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cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
cBio Cancer Genomics Portal:  Network View
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cBio Cancer Genomics Portal: Network View

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  • 1. cBio Cancer Genomics PortalTutorial: The Network View- Genes in context of biological interactions- Genomic profiles overlaid on interaction network- Filtering by genes of interest, interaction type & source, and genomic profile- Automatic network layout- Exporting as an image
  • 2. Genes in context of biological interactions Seed (specified) genes InteractionsOthers link seeds throughinteractions complied inPathway Commons
  • 3. Genomic profiles overlaid on interaction network White to red color gradient for frequency of total alterationGenomicprofile data(mutation,copy numberand mRNAexpressionprofiles)
  • 4. Filtering by genes of interest Hide selected genes from the network Search genes by name Select genes from canvas or gene list under Genes tab
  • 5. Filtering by interaction type & source Interactions merged by default Type (color-coded) & source shown in interaction details Shown individually
  • 6. Filtering by interaction type & source Partial RB pathway with GBM genomic profile data.
  • 7. Filtering by interaction type & source Same pathway after filtering applied for edge types and sources Uncheck Click
  • 8. Filtering by genomic profile Same pathway after genes with total alteration frequency 12% or less filtered out Slide to threshold value Or typeTP53 threshold valuepathway
  • 9. Automatic network layout Open Layout Options DialogRecalculatelayoutRecalculatelayout uponfiltering Hover over optionoperations to get quick help
  • 10. Exporting as an image Save current network view as PNG image
  • 11. Questions?Send us an email at:cancergenomics@cbio.mskcc.org

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