Nigra (SN) degenerate  Basal ganglia cells do not receive enough dopamine and can’t perform their complex job for motor, and mood, processing loops  Motor alterations of movements is more and more pronounced, “potentially” until a bed-ridden stage  “Usually” leading to a constant degradation in Quality of Life 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

What’s the treatment? Compensate the loss of dopamine by supplying more levodopa, a precursor that is transformed in dopamine by the Substantia Nigra cells  Though, we can’t monitor directly the number of SN cells  We could see, thanks to a heavy procedure (DaTScan), the uptake of dopamine in basal ganglia improving  But mainly, we can see the improvement in motor condition  Which is the basis for an official diagnosis Exercise is also shown to be important (as potent as dopamine agonists, another drug class)  “Use it or loose it” situation  Probably improves uptake of dopamine  Put neuroplasticity in motion 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

The situation is Motor symptoms are the only easily observable impact of the disease  Depression is difficult to evaluate, and can be made worse by motor problems Every Parkinson’s patient is different  Mechanisms are extremely complex and idiopathies probably very different  Symptoms vary greatly among patients Levodopa has a short plasma half-life cycle (1 hour)  Should be taken several times a day  Proper doses throughout the day and adherence to schedule are critical 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

Why the Wii (or the Kinect, or theiPhone,..) can help? Helps you exercising Monitors your movements Provides measures or indexes that you can track (e.g. Wii-Fit age) Several studies are built on using the Wii to create physical exercises, and monitor their impact Wii has been an early (objective) indicator for a UK lady prior to her diagnosis Wii could serve to quantify objective measures among a large set of patients, and control group 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

Sara RiggareA woman with Parkinson’s Disease. Not patient but im-patient

2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND

2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND

2012 Sara Riggare – http://twitter.com/SaraRiggare2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND CC BY-NC-ND

When crowdfunding meetsquantified-selfClinical trials that patients consider important, at fractions of thecost

Crowdfunding clinical trials Using un-expensive material to monitor patient and control groups Opening the scope of hypotheses to be quickly tested  Exercise, dietary regimens  Existence of sub-types for the disease Big Data coming to medical research  23AndMe gathered genetic material from 6500+ people with Parkinson’s, leading to new correlations between certain genes and the disease  We could create a database of daily-living measures for symptoms and impact of drugs (are there compounds slowing down progression?) 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

If you’re interested in a crowdfundingchallenge for quantified-self trialsLet’s emulate #SciFund Challenge success. If you’re interested inseeing a similar Challenge for #quantifiedself #medicaltrials: Show this presentation around Contact me at fbaud@p2pventure.org 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

Quantifying Parkinson's Disease with a Wii

by FundMyMR on May 14, 2012

Accessibility

Categories

Upload Details

Usage Rights

1 Embed 1

Statistics

Quantifying Parkinson’s Disease with a Wii Presentation Transcript