ECCLU 2011 - C. Bosetti - Epidemiology in Europe

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ECCLU 2011 - C. Bosetti - Epidemiology in Europe

  1. 1. Epidemiology of Genito-Urinary Cancers in Europe Cristina Bosetti Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri" Milan, Italy ECCLU- 12 May 2011 - Lugano, Switzerland
  2. 2. Mortality trends in Europe (1970-2007) <ul><li>Prostate </li></ul><ul><li>Testis </li></ul><ul><li>Bladder </li></ul><ul><li>Kidney/other urinary tract </li></ul>
  3. 3. Mortality trends in Europe (1970-2007) <ul><li>Prostate </li></ul><ul><li>Testis </li></ul><ul><li>Bladder </li></ul><ul><li>Kidney/other urinary tract </li></ul>Official death certification data from the WHO database. Age-standardized (world population) rates per 100,000 at all ages, and truncated at age 35-64 years.
  4. 4. Prostate cancer mortality: EU 27
  5. 5. <ul><li>In the EU as a whole, overall prostate cancer mortality reached a peak in 1995 at 15.0/100,000 men, and declined to 12.5/100,000 in 2006 , with a reduction of -3.8% per year over more recent years. </li></ul>Prostate cancer mortality: EU 27
  6. 6. Prostate cancer mortality
  7. 7. Prostate cancer mortality: Eastern Europe
  8. 8. Prostate cancer mortality
  9. 9. <ul><li>Improvements in the management and treatment have played a relevant role on the favorable trends in prostate cancer mortality, while it is not possible to quantify the potential impact of PSA and (opportunistic) screening. </li></ul>Prostate cancer mortality
  10. 10. Testicular cancer mortality: EU 27
  11. 11. <ul><li>In the EU overall, rates declined from 0.75 in 1980 to 0.32/100,000 in 2006 . Overall rates declined by 4% per year between 1980 and 1999, whereas afterward there was a leveling off in rates, particularly in middle-age men. </li></ul>Testicular cancer mortality: EU 27
  12. 12. Testicular cancer mortality
  13. 13. Testicular cancer mortality
  14. 14. <ul><li>Advancement in treatments have largely contributed to the favorable testicular cancer mortality trends over the last decades, although in most central/eastern Europe there is still a substantial delay in adequate treatment for this neoplasm. </li></ul>Testicular cancer mortality
  15. 15. Bladder cancer mortality - EU 27
  16. 16. <ul><li>In the EU as a whole, overall bladder cancer mortality was stable till the early 1990’s, and declined thereafter, particularly in men, from 7.3 in 1992 to 5.5/100,000 in 2006 ; in EU women, rates declined from 1.5 to 1.2/100,000 . </li></ul>Bladder cancer mortality - EU 27
  17. 17. Bladder cancer mortality: Eastern Europe
  18. 18. Bladder cancer mortality
  19. 19. <ul><li>The control of tobacco and occupational exposures (aromatic amines) has contributed to declines in bladder cancer mortality in men from most Europe. </li></ul>Bladder cancer mortality
  20. 20. Kidney cancer mortality: EU 27
  21. 21. <ul><li>Mortality from kidney and other urinary sites cancer has increased throughout Europe until the early 1990’s, but leveled off thereafter between 1994 and 2006 , in EU men rates declined from 4.9 to 4.3/100,000 . </li></ul><ul><li>In EU women, corresponding falls were from 2.1 to 1.8/100,000 . </li></ul>Kidney cancer mortality: EU 27
  22. 22. Kidney cancer mortality: Eastern Europe
  23. 23. Kidney cancer mortality: Eastern Europe
  24. 24. Kidney cancer mortality
  25. 25. <ul><li>The declines in kidney cancer is partly attributable to the reduced prevalence of smoking in men , though the increased prevalence of overweight and obesity may have had some unfavorable effect on kidney cancer rates. </li></ul>Kidney cancer mortality
  26. 26. <ul><li>Trends in urologic cancer mortality were favorable over the last 2 decades in most Europe, with the exception of a few central/eastern countries, where some leveling off in rates started only more recently. </li></ul>Conclusion
  27. 27. Thank you for your attention! [Eur Urol. 2011 Apr 5. [Epub ahead of print] PMID: 21497988] For further details…
  28. 28. Prostate cancer mortality
  29. 29. Testicular cancer mortality
  30. 30. Bladder cancer mortality
  31. 31. Kidney cancer mortality

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