Allergy And Ginseng Case Study

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Ginsengcare.com in Toronto promotes health and wealth for refined ginseng powder

Ginsengcare.com in Toronto promotes health and wealth for refined ginseng powder

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  • 1. Allergy and Ginseng: Research Case Study Eugene Fung www.ginsengcare.com
  • 2. Ginseng : Anti-allergic and anti-inflammatory activities
    • Ginsenoside Rh1 possesses anti-allergic and anti-inflammatory activities.
    • Park EK , Choo MK , Han MJ , Kim DH .
    • College of Pharmacy, Kyung Hee University, Seoul, Korea.
  • 3. BACKGROUND of the Study
    • Ginseng (the root of Panax ginseng C.A. Meyer) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions.
    • In this study, we investigated the anti-allergic activity of ginsenosides isolated from ginseng.
  • 4. METHOD of the Study
    • We isolated ginsenosides by silica gel column chromatography and examined their in vitro and in vivo anti-allergic effect on rat peritoneal mast cells and on IgE-induced passive cutaneous anaphylaxis (PCA) in mice.
    • The in vitro anti-inflammatory activity of ginsenoside Rh1 (Rh1) in RAW264.7 cells was investigated.
  • 5. RESULTS of the Study
    • Rh1 potently inhibited histamine release from rat peritoneal mast cells and the IgE-mediated PCA reaction in mice.
    • The inhibitory activity of Rh1 (87% inhibition at 25 mg/kg) on the PCA reaction was found to be more potent than that of disodium cromoglycate (31% inhibition at 25 mg/kg);
    • Rh1 was also found to have a membrane-stabilizing action as revealed by differential scanning calorimetry.
    • It also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in RAW 264.7 cells, and the activation of the transcription factor, NF-kappaB, in nuclear fractions.
  • 6. CONCLUSION
    • The anti-allergic action of Rh1 may originate from its cell membrane-stabilizing and anti-inflammatory activities.
    • Therefore, Ginsenoside Rh1 can improve the inflammation caused by allergies.
    • http://www.ncbi.nlm.nih.gov/pubmed/14739579