FMD SITUATION IN TURKEYA. Naci BULUTHead of the Diagnosis DepartmentŞAP Institute, Ankara, Turkey            West EurAsia ...
Strategic FMD Control PlanRegulation relating to the FMD•   Directive for Control of FMD has been come into force., to bre...
Analysing Socio-economic impact and risk Surveillance has been designed as part of 2012 Autumn  Serosurveillace, aimed to...
FMD Control Strategy Conducted in Turkey1. Vaccination•   New vaccination strategy based on risk analysis has been initiat...
Results of SurveillanceIDENTIFICATION OF CIRCULATING STRAIN• FMD is endemic in Anatolia region in Turkey• Current Circulat...
2012 Anatolian Outbreaks; distribution by serotype and month                                                         2013 ...
Map Disribution for 2012 Anatolian Outbreaks                            Anatolian Outbreaks for Second Half of 2012       ...
Map Distribution for 2013 Anatolian Outbreaks                                      O Tipi                                 ...
GENETIC CHARACTERIZATON FOR 2012 AND 2013 FIELD ISOLATES                            2012                       Serotypes  ...
Distribution of Sublineages of Type O PanAsiaII/FAR09/GUM-13 isolates sampled in 2012-2013 by timeline and georaphicallyAr...
Distribution of Sublineages of Type A Iran05/SIS10/BAB-12  isolates sampled in 2012-2013 by timeline and georaphicallyJuly...
Anatolian Serosurveillance•      A NSP Serosurveillance has been conducted in Anatolia region in Autumn 2012•      Objecti...
Results for Anatolian 2012 Autumn Serosurveillance-Cumulative0-3% 3-5% 5-8%   8-10% 10-15% 15-20% 20-30%   30-40% 40-50% >...
Results for Anatolian 2012 Autumn Serosurveillance-Large Rum                                 Results for Anatolian 2012 Au...
Vaccination for 2012 and 2013         West EurAsia FMD
Vaccination Policy Used for Spring Vaccination                  campaignMap Distribution for Spring Vaccination           ...
Vaccination campaign for Autumn 2012       Provinces vaccinated with Trivalent vaccine by campaign       Ring vaccination ...
Vaccine used for 2012 Sring vaccination campaign    Campaign vaccination: 1,985 million doses Trivalent vaccine    Ring ...
Regions included vaccination and allocated             vaccine for Spring 2013 CampaignRegions have been included in Sprin...
Map Distribution to be implemented Spring2013 Vaccination Campaign       LR vaccination as campaign       Ring vaccination...
Critical assessment on if strategy is achieving the goal    – Are control measures reducing FMD impact?Yes; Serosurveilla...
Plans related to FMD surveillance and control in the                     short and long term.Short term Plan for Surveilla...
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Foot-and-Mouth Disease situation in Turkey

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This PPT concerns the Strategic FMD Control Plan and an analyses of Socio-economic impact and risk. The FMD Control Strategy Conducted in Turkey is also outlined, as are the Results of Surveillance . The Vaccination for 2012 and 2013 is detailed.

A. Naci BULUT
Head of the Diagnosis Department
ŞAP Institute, Ankara, Turkey

“Presentation made during an FAO event. Content does not directly reflect any official position of FAO staff.”

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Foot-and-Mouth Disease situation in Turkey

  1. 1. FMD SITUATION IN TURKEYA. Naci BULUTHead of the Diagnosis DepartmentŞAP Institute, Ankara, Turkey West EurAsia FMD Control-Roadmap 2025, 4th Annual Regional Progress Review Meeting, 2-4th April 2013, Baku, Azerbaijan
  2. 2. Strategic FMD Control PlanRegulation relating to the FMD• Directive for Control of FMD has been come into force., to breakthrough failing points of the control measures, it has been initiated some work plans based on requirements of the directive: – Reconstruction TURKVET database – Launching Sample Management System (SMS) under the TURKVET – Some advanced measures on control of animal movement and trade • Registration and training of the animal dealers • Transportation Animal Vehicles with effective bio-secure conditions based on Animal Wellfare Directive • Movement of animals with ensured immunity level – A interactive epidemiology training has been initiated for field vets by Şap InstituteVaccination Strategy• New vaccination strategy based on risk analysis has been initiated, since it has been insufficient vaccine resourceThrace Region Surveillance Program To detect risk as possible early, more sensitive surveillance program has been launched in Thrace Region by donation EC and expertise EuFMD  Regular active surveillance (clinical examination)  Serosurveillance in the area where was identified as high risk per three month  Management advanced passive surveillance
  3. 3. Analysing Socio-economic impact and risk Surveillance has been designed as part of 2012 Autumn Serosurveillace, aimed to analyse risk and socio-economic impact. Stage of collecting information has been finalized between October2012-January1013 Aimed three basic analysis: – Impact of animal movement and animal trade pattern on disease dynamics and role of milk collectors for disease transmission – Impact of animal husbandry system on disease dynamic ; Role of SR for disease transmission – Impact of vaccination on control of the disease; between where vaccination apply and species Data cleaning and analysing have been continued, results will be available soon
  4. 4. FMD Control Strategy Conducted in Turkey1. Vaccination• New vaccination strategy based on risk analysis has been initiated, since it has been insufficient vaccine resource, since it has been insufficient vaccine resource: – Preventive campaign vaccination; acc.to risk analysis developing a vacc.program before each campaign- where /which species vaccine apply • LR; twice a year, vacc not apply as campaign in Anatolia;_In Thrace: LR: Twice a year/SR: once – Ring Vaccination to response outbreak in Surveillance zone of outbreak – Targeting vaccination for “Hotspot”; extending ring vaccination with specific serotype2. Diagnosis and Genetic and Antigenic Characterization of Isolates3. Epidemiological investigation _ Active and passive surveillance – Outbreak investigation and case study – Serosurveillance; NSP Prevalence estimation in Anatolia/Disease detection in Thrace4. Routine control measures in case of disease outbreak (biosecurity, restriction, quarantine, sampling)5. Control of animal movements and markets6. Training vets and awareness activities7. Vaccine effectiveness study to evalute vaccine used and application of vacc.
  5. 5. Results of SurveillanceIDENTIFICATION OF CIRCULATING STRAIN• FMD is endemic in Anatolia region in Turkey• Current Circulating virus strains: – Serotype O (O PanAsiaII), – A (A Iran05) and – Asia-1(Asia1/SINDH08)• 1038 outbreaks recorded in Anatolia in 2012; 847 out of them were serotyped by national reference lab, 90 were untyped (virus not detected or only positive FMD), 101 were reported by clinical diagnosis.• In 2013, up to 20th March, 131 outbreak were recorded and serotyped
  6. 6. 2012 Anatolian Outbreaks; distribution by serotype and month 2013 Anatolian Outbreaks 5, 4% 13, 10% 14, 11% 53, 40% Type O Type A 46, 35% Type Asia-1 FMD(+) Unserotyped West EurAsia FMD n131
  7. 7. Map Disribution for 2012 Anatolian Outbreaks Anatolian Outbreaks for Second Half of 2012 West EurAsia FMD
  8. 8. Map Distribution for 2013 Anatolian Outbreaks O Tipi A Tipi Asia1 Tipi West EurAsia FMD
  9. 9. GENETIC CHARACTERIZATON FOR 2012 AND 2013 FIELD ISOLATES 2012 Serotypes 2012 Grand O A (AIRN Asia 1- total (PanAsia 05) Sindh08Sub-groups II) O ANT-10 1 1 O BAL-11 5 5 O FAR-09 49 49 A-SIS-10 24 24 A USK-11 13 13 2013 A AMS-12 50 50 Serotypes Grand A WES-11 2 2 A (AIRN O (PanAsia total Asia 1-Sindh08 A KES-12 9 9 Sub-groups 05) II) A BAB-12 9 9 O FAR-09 8 8 Asia1- O PanAsiaII/FAR- 79 79 16 16 Sindh08 09/GUM13Asia1-Sindh- A-SIS-10/A AMS-12 3 3 6 6 A-SIS-10/A BAB-12 13 13 08ERN-12 Grand Asia1-Sindh08 2 2 107 55 85 277 Grand Total 16 24 2 42 Total A-SIS-10/A BAB-12 is new incursion detected on November; O FAR09/GUM is also considered as exotic but not found indication yet West EurAsia FMD BY ŞAP INSTITUTE
  10. 10. Distribution of Sublineages of Type O PanAsiaII/FAR09/GUM-13 isolates sampled in 2012-2013 by timeline and georaphicallyAralık 2012Ocak 2013Şubat 2013Mart 2013 BY ŞAP INSTITUTE West EurAsia FMD
  11. 11. Distribution of Sublineages of Type A Iran05/SIS10/BAB-12 isolates sampled in 2012-2013 by timeline and georaphicallyJuly 2012August 2012September 2012October 2012November 2012December 2012January 2013February 2013March 2013 BY ŞAP INSTITUTE West EurAsia FMD
  12. 12. Anatolian Serosurveillance• A NSP Serosurveillance has been conducted in Anatolia region in Autumn 2012• Objective: Estimation of NSP prevalence and risk analysis• Species: LR (Cattle and W.Buffalo); SR(Sheep and goat)• Sample Frame: 31 LR and 32 SR per epi unit, 64300 sera in 1027 epi units; collected sera: 61605• Brief Results: – Cumulative prevalence: 21,84% – LR: 15,82%; SR: 23,78% (Sheep: 25,68%; Goat: 15,55%)• Some initial remarks for results:-High prevalence was estimated in east region-Because of impact of Asia-1 outbreaks, higher prevalence was estimated in west area when compared with1010 Surveiallance-Higher prevalence was detected in Sheep rather than cattle and goat, but west area sheep prevalence also waslow than east area-poor outbreak reporting was detected in the east; Region Prevalence- Prevale Prevale Cumulative nce-LR nce-SR -Husbandry system and movement pattern Blacksea 9,3 8,30 9,57 was effected on transmission dynamic, 26,74 40,34 East Anatolia 40,22 population density particularly in the west not 13,77 23,47 Inner Anatolia 20,52 related to directly 12,28 7,6 Marmara and Eagean 10,76 -not detected any finding on transmission 6,6 14,87 Meditterinian 11,78 between species; neg NSP for LR despite 15,61 28,67 SouthEastern Anatolia 24,78 high pos rate for SR in the same epi-unit 15,0 23,5 TOTAL 21,0
  13. 13. Results for Anatolian 2012 Autumn Serosurveillance-Cumulative0-3% 3-5% 5-8% 8-10% 10-15% 15-20% 20-30% 30-40% 40-50% >50%
  14. 14. Results for Anatolian 2012 Autumn Serosurveillance-Large Rum Results for Anatolian 2012 Autumn Serosurveillance-Small Rum.0-3%3-5%5-8%8-10%10-15%15-20%20-30%30-40%40-50%>50%
  15. 15. Vaccination for 2012 and 2013 West EurAsia FMD
  16. 16. Vaccination Policy Used for Spring Vaccination campaignMap Distribution for Spring Vaccination Campaign Ring vaccination in protection and surveillance zone of outbreaks Provinces implemented vaccination campaign West EurAsia FMD
  17. 17. Vaccination campaign for Autumn 2012 Provinces vaccinated with Trivalent vaccine by campaign Ring vaccination was implement, response to the outbreak in remained (white color) area West EurAsia FMD
  18. 18. Vaccine used for 2012 Sring vaccination campaign Campaign vaccination: 1,985 million doses Trivalent vaccine Ring vaccination: 2.3 million doses trivalent vaccine Thrace Region: 450.000 doses trivalent vaccine In Total: 4,735 million doses; plus private vaccine Vaccination Coverage achieved: 97% in Thrace; 76% in Anatolia where vaccination applied Vaccine used for 2012 Autumn vaccination campaign Campaign vaccination: 5.096.250 doses Trivalent vaccine Ring vaccination: 248.750 doses trivalent vaccine Thrace Region: 750.000 doses trivalent vaccine In Total: 6,095 million doses; plus private vaccine Vaccination Coverage achieved: 98% in Thrace; 79% in Anatolia where vaccination applied West EurAsia FMD
  19. 19. Regions included vaccination and allocated vaccine for Spring 2013 CampaignRegions have been included in Spring vaccination campaign in Turkey according to riskassessment: • Campaign vaccination in Spring2013 : – Eagan (except Muğla), – Marmara and Thrace regions – Inner Anatolia (except three provinces; Aksaray, Karaman and Niğde) – West and Middle Blacksea (Except four provinces; Zonguldak, Bartın, Karabük and Sinop) – Two provinces in Mediterranean ; Burdur and Isparta) – Two provinces in East Anatolia, Malatya and Elazığ • Specific vaccination policy to response type A outbreaks using monovalent type A vaccine Extended ring vaccination has been used for type A outbreak- according to risk assessment all population in district in which occurred outbreak: It has been already initiated since January 2013 • Ring vaccination to reponse outbreak for serotype O and Asia, has been used In remained area of Turkey, – when occurrence outbreak, livestock in protected and surveillance zone of outbreaks will be vaccinated as ring vaccination concept.• ONLY LARGE RUMINANTS HAS BEEN INCLUDED FOR CAMPAIGNALLOCATED AMOUNT OF VACCINE-Campaign vaccination: 5 million trivalent (O Tur07, A Tur06 and Asia1Tur11)-Specific type A monovalent vaccination: 1 million-Ring vaccination: 400.000 trivalent West EurAsia FMD
  20. 20. Map Distribution to be implemented Spring2013 Vaccination Campaign LR vaccination as campaign Ring vaccination to rensponse outbreaks * In all area, specific extended ring vaccination to type A outbreaks bymonovalent vaccine West EurAsia FMD
  21. 21. Critical assessment on if strategy is achieving the goal – Are control measures reducing FMD impact?Yes; Serosurveillance results indicated that where control measures has been applied better, the disease impact has been reduced It was observed that the number of outbreaks and affected animals were sharply decreased after vaccination applied; for example, Asia-1 outbreaks occurred severely in West area of Turkey in Spring 2012 Low incidence was detected in area which biosecurity and other control measures was implemented much more better – Are control measures moving towards FMD elimination? No, it has been not found any indication yet.
  22. 22. Plans related to FMD surveillance and control in the short and long term.Short term Plan for Surveillance and Control• Passive surveillance program will be continued including outbreak investigation and typing as in routine• Ear-tag system will be replaced with barcode system for LR and SR• New sensitive surveillance system has been launched in Thrace, activities will be started afterward this monthLongterm Plan for Surveillance and Control• In framework of National Veterinary Strategy Plan, a study for socio- economic impact of FMD will be carried out in 2014• As requirement of Directive “Standard of Storage, Delivery and Marketing for Veterinary Medicine, Biological Substance and Vaccine”, some work plan has been initiated: – 2D Barcode System for veterinary medicine and vaccine will be implemented – A vaccine storage rooms based on standard will be constructed in eac provincial directorate

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