EuroBioForum 2013 - Day 1 | Karin Effertz

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EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013

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# NATIONAL PERSPECTIVES #

Germany:
Personalized Medicine at the German Federal Ministry of Education and Research (BMBF)

Karin Effertz
Scientific Officer at Federal Ministry for Education and Research


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http://www.eurobioforum.eu

Published in: Health & Medicine, Technology
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EuroBioForum 2013 - Day 1 | Karin Effertz

  1. 1. Personalized Medicine at theGerman Federal Ministry of Education and Research (BMBF)• Future Project of the High Tech Strategy 2020 of the BMBF (2010)• Action Field of the Health Research Framework Programm (2010)• Action Plan for Personalized Medicine (2013)• International Strategic Activities of the BMBF in Personalized MedicineDr. Karin Effertz, Personalized Medicine at the BMBF, Eurobioforum Munich 2013
  2. 2. The Action Plan for Personalized Medicine:A new Way for Research and CareDefinition (Excerpt, BMBF)• Personalized Medicine identifies biological factors that influence theprobalbility to develop a disease, its progression and healing as well as theeffectiveness of therapies in a specific, and thereby unique, manner atthe level of the individual patient.• Successes are expected primarily for stratification strategies• Better understanding of the function of factors and their complexinteractions opens options for custom- tailored prevention strategies andtherapies, to reduce side effects and thereby to more effiecienttherapeutic regimenDr. Karin Effertz, Personalized Medicine at the BMBF, Eurobioforum Munich 2013
  3. 3. The Action Plan for Personalized Medicine:A new Way for Research and Care• Perspective: A more in-depth understanding of health and diseasepromises better healing success rates– Patients: Custom-tailored therapies for a more specified care– Health Care System: Efficient and sustainable use of ressources– Health Economy: Promotion of new products and procedures– Society: Increased awareness of health relevant actionsDr. Karin Effertz, Personalized Medicine atthe BMBF, Eurobioforum Munich 2013
  4. 4. Programm: Foci of BMBF Funding• Aims of funding– Better runderstandíng of individual factors that impact disease development andprogression– Clinical validation of results and development of new therapies and products– Lowering of barriers between research/clinics/industryStrategiesFunding of basic and applied biomedical researchSpecial focus on systems medicinebiomarker validationdesign of clinical studiespartnering between academia, clinics and companiesinternational cooperationethical aspects in personalized medicineDr. Karin Effertz, Personalized Medicine at the BMBF, Eurobioforum Munich 2013
  5. 5. The Action Plan for Personalized Medicine:A new Way for Research and Care• If PM is successful, we expect…– Faster and more precise diagnostics (biomarker–based) as well as more efficienttreatments with less side effects– Ineffective therapies to be avoided– Better (interactive) integration of diagnostics and therapy as well as integration of datafrom research and clinics– More investments in individualized medicine in the health economy– Better under standing within the whole society for individualized medicine (FORSA-survey)– Faster market access for products and services related to personalized medicineDr. Karin Effertz, Personalized Medicine at the BMBF, Eurobioforum Munich 2013
  6. 6. Programm: Foci of BMBF Funding• Measures– Identification: better understanding of diseases– Validation and Implementation: Verficaction of results and translationto clinical practice and transfer to the health economy– Discussion: Analysis of consequences for society as a whole– Budget: up to 100 Mio. € from 2013-2016Dr. Karin Effertz, „Personalized Medicine at the BMBF“, Eurobioforum Munich 2013
  7. 7. The Action Plan for Personalized Medicine:A new Way for Research and Care• Launched end of April 2014 by Minister Prof. Wanka together with 3 calls:1) Innovations for Personalized Medicine:• Funding of projects, that aim at the development of new products and processes fordiognosis and therapy considering biomarker- based stratification• Modules: diagnostics and therapy• 3 Phases: Forum for innovations, preparatory phase, realisation phase2) Demonstrators for Personalized Medicine:• Showcases,that demonstrate immediate usefulness and applicability of resultsfrom basic biomedical research for PM.• Use of systems-medicine approaches for prevention, diagnosis and therapy of diseases• A special focus is on data analysis and integration as well as modelling.•3) Ethical, social and regulatory aspects in Systems Medicine• Budget: Up to 100 Mio. € for 3 yearsDr. Karin Effertz, Personalized Medicine atthe BMBF, Eurobioforum Munich 2013
  8. 8. Measures:Better understanding of diseasesThe research and funding concept e:Med• „Paving the way for Systems Medicine“• Systems Medicine uses systems approaches in research and care toilluminate complex physiological and pathological processes and therby tocreate a basis for innovative therapies and preventve measures• 5 Modules1) Research Consortia for Systems Medicine (call closed, 11 Consortia)2) Demonstrators for Individualized Medicine (Call open till August)3) Young Researchers (in preparation)4) Future and Crosscutting Fields5) InternationalizationDr. Karin Effertz, Personalized Medicine atthe BMBF, Eurobioforum Munich 2013
  9. 9. International Activities in Personalized Medicine• CSA Systems Medicine „CASyM“– Objective: Complementing and Coordination of Systems Medicineacross Europe, Strategy paper on Systems medicine. The road mapis driven by clinical needs: It aims to identify areas where a systemsapproach will address clinical questions and solve clinicalproblems.• Key components of this strategy are:• Engagement of all relevant stakeholders• Development of multidisciplinary training concepts• Assessment of methodological and technological challenges• Strengthening innovation activities• Professional dissemination concepts• Analysis of instruments for the implementation of research programs• Creating and shaping a sustainable European community of Systems Medicine• Coordinating Systems Medicine across Europe– Team: 22 partners, scientists, funders– Time: 2012-2016Dr. Karin Effertz, Personalized Medicine atthe BMBF, Eurobioforum Munich 2013
  10. 10. International Activities in Personalized Medicine• CSA PerMed (Idea was born at the Eurobioforum 2012 inBrussels)• Objective:.• overcoming barriers for innovation, such as fragmented activities, lack of communication orgeneric solutions in different fields of PM.• Need governance strategies at the European and global level are to be developed as PMchallenges the way in which healthcare systems worldwide are set up.• A plethora of initiatives already exist (European Science Foundation (ESF) Forward• Look, the Manifesto of the European Alliance for Personalised Medicine (EAPM), the European BestPractice Guidelines of the Public Health Genomics European Network (PHGEN), the Roche report onPersonalized Medicine or the report of the European Hospital and Healthcare Federation (HOPE))• Umbrella Initiative of European and national decision-makers and funding bodiesTeam: 18 international partners from funding bodies, ministries,universitiesTime: Start planned in 2013Dr. Karin Effertz, Personalized Medicine at the BMBF, Eurobioforum Munich 2013
  11. 11. • Priorities for PMIdentification: Better understanding of disease, better biomarker (signatures),integration of BiG DATADiscussion: More responsibility for the individual?Health Care System: Data management vs. Data protection–Dr. Karin Effertz, Personalized Medicine atthe BMBF, Eurobioforum Munich 2013

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