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Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and
prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure
regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo
bioelectrical and biochemical laboratory analyses; and ii) overall assessment (comfort,
invasiveness, pain, sedation requirement, etc.) of the rectal forceps biopsy procedure from the
patients perspective to assess its feasibility as an outcome measure in clinical trials.