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Expo ingles Expo ingles Presentation Transcript

  • APPLICATION OF BIOCHEMESTRY TO PHYSIOLOGY INTEGRANTS :GROUP :  CARRION ARCELA JEAN PIERRE 01  CASTRO MALDONADO BETTY  GASCO ARTEAGA LESLIE  GONZALES VASQUEZ DEYSI  MENDOZA CASTILLO FABRIZIO  MORENO VASQUEZ LUIGUI
  • INTRODUCCION It BIOCHEMISTRY is a science that studies the chemical composition of living organisms, especially proteins, carbohydrates, lipids and nucleic acids, as well as other small molecules present in the cells and chemical reactions with these compounds (metabolism) enabling them to obtain energy (catabolism) and generate own biomolecules (anabolism).
  • THROUGH TECHNIQUES AND METHODS PHYSICAL, CHEMICAL AND BIOLOGICAL. THE OBJECT D IS THE SCIENCE EESTUDIO D ELA THAT STUDENT BIOCHEMISTRYLOS BEINGS ALIVE ARE SUBSTANCES A LEVEL THAT CONSTITUTE MOLECULAR E, HUMAN BODY. BIOCHEMISTRY
  • GENERED DIVISION OF THE BIOCHEMISTRY STRUCTURAL MOLECULAR METABOLISM: CHEMISTRY GENETICS:COMPONENTS OF ALL OF THE KNOW THELIFE AND THEBIOLOGICAL CHEMICAL HEREDITY ANDRELATIONSHIP WITH REACTIONS VARIATION.THE CHEMICALSTRUCTURE. THAT OCCUR
  • The science that studies the chemicalbasis of life : the molecules thatcomprise cells and tissues , thatcatalyze chemical reactions of cellularmetabolism such as digestion , thephotosynthesis and immunity , amongother things.
  • IMPORTANCE OFBIOCHEMESTRY IN HEALTH ALL OF THE DISEASES HAVE MOLECULAR COMPONENT EXCEPT THE TRAUMÀTICAS. THE MODERN METHODS HAS SETTLED THE BASIS OF MOLECULAR PATHOLOGY.
  • This biochemical techniques todetect bacteria and viruses, beforethe appearance of antibodies,diagnose and prevent birth defects,making chemotherapy treatmentsand monitoring by detecting andamplifying cancer cells, these arejust some of the profits of thebiochemical the Health Sciences.
  • THE FAST AND BIOCHEMISTRY PHYSIOLOGY1. - WHAT HAPPENS WHEN YOU DEPRIVE AN ORGANISMOF CALORIC INTAKE?•Previously, we discuss in brief the metabolism of human body when it receives the normal caloric intake. This contribution is based on the so- called immediate early 3: Carbohydrates (sugars and carbohydrates), lipids (fats) and proteins.2. - WHAT ARE THE BODYS RESERVES?•The first fact we notice is that the body has reserves. Some say these are measured by weight. A man of about 70 kg. and 1.70 m. high, immediate early reservations are:•GLUCOSE: 300 gr. (4 cal / gr.) = 1,200 Kcal. Last 24 hours.•- FAT: 10 to 11 kg. (9 cal / gr.) = 100,000 Kcal. They last longer than 40 days•- PROTEIN: 10.5 kg. (4 Cal / g) = 45,000 Kcal. In the fast eat the own reserves.
  • BIOCHEMISTRY OF THE FAST AND THE ROLE OF HORMONAL PHYSIOLOGY •Depending on whether one or other immediate principle, as the main source of 1 .- WHAT ARE THE energy during fasting, it can be dividedSTAGES OF FASTING? into three distinct phases as detailed below. •The main fuel is glucose and all sugars and carbohydrates. First circulating glucose is consumed and then do the liver FIRST PHASE: glycogen and muscle. In the biochemical process: •1 º. Glucose is stored in liver and muscle. •2 º. Out of there. •The entry of the organism in hypoglycemia marks the second phase of fasting, characterized by the consumption of fat. Hypoglycemia is the same in charge of SECOND PHASE: implementing the mechanisms that direct consumption of fat in this Phase 2 and will act on the hypothalamus, nerve endings, adrenal and pancreas.
  • SECOND PHASE HYPOTHALA MUSSOMATOTROPIC Prevents glucose is LowersOR GROWTH consumed by the cells. TSH insulin.HORMONE (STH): It is hyperglycemic. Its main functions are to Decreases increase the level of blood insulin sugar antilipolytic through gluconeogenesis PANCREAS hormone CORTISOL to suppress the immune considered, system and help the and increases metabolism of fats . glucagon.
  • FAT METABOLISM fasting, adipose tissue triglycerides are catalyzed steadily, releasing fatty acids into plasma. As this Entering the amount exceeds regarding Krebs cycle. the need of the body, a portion of free fatty acids is used as the primary source of heat and power and the other is metabolized in the liver, where those are converted into acetyl- coenzyme A, which in turn can follow three paths: Transform intoBe used for synthesis ofsubstances that are part of the ketone bodies,plasma triglycerides and which are the otherendogenous cholesterol. major source of energy in fasting.
  • FAT METABOLIS M Moreover, in this second phase, the entire body undergoes a process of adaptation to fasting. In this adaptation are given: b) Reduction ofa) Decreased physicalbasal activity. The bodymetabolism: has less weight and less work.-A quick stepmetabolicreduction.-A slow steppreceded by, oraccompanyingweight loss.
  • THIRD PHASE:Will begin to consume theprotein that are essentialfor life.
  • PHYSIOLOGICAL CONSTANTS: ITS CHANGES DURING FASTING Red blood cells Leukocytes Plasma sodiumPLASM Plasma potass A ium Plasma calciu m Magnesium Chlorine Aldosterone
  • BIOCHEMISTRY AND PHYSIOLOGY OF THE ADRENAL CORTEX Mechanism of action of cortisol RegulationTransport of cortisolof steroids secretion ADRENAL CORTEX
  • Pathophysiology of glucocorticoid production Increased gluconeogenesis and insulin resistanceExcess cortisol Increased protein catabolism Increase and redistribution of body fat Increased secretion of acid by the stomach Sodium retention and redistribution of body fluids leading to edema and hypertension
  • GLUCOCORTICOID INSUFFICIENCY • Involve failure of the PRIMARY adrenal glands: Addisons disease • Absence of ACTH, pituitarySECONDARY failure • The absence of CRH,TERTIARY hypothalamic failure
  • Glucocorticoid insufficiency HYPOTENSION HYPONATREMIA AND HYPERKALEMIA HYPERPIGMENTATION WEAKNESS, FATIGUE, ANOREXIA, VOMITING, WEIGHT LOSS
  • REGULATION OFREGULATION OF RENIN ALDOSTERONE: PRODUCTION:1. Sympathetic stimuli • Aldosterone secretion isreaching the dependent on thejuxtaglomerular concentration of angiotensinapparatus II, plasma potassium and ACTH.2. Sodium flow through • The primary regulator is thethe macula densa of the plasma volumedistal tubule3. Transmural pressure