BIOCHEMISTRY• The Biochemistry is a science that studies the chemistry of living organisms, especially proteins, carbohydrates, lipids and nucleic acids, and other small molecules in cells and also the chemical reactions that these compounds (metabolism) allowing perform to obtain energy (catabolism) and generate biomolecules (anabolism).
PHARMACOLOGY• The Pharmacology is a branch of the Biochemistry; this science studies the drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.• Actually the pharmacology has a great impact in medicine as in biochemistry, because the different types of drugs produce different effects in the same person, according with many factors as for example: the wheater and the emotional aspect.
• Any movement of a drug molecule within the body requires passage throughBIOCHEMISTRY biological OF DRUG membranes.ABOSORCIÓN • This affects both the absorption mechanisms as in the distribution or elimination.
There are two mechanisms THROUGHINTERCELLUL Filtration AR CLEFTS THROUGH CELLMEMBRANES
Molecular weight of the drugConcentr Distance ation Filtration betweengradient cells Pressure on either side of the wall
CONCENTRATION GRADIENT MOLECULAR The transportWEIGHT OF THE across cell LIPOSOLUBILITY DRUG membranes DEGREE OF IONIZATION
The distribution is the transport of the medicament for the blood up to the place where he exercises his action.
Dissolved in the plasma. DRUG DISTRIBUTION Joined Inside certainplasmatic cells. proteins
DISPOSAL OF A DRUG• drug and its active and inactivea The excretion study ways to removemetabolites from the body to theoutside.• Routes of excretion: they allcontribute physiologically to expel theliquid and organic substances.• The drugs are excreted in thefollowing ways: mainly by the kidneyafter biliary-enteric by.
The kidney: it is the most important route of excretion of drugs. Its importance in pharmacology decreases when a drug ismetabolized in its entirety, and only eliminated by the kidney inactive metabolites
Biliary excretion: the drug is metabolizedin the liver, biliary system passes, then the intestine and out through the feces.
Pulmonary excretion: some drugsare excreted in the breath, such asalcohol and general anesthetics.