INTRODUCTION Atopic dermatitis (AD) is a common allergic skin disease in both people and dogs The treatment of dogs with AD is complex and lifelong The aim of this study was to evaluate the clinical benefits of topical Spot-On Skin Lipid Complex (SLC) in the treatment of dogs with chronic AD The study took place in Fujimura Animal Allergy Hospital, Japan, from September 2009 to December 2009
METHODS The investigators recruited 8 dogs from their hospital with a diagnosis of chronic AD and persistent pruritus despite therapy. The dogs were treated with SLC topically as adjunct therapy for 12 weeks. A topical SLC product containing ceramides, cholesterol and free fatty acids was applied at a dose of 2 mL twice weekly, by applying several drops on the head, inter scapular area, and directly on lesion sites
RESULTS After 6 weeks of SLC treatment, a substantial improvment in the dogs condition occured It was caused by the reduction in the erythema (36.2%, p<0,005), excoriation (39,9%, p<0,05) and alopecia subscores (19.9%, p<0,05). There were no markable advances in the treatment of lichenification as the decrease rate was statistically unimportant. For the evaluation of the efficency of SLC therapy, the third version of the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) modification was used
Clinicalcharacteristicsof Dog 5 atstart of thetreatment (D0)
The dog wastreatedcontinuously afterthe completion ofthe trial. Clinicalsymptomsimproved 18weeks after D0.
CONCLUSIONS The results of this study suggest that topical SLCapplication is beneficial when used in the management ofcanine AD. Topical lipid applications are not effective as monotherapy but as an adjunct therapy they may bring new hope in the treatment of canine AD Although the findings are encouraging, double-blinded placebo-controlled or cross-over studies are needed to confirm the results. The drug-sparing effects of SLC applications also deserve further investigation
REFRENCES“Spot-On Skin Lipid Complex as an Adjunct Therapyin Dogs with Atopic Dermatitis: An Open Pilot Study“Masato Fujimura, Yoshinobu Nakatsuji, SubaruFujiwara, Christophe Rème and Hugues GattoVeterinary Medicine International, Volume 2011http://www.hindawi.com/journals/vmi/2011/281846/