Cancer Therapies:
Getting Targeted and More Personalized
Sangeetha Prabakar, Industry Analyst
Technical Insights, Healthcare
9th September 2008

Scope of the Analyst Briefing
An overview of cancer therapies
Emerging trends in cancer therapies
Overview of the factors influencing the future of cancer therapies
Key opportunities for cancer research
Drivers, restraints and challenges affecting cancer therapies
Technology road map
Noteworthy technologies and products
2

Areas of Major Advances
Nanotechnology
3

Diagnostics
Companion Diagnostics
Prognosis
Real Time Screening
Drug Toxicity
Drug Response Monitoring
Prediction of Recurrence
Pharmacogenomic Studies
Microarrays
4

Therapeutics
Targeted Therapy
Monoclonal Antibodies
Enzyme Inhibitors
Proteasome Inhibitors
Angiogenesis Inhibitors
5

Drug Delivery
Targeted Delivery
Liposomes
Nanoparticles
Nanodrug Implants
Polymer Drug Conjugates
6

Future Paradigm of Cancer Care
Personalized Personalized
One drug for a
One drug for a care – Patient care – one pill
specific
single phenotype specific drug for individual
population
cocktails patient.
Medium
Low High
Molecular Diagnostics
Microarrays
Targeted Therapies
Nanotechnology
Drug Delivery Technologies
7

Future Economic Trends in Cancer Care
Molecular Profiling
Molecular Phenotype
Tumor Genotype
Tumor Subtype
Disease Stage
Personalized Medicine
8

Growth Drivers for Cancer Drugs
9

Growth Restraining Factors for Anticancer Drugs
Complicated Nature of
Chemotherapy
Side Effects of
Chemotherapy
Inadequate Data on
Cancer Subtypes
Multiple Drug Resistance
Inherent Features of
Cancer Cells Complicate
Drug Targeting
Poor Target
Specificity/Poor Drug
Solubility
Insurance/High
Costs/Tough Regulatory
Environment
Expiring Patent/Generic
Threat
Need for Regionalization
of Clinical Trials
Growth Restraining Factors for
Anticancer Drugs
10

Emerging Cancer Research Opportunities
11

Key Players and Their Innovations
12

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