BIOCHEMISTRY
BIOCHEMISTRY• The Biochemistry is a science that studies the  chemistry of living organisms, especially  proteins, carbohy...
PHARMACOLOGY
PHARMACOLOGY• The Pharmacology is a branch of the Biochemistry; this  science studies the drug action. More specifically, ...
• Any movement               of a drug               molecule within               the body requires               passage...
There are two mechanisms  THROUGHINTERCELLUL   Filtration  AR CLEFTS THROUGH   CELLMEMBRANES
Molecular weight             of the drugConcentr                    Distance ation       Filtration     betweengradient   ...
CONCENTRATION                    GRADIENT MOLECULAR                The transportWEIGHT OF THE    across cell     LIPOSOLUB...
 The    distribution is    the transport of the medicament for the blood up to the place where he exercises his action.
Dissolved in             the plasma.                DRUG            DISTRIBUTION  Joined                            Inside...
DISPOSAL OF A DRUG• drug and its active and inactivea  The excretion study ways to removemetabolites from the body to theo...
The kidney: it is the most important route of    excretion of drugs. Its importance in  pharmacology decreases when a drug...
Biliary excretion: the drug is metabolizedin the liver, biliary system passes, then the    intestine and out through the f...
Pulmonary excretion: some drugsare excreted in the breath, such asalcohol and general anesthetics.
Mechanisms of action         Antibiotics
Bacterial wall                    synthesis                    (penicillin)     Folate                            Membrane...
Biochemis..
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Biochemis..

  1. 1. BIOCHEMISTRY
  2. 2. BIOCHEMISTRY• The Biochemistry is a science that studies the chemistry of living organisms, especially proteins, carbohydrates, lipids and nucleic acids, and other small molecules in cells and also the chemical reactions that these compounds (metabolism) allowing perform to obtain energy (catabolism) and generate biomolecules (anabolism).
  3. 3. PHARMACOLOGY
  4. 4. PHARMACOLOGY• The Pharmacology is a branch of the Biochemistry; this science studies the drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.• Actually the pharmacology has a great impact in medicine as in biochemistry, because the different types of drugs produce different effects in the same person, according with many factors as for example: the wheater and the emotional aspect.
  5. 5. • Any movement of a drug molecule within the body requires passage throughBIOCHEMISTRY biological OF DRUG membranes.ABOSORCIÓN • This affects both the absorption mechanisms as in the distribution or elimination.
  6. 6. There are two mechanisms THROUGHINTERCELLUL Filtration AR CLEFTS THROUGH CELLMEMBRANES
  7. 7. Molecular weight of the drugConcentr Distance ation Filtration betweengradient cells Pressure on either side of the wall
  8. 8. CONCENTRATION GRADIENT MOLECULAR The transportWEIGHT OF THE across cell LIPOSOLUBILITY DRUG membranes DEGREE OF IONIZATION
  9. 9.  The distribution is the transport of the medicament for the blood up to the place where he exercises his action.
  10. 10. Dissolved in the plasma. DRUG DISTRIBUTION Joined Inside certainplasmatic cells. proteins
  11. 11. DISPOSAL OF A DRUG• drug and its active and inactivea The excretion study ways to removemetabolites from the body to theoutside.• Routes of excretion: they allcontribute physiologically to expel theliquid and organic substances.• The drugs are excreted in thefollowing ways: mainly by the kidneyafter biliary-enteric by.
  12. 12. The kidney: it is the most important route of excretion of drugs. Its importance in pharmacology decreases when a drug ismetabolized in its entirety, and only eliminated by the kidney inactive metabolites
  13. 13. Biliary excretion: the drug is metabolizedin the liver, biliary system passes, then the intestine and out through the feces.
  14. 14. Pulmonary excretion: some drugsare excreted in the breath, such asalcohol and general anesthetics.
  15. 15. Mechanisms of action Antibiotics
  16. 16. Bacterial wall synthesis (penicillin) Folate Membrane synthesis permeability((sulfonamides) polyenes) Inhibition DNA RNA synthesis polymerase (metronidaz (rifampicin) ole)
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