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Definition & types of jaundice
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Definition & types of jaundice

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Definition & types of jaundice

Definition & types of jaundice

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  • 1. Definition & Types of Jaundice
    By: Fahad Al Hulaibi
  • 2. :Definition
    Jaundice is a yellow discoloration of the sclerae and skin, as a result of raised serum bilirubin, and is usually detectable clinically when the bilirubin is greater than 3mg/dL.
    Clinical Medicine, Kumar & Clark, 4th edition
  • 3. Types:
    1- Haemolytic jaundice
    2- Congenital hyperbilirubinemia.
    3- Cholestatic jaundice.
    Clinical Medicine, Kumar & Clark, 4th edition
  • 4. Type 1:Haemolytic jaundice
    The increased breakdown of red cells
    leads to an increase in production of bilirubin.
    causes of haemolytic jaundice are those of haemolyticAnaemia.
    The resulting jaundice is usually mild.
    level of unconjugatedbilirubin is raised,
    but the serum transferasesand alkaline phposphateare normal.
    Clinical Medicine, Kumar & Clark, 4th edition
  • 5. Type 2:Congenital hyperbilirubinemia
    Most common is Gilbert’s syndrome .
    Mutation in the gene coding for :
    UDP-glucuronosyltransferase.
    asymptomatic and is usually detected as an incidental finding of a slightly raised Bilirubin (1–6mg/dL).
    There is a family history of jaundice in 5–15% of patients.
    The reticulocyte count is normal, excluding haemolysis, and no treatment is necessary.
    Clinical Medicine, Kumar & Clark, 4th edition
  • 6. Type 3:Cholestaticjaundice
    Can be devided into:
    Intra-hepatic Cholestatic:
    Cased by hepatocellular swelling in parenchymal liver disease or abnormalities at a cellular level of bile excertion.
    aminotransferasesand alkaline phposphate ??
    Extra-hepatic Cholestasis:
    Resulting from obstruction of bile flow at any point distal to the bile canaliculi.
    Clinical Medicine, Kumar & Clark, 4th edition
  • 7.
  • 8. Thanks