Wound Care Management Technologies (Technical Insights)


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New wound care technologies that detect early wound healing and manage wound healing mechanisms are finding favor with physicians that are trying to determine suitable treatment protocols. Wound care management received a thrust from cost-effective and efficient technologically advanced products and therapies. Some wound care advancements that gained traction recently include wound dressings that offer controlled release of enzymes and antimicrobial agents, and silver nanocomposites that exhibit protective barrier and anti-inflammatory properties.

New analysis from Frost & Sullivan’s (http://www.technicalinsights.frost.com) Wound Care Management Technologies research finds that wound care therapy developers are increasingly responding to the demand for more effective wound care solutions. Biotechnology, biomaterial, and tissue engineering-enabled innovations are some of the fastest growing technology segments in this market.

If you are interested in more information on this research, please email Britni Myers, Corporate Communications, at britni.myers@frost.com, with your full name, company name, job title, telephone number, company email address, company website, city, state and country.

Published in: Health & Medicine

Wound Care Management Technologies (Technical Insights)

  1. 1. Wound Care Management Technologies (Technical Insights)Growth in the wound care management sector is expected to be driven bycompanies focused on elevating patient outcomes, lowering product costs, and delivering the advanced treatments necessary to heal wounds D4BE-TI
  2. 2. Wound Care Management Industry Outlook Globally, the active number of wound care patients is expected to more than double within the next three to four 1 years. This growth is being mainly influenced in part by an aging population and partly by an increasing amount of people with diabetes and obesity conditions, both of which delay the wound healing process significantly. The rise in prevalence of chronic wounds, that includes venous ulcers, diabetic ulcers, and pressure sores, has 2 led to more use of wound-care management approaches and device platforms. Wound care management platforms are believed to improve patient mobility, quality of life, and overall well-being of the individual. Conventional wound care approaches, such as wound dressings and ultrasound-mediated wound healing 3 products still constitute a majority of innovations being adopted in this sector, although advanced wound care approaches, such as nanodelivery of targeted therapies, silver nanocomposites for rapid wound healing, and detection platforms of early wound healing are helping drive growth in this sector. Emergent technology options to detect and diagnose early wound healing as well as properly manage the wound healing mechanisms are being increasingly developed. In order to determine suitable treatment protocols, 4 healthcare physicians are looking toward more advanced laboratory and diagnostic tests that are capable of assessing patient’ wound healing phase and the intermittent factors that adversely impact the wound healing process. Growth in innovations across wound care management sector is primarily being driven by technologically 5 advanced products and therapies that are much more clinically efficient and cost-effective than their conventional counterparts. Rapid growth in the global wound care management sector has led to very intense competition, with both 6 multinational companies and emerging start-ups vying to establish their wound management platforms and offer a comprehensive portfolio of products. Notable companies that are investing in wound management sector with increasing focus on widely used and cost-effective products includes DermaSciences Inc., Systagenix WoundSource: Frost & Sullivan Management, Smith and Nephew Plc, Covalon Technologies, and Synthes GmbH, to mention a few. D4BE-TI 2
  3. 3. Key Findings • Wounds whether of surgical origin or traumatic injury origin have to be closed in order to promote faster healing and reduce the occurrence of post-operative infections. • Wound care solutions targeting healing alone are not suffice, but effective wound care platforms that ensures uninfected and cosmetic results are preferred. • Wound healing phenomenon encompasses closely related stages, all of which focus on resurfacing, Market reconstitution, and regeneration of the tensile strength of damaged skin portions. This requires in depth Needs understanding by the wound care surgeons in order to facilitate the absence of scar formation. • Currently, wound healing industry is experiencing a paradigm shift from typical sutures, stapling devices, laser activation, surgical glues and adhesives to emergent biocompatible polymers, silver nanocomposites- based dressings, and tissue-engineered skin constructs. • Wound care armamentarium growingly includes many different treatment options and modalities wherein some of the products are updated and improved variations of previous treatments, while others are the results of innovations in entirely new fields of study. • Silver dressings since past several years have been noted for providing improved wound care, but newer forms of delivery aim to enhance the efficacy while at the same time reducing side effects. Emerging • Negative pressure wound devices are relatively new in wound care management, and the scope of disease Wound indications benefiting from this form of treatment are continually expanding to encompass aspects of Care wound management that previously had fewer options. Platforms • Advanced wound dressing products can help achieve an ideal wound environment to optimize wound healing conditions. With advent of biological skin grafts and tissue engineering, skin substitutes are being devised that not only provide effective temporary coverage of wounds, but are also involved in changing the paradigm of wound management. By well supporting the wound area with growth factors and biologic substitutes, it is envisioned that these emerging developments will help augment and even modulate the wound healing process by itself. • Hyperbaric oxygen treatment is also believed to provide improved wound care, especially in chronic wounds not responding to any other treatment option.D4BE-TI 3
  4. 4. Key Findings (continued) • The wound care management sector is witnessing a turmoil of changes in terms of novel biomaterials being employed as wound dressings. • Wound care advancements that have gained traction recently includes wound dressings incorporating Market controlled release of enzymes and antimicrobial agents; silver nanocomposites exhibiting protective Focus barrier and anti-inflammatory properties; honey-based wound dressings that have the potential to demonstrate antimicrobial, wound cleansing, and pain-free debridement properties; adoption of growth factors and tissue engineering constructs to promote wound healing; and lastly combination medical devices that assist in delivering targeted wound care therapy to ensure safe and timely closure of wounds. • Wound healing advances largely require innovations in wound healing approaches, which are capable of overcoming few delaying factors, such as infections, physical disabilities, suppressed immune system, and debilitating conditions, such as diabetes and obesity. Emerging • With novel wound healing treatments being designed rapidly, the higher wound care costs associated with Applications them is a point of major concern. • In the present-day healthcare settings, wound healing industry participants are aiming at developing technology approaches, which can significantly provide patient-compliant, cost-effective, and safer solutions to cure chronic wounds. • Rising preference for regeneration of tissues rather than just achieving wound closure has sparked interest in promising applications of wound healing technologies. • A few noteworthy technology applications that are gaining widespread adoption includes stem cell therapies for wound closure; tapping the advantages of growth factors and tissue constructs for achieving rapid wound healing with lesser side effects; and promising medical devices equipped with capabilities, such as nanodelivery of targeted therapies and electrical stimulation for ensuring safer closure of wounds. D4BE-TI 4
  5. 5. Wound Care Management Products–Responding to Demand • Venous ulcers are treated using compression therapy, debridement of necrotic tissues, and by offering a moist wound environment. Likewise, the treatment of diabetic foot ulcers necessitates the control of blood glucose levels, saline dressings that can provide moist wound environment, debridement, and evaluation. • Surgical wounds are treated using drug delivery-enabled wound closure devices and tissue sealants. Negative pressure wound therapy, tissue grafts, and applying recombinant growth factors to wound area are few other promising wound management techniques. • The treatment approach toward pressure ulcers requires prolonged surgical and primary care. • During such a prolonged treatment process, patients remain at risk for developing new pressure ulcers in other regions, so the treatment must be based on the staging of the pressure ulcer. Wound Care • Nowadays, doctors are focused upon debridement, topical wound care, treatment of Management infections, control of chronic wound contamination, and the use of support surfaces to enhance wound healing. • Chronic wound care typically begins with moist wound healing and moist wound Analyst Insights dressings are capable of creating an environment that ideally supports the cells needed for wound repair while at the same time preventing further damage.The most promising technologies for • Moist wound dressings are found to minimize the pain associated with dressingadvanced wound care identified to date are changes and offer much more cost-effective healing rates when compared to gauze- based wound dressings. A few moist wound healing dressing options that have beennegative pressure wound therapy and available for the past five to six years include alginates, hydrocolloids, foams,ultrasonic wound debridement systems. collagens, and hydrogels.Growth in both these wound management • Newer trend is geared toward creation of products that provide a moist and occlusivetechnologies sector is driven by solid environment, thereby paving the way for advanced wound dressings incorporatingevidence-based research. nanocomposites and bioengineered skin substitutes/gels. Source : Frost & Sullivan D4BE-TI 5
  6. 6. Wound Care Management–Innovation CapabilityOther Emerging Wound Management Technologies Recombinant growth Usage of silver and factors and tissue combination dressings scaffolds for wound closure Pressure relief devices Therapeutic that enable tissue ultrasound perfusion Notable emerging wound care Wound closure devices management technologies Nanotechnology-enabled providing non-invasive drug delivery to wounds wound healing Many of technological advancements in wound care management sector are concentrated across innovations in advanced wound management, wound closure devices, and pressure-relief devices. Advances in wound management products are noted to be an expanding sector with opportunities designed for treatment of both acute and chronic wounds. Source : Frost & Sullivan D4BE-TI 6
  7. 7. Wound Management Technologies–Noteworthy Trends These days advanced biological materials are available in the form of enzyme preparations and mechanical debridement tissue scaffolds that help remove dead Cost Effective Wound cells. Potential benefits to patients by utilizing such advanced biological materials Management includes fewer reapplication of dressings, lesser discomfort and pain, much faster healing, and reduced risk of complications that includes infection and amputations. This enables cost-effective treatment to be achieved. With product innovation spurs in drug delivery approaches for wound care Wound Care Drugs and management, more and more patients will leave the hospital sooner without post- Biologics surgical wounds and traumatic wounds that are not healed. This shift will ensure an increase of at-home and extended care wound healing initiatives to be provided outside of a sterile environment. Wound care companies that are most successful in advanced wound management Increase of Home and sector are those that find ways to innovate around wound care and healing. These Extended-care Wound firms are engaged towards development of products that enable rapid wound healing Treatments within home settings and at the same time decrease the risk of hospital-acquired infections significantly. Source : Frost & Sullivan D4BE-TI 7
  8. 8. Snapshot of Wound Care Innovations Snapshot of Pioneering Wound Care Drugs and Biologics Wound Care Drug/Biologic and Drug Developmental Developer Targeted Indication Class Status Human active recombinant Phase 3- approval Renovo Group Plc Juvista injectable solution for prevention and transforming clinical studies are Manchester, UK reduction of scarring growth ongoing factor beta-3 inhibitor Biotec Pharmacon ASA Biogel with Biotec BetaGlucans ASA Woulgan Biogel for treatment of painful ulcers active beta- Phase 3-approvalclinical Norway and slow-healing wounds glucan studies are on-going component Completed Phase 2 & Phase 3 clinical studies Enzymatic MediWound Limited and its marketing NexoBrid for wound debridement and healing debriding Tel Aviv, Israel authorization application agent is currently under review Capstone Therapeutics Synthetic AZX100 for the treatment of dermal hypertrophic Completed Phase 2 Corp. 24-amino scarring clinical studies Tempe, Arizona acid peptide Source : Frost & Sullivan D4BE-TI 8
  9. 9. Forthcoming Technology Innovations and their Impact Potential Technologies to Look Forward to within the Next Three-five Years Industry Impact Short Term Long Term Therapeutic ultrasound platforms to accelerate wound healing– Targeted slow-release ultrasound The effects of targeted slow release ultrasound to help initiate a biological response at the cellular levels have been realized to be a potential platform stimulating vascular endothelial growth and cell proliferation. Therapeutic ultrasound platforms that allow for a portable electronic driver and disposable ultrasound patch to accelerate wound healing process appears to be a promising technology that sets an innovation class of its own. The ultrasound technology development allows High High PainShield therapeutic for complementing existing systemic methods of oxygenation and will also ultrasound product facilitate greater therapeutic versatility in treatment of wounds, possible in Picture credits: NanoVibronix Inc. (Tel Aviv, Israel) home care settings within the next few years. Translation of therapeutic ultrasound platforms as potential non-invasive wound therapy is envisioned to have a huge impact within the next three to four years. Next-generation nanofabricated meshes & biomaterials- Usage of polymeric nanofibers have been cited to impart surgical meshes with unique material properties in various clinical studies conducted so far. Unique material properties imparted are the following: soft, compliant cloth- like feel, and biological properties that include rapid cellular ingrowth and accelerated wound healing, all of which make these nanofibers ideal for Medium High surgical use. Extensive academic research has been able to establish the fact that nanotechnology-based platforms allow for the manipulation of variables such as varying order, alignment, and thickness, thereby yielding Nanostructured surgical customized surgical meshes for each clinical indication targeted. The meshes Picture credits: Retectix application impact of nanotechnology platforms as mesh substitutes and LLC (St. Louis, Missouri) synthetic biomaterials for wound healing is envisioned to be recognized within 2015. Source : Frost & Sullivan D4BE-TI 9
  10. 10. Impact Assessment of Technology AcceleratorsDrivers 2010 2012 2014 Optimization of wound care is often considered to be the most important parameter because it is often the crucial possibility existing to facilitate healing. This, in turn, depends mainly on the application Medium High High of the right product at the given time, thereby paving the way for innovations to spearhead successful wound healing. With the Emphasis on increased understanding of wound biology, major improvements in modern wound management wound dressings are nowadays feasible. Modern wound management outlook has shifted toward focused efforts on improving wound healing mechanism as well as enhancing the patient’ quality of life. The interest generated toward identifying and designing novel wound dressings which provide good control of adsorption and fluid handling properties acts as a major driving force for best practices to be adopted across wound management. It can be observed that the number of hospital-acquired infections Rise in hospital- has spurred the development of antimicrobial technologies for chiefly acquired safeguarding the exposed wounds from bacterial exposure. High Medium Medium infections has Emergence of antimicrobial dressings that are chiefly made of accelerated usage of silicone and nano impregnated materials is becoming the standard of advanced wound care amongst physicians these days. Widespread adoption of dressings antimicrobial dressings for wound healing application acts as a steering force for emphasizing the prevention of wound development in long-term care settings. Source : Frost & Sullivan D4BE-TI 10
  11. 11. Potential Technologies—Opportunity Analysis Sector Level of Attractiveness Probability of Success Therapeutic ultrasound- • The demand for wound care platforms that • Ultrasound technology uniquely utilizes surface acoustic enhanced wound provide a greater therapeutic versatility in waves that are implemented within a thin transducer to treating wounds serves as the key factor for allow for effective ultrasound therapy to be delivered management this technologys higher level of attractiveness. around the application site (wounds). Low-frequency sonophoresis has been well documented to enhance the permeability of skin to drugs and patches. • The potential behind surface acoustic waves technology is huge in terms of facilitating the delivery of oxygenated saline at an appropriate depth in wound bed and physiologically effective in promoting angiogenesis and Misonix Sonic One ultrasonic wound care system collagen formation. Picture credits: Misonix Inc. (Farmingdale, New York) • Wound care standards have constantly evolved • The rising number in elderly patient population and their from surgical drapes and conventional wound impact on healthcare expenditure suggest a higher Nanocomposites and dressings to present-day advances in terms of adoption potential of nanocomposites and silver-based silver-based advanced nanocomposites and silver-based dressings. wound dressings. wound dressings • Wound dressing platforms have evolved from • The strategy going forward would be identification and hydrocolloid platform to more advanced delivery of best available wound care while at the same polymer and biomaterials-based dressings that time limiting complications and associated treatment impart antimicrobial or analgesic properties to costs. wound area. Silver and nanocomposites-based dressings have been integrated as part of modern wound management due to efficient control of bacterial load and local infection combating properties. Antimicrobial silver-based wound dressing Picture credits: B. Braun AG (Germany) Source: Frost & Sullivan. D4BE-TI 11
  12. 12. ContactBritni MyersFrost & Sullivan 210.477.8481 Britni.myers@frost.com D4BE-TI 12