Session 1: Frenkel’s legacy: what is keeping us?
by Food and Agriculture Organization of the United Nations on Oct 29, 2012
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In 1947, Dr. H. S. Frenkel reported growth of Foot and Mouth Disease (FMD) virus in cultured explants of cattle tongue epithelium. This method was subsequently developed for large-scale production of ...
In 1947, Dr. H. S. Frenkel reported growth of Foot and Mouth Disease (FMD) virus in cultured explants of cattle tongue epithelium. This method was subsequently developed for large-scale production of the virus, thus creating possibilities for FMD vaccine production on a much wider scale than hitherto. Frenkel-type vaccines were first used for large scale cattle vaccinations in the Netherlands in 1953. The number of FMD cases dropped dramatically, but rose again in the early 60-ties, especially in pigs. It was not until the late 60-ties, when the neighboring countries started to vaccinate routinely, that FMD disease was gradually brought under control. The lessons from this early experience are twofold: first FMD can be controlled, even with the classical vaccines in countries with a dense population of susceptible animals, and second such efforts are best undertaken as part of a regional approach. In other regions the lessons learned were similar, for instance in South America where remarkable progress with FMD control has been achieved.
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