Anti inflammatory drugs flashcards
Upcoming SlideShare
Loading in...5
×
 

Anti inflammatory drugs flashcards

on

  • 413 views

 

Statistics

Views

Total Views
413
Views on SlideShare
338
Embed Views
75

Actions

Likes
0
Downloads
10
Comments
0

1 Embed 75

http://coldsoretreatment.biz 75

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Anti inflammatory drugs flashcards Anti inflammatory drugs flashcards Presentation Transcript

  • ANTI – INFLAMMATORY DRUGS
  • NSAIDS  Salicyclates  Aspirin  Mesalamine  Sodium-salicyclate  Propionic Acid Derivatives  Ibuprofen  Ketoprofen  Naproxen  Acetic Acid Derivatives  Diclofenac  Ketorolac  Oxicams  Piroxicam  Meloxicam  Indole Derivatives  Indomethacin  Selective COX-2 Inhibitors  Celecoxib
  • Analgesic-Antipyretic Drugs Anti-Inflammatory Steroids  Acetaminophen  Beclomethasone  Betamethasone  Budesonide  Cortisone  Dexamethasone  Hydrocortisone  Prednisone  Triamcinolone
  • NSAIDS  MoA: reversible, competitive inhibition of COX  Irreversible inactivation by Aspirin  Most block COX-1 and -2  Celecoxib is COX-2 inhibitor  Inhibit synthesis of PGs but NOT leukotrienes  Indomethacin is extremely potent  Reduce elevated temperature due to PGE1 & PGE2  Analgesic and antipyretic effects do not undergo tolerance  Toxicity: Acute renal failure & Nephrotic syndrome
  • Agents Effect NSAID Block Effect PGE2, PGI2, PGD2 Enhance early stages of inflammation Anti-inflammatory PGE2, PGI2 Pain receptors in peripherals Peripheral analgesic effect PGE1, PGE2 Increase body temp set Antipyretic point
  • SALICYCLATES  RS: moderate/high doses stimulate; toxic dose     depresses US: high doses cause inhibition of uric acid reabsorption, decrease GFR  hypovolemia  acute renal failure; chronic doses can cause renal lesions Hematopoietic: low/moderate = decreased platelet aggregation (decrease TXA2, increase PGI2); high dose = sideropenia (iron deficiency) Uses: general analgesic, Ulcerative colitis and Crohns’ disease (mesalamine & olsalazine), Thromboemolic disease prophylaxis Toxicity: 1% hypersensitivity, 15% adverse effects (heartburn, nausea, fecal blood loss, gastric bleeding, tinnitus, deafness, vertigo), toxicity in pregnancy, Reye’s syndrome in children, Analgesic nephropathy
  • Non-Salicyclate NSAIDS  All effects similar to salicyclates  Greatest analgesic agent efficacy: Ketorolac  Greatest anti-inflammatory: Indomethacin, Piroxicam, Diclofenac  MoA: COX-1 inhibition: indomethacin, piroxicam  COX-2 inhibition: celecoxib, meloxicam  COX-1 and 2 inhibitors: ibuprofen, naproxen, diclofenac
  • Non-Salicyclate NSAIDS  Propionic Acid Derivatives  MoA: reversible competitive inhibition of COX  Acetic Acid Derivates  MoA: reversible competitive inhibition of COX and decrease in oxygen radicals  Diclofenac: ankylosing spondylitis, eye inflammation, chronic tx of Rheumatoid Arthritis  Ketorolac: analgesic agent, 60% excreted by kidneys  renal damage  Oxicams  MoA: piroxicam is potent reversible COX-1 inhibition; meloxicam for COX-2  Piroxicam has 100% oral bio and ~50 hr half life
  • Indomethacin  Powerful COX-1 inhibitor  Also inhibits:  PLA2  PMN cell migration  T-Cell and B-Cell proliferation  Everything else is same as other NSAIDS  Can’t be used as antipyretic or analgesic agent due to toxicity  Uses: Barter’s syndrome, PDA, nephrogenic diabetes insipidus
  • Analgesic-Antipyretic Drugs  Acetaminophen  95% biotransformed in liver  Small amount toxic metabolite formed  NAPQI  hepatotoxicity  Potent COX inhibitor in CNS; weak in inflamed tissues
  • Anti-Inflammatory Steroids  Glucocorticoids  MoA:  Alters #, distribution, function of peripheral      macrophages; decreases leukocytes, macros, cyto, etc Inhibition of PG and LT synthesis Decrease postcapillary permeability Inhibits effects of complement system Strong inhibitors of cellular immunity Weak inhibitors of humoral immunity  Diagnostic use:  Dexamethasone suppression test used for differential diagnosis of Cushing’s Syndrome
  • RELATED PRODUCTS If you enjoyed this presentation, please take a look at the rest of our products. Our website has many more FREE excellent presentations and tons of other FREE information. HIGHSCORE: Must Know Pharmacology Description: This is a book of 400+ flashcards covering 20 highly tested, and high-yield topics in pharmacology. It is designed so that you can use it anywhere on any device or print it out and use as flashcards. Get the eBook: HERE! Our site: Exam Masters Tutoring Service
  • RELATED PRODUCTS HIGHSCORE: Comparisons of High Yield Topics for the Medical Boards Description: This book contains over 100 comparisons of some of the most highly tested diseases and topics on the USMLE Step 2 CK. The questions on the exam are much more vague than what you see in the practice question banks and it is very difficult to differentiate between two diseases with similar symptoms. So this book is designed to help students improve their score by targeting these types of difficult questions. Get the Free Sample: HERE! Get the whole eBook: HERE!
  • RELATED PRODUCTS USMLE STEP 2 CK TIDBITS & TIPS MONTHLY SUBSCRIPTION Join hundreds of other students preparing for the USMLE Step 2 CK on our USMLE Step 2 CK Tidbits & Tips newsletter! It is an amazing newsletter with tons of great info. The monthly subscription entails a weekly newsletter with info such as high yield disease comparisons, most commonly tested facts, treatments & management, and much more! View a sample Newsletter: HERE! Subscribe to this awesome Newsletter: HERE!