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NanotextNL, programa de innovación holandés en nanotecnología
 

NanotextNL, programa de innovación holandés en nanotecnología

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Presentación de Dave Blank, director científico de MESA+Instituto de Nanotecnología de la Universidad de Twente (Países Bajos) durante las jornadas sobre nanotecnología organizada por Grupo ...

Presentación de Dave Blank, director científico de MESA+Instituto de Nanotecnología de la Universidad de Twente (Países Bajos) durante las jornadas sobre nanotecnología organizada por Grupo FORMAR-SE.

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  • MESA+ institute -> ideas, IP, employees (MSc, PhD), research partner
  • Micronit makes glass microfluidic chips for analysis of fluids Life-sciences markets : diagnostics, biotechnology, farmacy At the moment only prototyping Market demand for high volume chips De heren ir. Micha Mulder en ir. Ronny van ’t Oever zijn uitgeroepen tot ‘Ingenieur van het jaar 2007
  • Ir. Erik Staijen, afgestudeerd in EL, viert de verkoop van de eerste 100 Blue4Green systemen aan veeartsen. Ir. Erik Staijen, afgestudeerd in EL, viert de verkoop van de eerste 100 Blue4Green systemen aan veeartsen.
  • An ultrasensitive sensor for rapid detection of micro-organisms such as viruses and bacteria, and biomarkers has been developed at the MESA+ Institute based on a Lab-on-a-Chip Interferometric Nanotechnology. This sensor has been quoted by Forbes.com as one of the “ 13 Amazing New Nanotechnologies ” worldwide! The essential innovation in this technique is the combination of an integrated optics interferometric sensor with antibody-antigen recognition approaches. The sensor basically consists of a laser, which is shone through an optical chip on which several measuring and reference channels are located . To spot a particular virus (or any other analyte), the appropriate antibodies are immobilized onto one of the measuring channels and then a sample containing the virus is flowed through that channel. If the virus particles bind to the antibodies, the interference pattern of the light, which is recorded on a CCD camera, changes, allowing estimation of the concentration. The sensor is able to spot the Herpes virus at concentrations of just 850 particles per milliliter under physiological conditions in a few minutes. The sensitivity of the sensor approaches detection of a single virus particle, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics. Detection of other types of viruses, bacteria, cells and biomarkers in complex mediums has been performed as well. The technology is amenable to miniaturization and mass-production, and thus has significant potential to be developed into a handheld, point-of-care device.
  • Aurel Ymeti en Alma Dudia with their prototype virusdetector

NanotextNL, programa de innovación holandés en nanotecnología NanotextNL, programa de innovación holandés en nanotecnología Presentation Transcript

  • Prof. Dave H.A. BLANK Scientific Director MESA+ institute for nanotechnology, NL Chairman NanoNextNL, Dutch initiative on nanotechnology Board NanoNed
  • [email_address] www.mesaplus.nl
  • MESA+ Institute for Nanotechnology
    • Combines nanotechnology, microsystems and materials science research at the University of Twente
    • Staff
      • 550 people, 34 research groups
    • Yearly turnover
      • 45 M€ with 60% from external sources
    • Mission
      • excelling in its research field
      • exploring new research themes
      • educating researchers and designers in its field
      • commercializing research results
      • initiating and participating in fruitful (inter)national collaboration
  • Three pillars of MESA+ Excel in Science Publications Citations Grants (International) collaboration Commercialization Spin-offs HTFactory HTFund (International) collaboration Infrastructure NanoLab Roadmap Research Lab’s (International) collaboration
    • Micromachining, Microengineering, MEMs & NEMs technology
    • Nanoelectronics, Nanodevices, Functional Thin Films, Computational Materials Science
    • BioNanotechnology, Self Assembly, BioMolecular Science, Polymer Science
    • Nanofluidics, Lab-on-a-chip, Micro- & Nanoreactors, Membranes
    • Photonics, Optical Devices, Laser Physics
    • Strategic Research Orientations
    • Multidisciplinary: combining at least 5 strong research groups from 2 disciplines
    • Top-level scientific publications
    • Attractive for external funding
    • Headed by an independent scientist
    • SRO’s:
    • NanoMaterials for Energy
    • Nanotechnology for Innovative Medicine
    • Applied NanoPhotonics
    • Enabling NanoTechnologies
    • Risk analysis, Societal & Ethical Aspects of NanoScience and –Technology
    Research Activities
  • MESA+ NanoLab
    • Facilities
      • 1250 m2 cleanroom
      • materials analysis laboratory
      • specialized group laboratories
  • 5 November 2010
  • Commercialisation
    • Cooperative environment
      • > 40 spin-off companies
      • joint projects
    • Business support
      • business development team
      • MESA+ Technology Accelerator
    • MESA+ Tech Park
      • facility sharing (cleanroom & lab)
      • High Tech Factory (production)
    • Finance
      • High Tech Fund (lease)
      • Twente Tech Fund (investment)
  • U-Needle UT International Ventures
  • DUTCH INITIATIVE FOR HIGH-TECH SYSTEMS AND MATERIALS TOWARDS SUSTAINABLE OPEN INNOVATION
  • History
    • ‘ Selective continuation’ of NanoNed and MicroNed
      • NanoNed: research program on nanotechnology (2004-2010; 200 Meuro)
      • MicroNed: research program on microtechnology (2004-2011; 50 Meuro)
    • Based on the Strategic Research Agenda Nanotechnology of the Netherlands Nano Initiative (SRA-NNI)
      • NNI: co-operation of science foundations STW, FOM and NanoNed
      • Part of the vision & action plan of the Dutch Cabinet on nanotechnology
      • SRA is collaboration between industry, knowledge institutes and government
    • FES High Tech Systems & Material proposal “Towards an Open Innovation Eco System”
      • Initial proposal: October 2009
      • Approved by Dutch Cabinet: 2010
      • Start: February 2011
  • Context: Micro- en Nanotechnology Nano – Micro – Systems: a continuum
  • Coherence
    • 1. “Toolkit” Themes
    • Building set of unique micro/nano capabilities
    • Enabling economic growth
    • Enhancing each other (synergies)
      • 1. Risk analysis and TA
    • 3. “Risk and TA” Theme
    • Responsible introduction of new technology
    • Own economic growth potential
    • Technology Assessment
    • 4. “Competencies Program” and governance model
    • Supporting interactions and cross-fertilization
    • Valorization, Communication and Program Management (STW NanoNextNL Program Office)
    6. Beyond Moore 7. Nano materials 8. Bio-nano 9. Nano fabrication 10. Sensors and actuators 2. Energy 5. Food 3. Nanomedicine 4. Clean water
    • 2. Application Themes
    • Key societal challenges
    • Supporting other Dutch “Key Areas”
    • Enabling economic growth
  • Facts & Figures
    • Starts in 2011; Ends in 2016
    • Budget: 250 (key programme)+ 50 (ifrastructure) million euro
      • Dutch government-contribution: 125 million euro
      • Partner-contribution: 125 million euro
      • Infrastructure: 50 million euro
    • 28 programmes (structured within 10 Theme’s)
      • about 300 projects
      • in each projects several partners
    • 114 partners
      • 11 Universities
      • 13 knowledge institutes
      • 9 medical centre
      • 81 companies, about 70 SME’s
    • Legal Representative (Dutch: ‘penvoerder’): Foundation NanoNextNL
    • Programma Office @ Technology Foundation STW
  • Goals NanoNextNL
    • Joint innovations for and with about 80 companies
      • Applied in competitive R&D in parallel with HTS&M and as follow-up
    • 115 patents (first filings)
    • 300 new trained researchers available to industry and academia
    • Solutions for key societal issues such as:
      • Improved and costs-effective healthcare
      • Healthy food and its production
      • Clean water
      • Producing green energy
      • Reducing energy consumption
    • Internationally leading scientific position in micro- and nanotechnologies
    • Open Innovation Ecosystem that will continue to innovate after 2016
      • Linking HTS&M industry to other areas of economy
      • Linking industry, research institutes and universities
      • Linking multinational, large companies and SME’s (instead of separate SME compartment)
      • Finding EU partners
    • Large companies such as:
    • AKZO-Nobel, ASML, Avebe, BASF NL, Danone, DSM, Dutch space, FEI, Ferro BV, Friesland Foods, Huntsman, IBM/Hitachi, Merck, Nikon, NXP, Norit, Nuon Helianthos, NXP, Oce, PANalytical, Philips, Shell, Solland, Solvay, Umicore, Unilever, Vitens, Zeiss
    • SME’s such as:
    • Aemics, Aquamarijn, ATAS-GL, Bactimm, Baseclear, Bioconnection, Boschman, Bronkhorst, C2V, CCM, Chemtrix, Chess, Cosine/TSST, Culgi, Demcon, Demcon BV, Devlab, Encapson, Flowid, Fluxxion, FutureChemistry, IMT, Innosieve, ISIS, Kreatech, Lionix, MA3, MAPPER, MecWinn, Medspray, Membryon, MicroDish,  MicroDish, Micronit, Nanolab, Nanomi, Nanosens, Novataris Vaccine, Pepscan, PhoeniX, Polymer Vision, Progentix, Smarttip, SolMateS, Synthon, SystematIC, Tembo, TWMS, Tytonis, Veeco
    • Institutes and Centres such as:
    • ASTRON, BIOMADE, FOM Amolf, FOM Rijnhuizen, Holst Centre (TNO, IMEC), KWR, NCLR, PRI, (medical centres:) LUMC, KIT, RUN UMC
    • Universities such as:
    • LEI, RU, RUG, RUN, TU/e, TUD, UT, UU, UVA, VU, WUR
    • Total 300 Meuro with commitment of 50% of program budget
    Consortium
  • MESA+ (Utwente,), TUDelft, RUGroningen, TU/e
  • Impact of Nanotechnology: Lab on a Chip 2010 Na Li 1992 2006
  •  
  •  
  •  
  • Lab-on-a-Chip Interferometric sensor prof. Vinod Subramaniam group
    • Detection of one micro-organism
    • such as 1 virus particle
    • Results in 5 minutes
    • Small sample volume (  l)
    • Potential for a handheld device
  •  
  • UT International Ventures Portable detector Listeria, Salmonella and B. cereus bacteria in raw milk; Herpes and Vaccinia virus in serum; Troponin I (biomarker cardiac injury) detection Potentials: tumour markers; Tuberculosis and MRSA diagnosis
    • Proof of concept in collaboration with:
    • - Medisch Spectrum Twente Hospital
    • St. Radboud Hospital
    • Spiez Labor, Switzerland (Swiss Army/UN)
    • Zwanenberg Food Group
    • Jeroen Bosch children’s hospital /WUR
    Cost price ~ € 5,000
  • PiezoMEMS structures Side view Top view SRO bottom electrode PZT layer SRO top electrode
  • MESA + Institute for Nanotechnology Inorganic Materials Science Industrial scale pulsed laser deposition 4 – 8”
  • DUTCH INITIATIVE FOR HIGH-TECH SYSTEMS AND MATERIALS TOWARDS SUSTAINABLE OPEN INNOVATION