Sleeve, Band, RNY and the Mini-Gastric Bypass
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Sleeve, Band, RNY and the Mini-Gastric Bypass

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Safe and Effective Treatment of Obesity & Diabetes: Failure of the Band, Sleeve & RNY vs Success of the Mini-Gastric Bypass ...

Safe and Effective Treatment of Obesity & Diabetes: Failure of the Band, Sleeve & RNY vs Success of the Mini-Gastric Bypass
Medical News: Bypass Surgery for Diabetes w Nonmorbid Obesity? Marlene Busko: Jun 04, 2013
BUT: Not metioned in the abstract:
22 serious complications in 60 RNY patients (36%);
2 most serious complications Anastomotic leaks (3.3%)
1 patient suffered anoxic brain injury.
RNY pts more likely to have Complications

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Sleeve, Band, RNY and the Mini-Gastric Bypass Sleeve, Band, RNY and the Mini-Gastric Bypass Presentation Transcript

  • Safe and Effective Treatment of Obesity & Diabetes: Failure of the Band, Sleeve & RNY vs Success of the Mini-Gastric Bypass
  • Medical News: Bypass Surgery for Diabetes w Nonmorbid Obesity? Marlene Busko: Jun 04, 2013 • "In a new report, RNY bypass in mildly to moderately obese patients with uncontrolled diabetes had better short-term glucose control and weight loss than their peers who received medications and lifestyle advice." • JAMA. 2013 Jun 5;309(21):2240-9. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. Ikramuddin S, Korner J, Lee WJ, Connett JE, Inabnet WB, Billington CJ, Thomas AJ, Leslie DB, Chong K, Jeffery RW, Ahmed L, Vella A, Chuang LM, Bessler M, Sarr MG, Swain JM, Laqua P, Jensen MD, Bantle JP. Department of Surgery, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. ikram001@umn.edu
  • Medical News: Bypass Surgery for Diabetes w Nonmorbid Obesity? Marlene Busko: Jun 04, 2013 • BUT: Not metioned in the abstract: • 22 serious complications in 60 RNY patients (36%); • 2 most serious complications Anastomotic leaks (3.3%) • 1 patient suffered anoxic brain injury. • RNY pts more likely to have Complications
  • Obesity surgery-diabetes study shows pros and cons By LINDSEY TANNER | Associated Press – Tue, Jun 4, 2013 • "About a third of the 60 RNY's developed serious problems within a year of the operation" • "That rate is similar to what's been seen in previous studies of RNY Bypass" • "the most serious complications — infections, intestinal blockages and bleeding"
  • Obesity surgery-diabetes study shows pros and cons By LINDSEY TANNER | Associated Press – Tue, Jun 4, 2013 • The most dangerous complication occurred in • one patient when stomach contents leaked, leading to overwhelming infection, leg amputation and brain injury. • Lead author Dr. Ikramuddin called that case "a fluke."
  • Obesity surgery-diabetes study shows pros and cons By LINDSEY TANNER | Associated Press – Tue, Jun 4, 2013 • Although RNY pts lost nearly 60 lbs • Only 75% lowered sugar levels to normal or near normal levels • JAMA editorial says such devastating complications are rare, but that • "the frequency and severity of complications ... is problematic"
  • We Must Ask For Better than: 36% Serious Complications 3% Leak Rate A case of brain damage and Leg Amputation is NOT "a fluke"
  • A CLARION CALL FOR BETTER BARIATRIC SURGERY • RNY and VBG FAIL to cut helathcare costs or Lengthen Life in VA Studies (1) • Bariatric Surgery; A History of Complications & Failure • We Need Better Bariatric Surgery • We Simpler, Safer, More Powerful, More Durable and Revisable and Reversible
  • Primary Objectives • Obesity and Diabetes are Growing Problems in India • Surgery Can Successfully Treat Obesity and diabetes in Both the Thin and Obese Diabetic Patient • The Band, the Sleeve and the RNY are failed forms of Bariatric Surgery • The Mini-Gastric Bypass is Both Very Safe and Very Effective Over the Short and Long Term
  • Obesity and Diabetes are Growing Problems in India
  • India the worlds with largest number of diabetics
  • Obesity and Diabetes are Growing Problems in India
  • Surgery Can Successfully Treat Obesity and Diabetes in Both the Thin and Obese Diabetic Patient
  • Surgery Can Successfully Treat Obesity and Diabetes in Both the Thin and Obese Diabetic Patient • 2011: Lee et al. MGB vs SLEEVE • 12 mos prospective study T2DM patients • Results: • Type 2 Diabetes resolved • 93% MGB
  • RNY Bypass Surgery for Diabetes With Nonmorbid Obesity? Maybe Jun 04, 2013 • 12-months, 28 participants (49%) RNY group and 11 (19%) in the lifestyle-medical management group achieved the primary end points • BUT • 22 (36%) serious complications in the RNY group • 2 most serious complications were anastomotic leak 3.3%!!, • 1 patient suffered anoxic brain injury. • Patients who underwent surgery were also more likely to have nonserious adverse events such as nutritional deficiencies. • JAMA. 2013 Jun 5;309(21):Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. Ikramuddin S, Department of Surgery, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. ikram001@umn.edu
  • Primary Objectives • Obesity and Diabetes are Growing Problems in India • Surgery Can Successfully Treat Obesity and diabetes in Both the Thin and Obese Diabetic Patient • The Band, the Sleeve and the RNY are failed forms of Bariatric Surgery • The Mini-Gastric Bypass is Both Very Safe and Very Effective Over the Short and Long Term
  • The Band, the Sleeve and the RNY are Failed forms of Bariatric Surgery
  • The Mini-Gastric Bypass is Both Very Safe and Very Effective Over the Short and Long Term
  • SUCCESS CRITERIA "IDEAL" WEIGHT LOSS SURGERY SAFETY & EFFICACYSAFETY & EFFICACY
  • SUCCESS CRITERIA "IDEAL" WEIGHT LOSS SURGERY • 1. Low Risk (SAFETY) • 2. Major Weight Loss (EFFICACY) • 3. Easily performed • 4. Short operative times (SAFETY) • 5. Outpatient or short hospital stay (SAFETY) • 6. Minimal Blood Loss (SAFETY) • 7. No Need for ICU Stay (SAFETY) • 8. Minimal Pain • 9. Very High Patient Satisfaction • 10. A Good "Exit Strategy" (SAFETY)
  • SUCCESS CRITERIA "IDEAL" WEIGHT LOSS SURGERY • 11. Change Behavior & Preferences; Marked Decrease in Hunger and Increased Satiety • 12. Minimal Retching and Vomiting • 13. Few adhesions or hernias (SAFETY) • 14. Minimal impact on Heart and Lung Function (SAFETY) • 15. Low Failure Rate (EFFICACY) • 16. Low Cost • 17. Short Recovery Time • 18. Rapid Return to Work • 19. Low Risk of Pulmonary Embolus (SAFETY) • 20. Durable weight loss (EFFICACY)
  • SUCCESS CRITERIA "IDEAL" WEIGHT LOSS SURGERY • 21. Low Risk of Ulcer (SAFETY) • 22. Fat Malabsorption; low cholesterol & CV risk (EFFICACY) • 23. No Plastic Foreign Body (SAFETY) • 24. Easily Verifiable Results; > 10 years of Results (EFFICACY) • 25. Low Risk of Bowel Obstruction (SAFETY) • 26. Based upon sound surgical principles (SAFETY) • 27. Independent confirmation of results (EFFICACY) • 28. Healthy life after surgery (SAFETY) • 29. Supported by LEVEL I Evidence; RCT (Controlled Prospective Randomized Trial) (EFFICACY) • 30. Block “Sweet Eater” Failures (EFFICACY)
  • The Band, the Sleeve and the RNY are Failed forms of Bariatric Surgery Published Data Expert Opinion
  • Summary: Band, Sleeve & RNY • In Short: • Band: Now fading = Very Safe/NOT Very Effective at 5 yrs • Sleeve: Popular = Not very Safe/Fading Effectiveness • RNY: By Every Measure Most Dangerous Bariatric Surgery & Effectiveness "Issues"
  • Failed Lap Band
  • Failed Lap Band
  • Sleeve Leak
  • RNY Bypass Surgery for Diabetes With Nonmorbid Obesity? Maybe Jun 04, 2013 • After 12-months, 28 participants (49%) in the gastric bypass group and 11 (19%) in the lifestyle-medical management group achieved the primary end points • BUT • 37% serious complications in the RNY group • 2 most serious complications were anastomotic leak 3.3%!!, • 1 patient suffered anoxic brain injury. • Patients who underwent surgery were also more likely to have nonserious adverse events such as nutritional deficiencies. • JAMA. 2013 Jun 5;309(21):Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. Ikramuddin S, Department of Surgery, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. ikram001@umn.edu
  • RNY Leak
  • 28,000 Patients • Ann Surg. 2011 Sep;254(3):410-20 First report from the American College of Surgeons Bariatric Surgery Center Network 28,000 Patients Hutter MM, Schirmer BD, Jones DB, Ko CY, Cohen ME, Merkow RP, Nguyen NT. Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA. mhutter@partners.org
  • Band Sleeve RNY
  • Band Sleeve RNY
  • Band Sleeve RNY
  • Published Data: ACS Study 28,000 pts: Conclusions • Lap Band: Very Safe but 5 year Failure • Sleeve: More Dangerous than Band and following Band's track to 5 yr failure • RNY: More effective but studies clearly show long term weight regain and recurrence of Diabetes • RNY: Clearly the most dangerous Bariatric Surgery (Remember 36% serious complications and 3.3% Leak rate)
  • In Short: Published Data: ACS Study 28,000 pts: Conclusions • Lap Band: Safe but Fails • Sleeve: Danger >> Band + 5 yr failure • RNY; More effective but Most dangerous • Needed: Safety and Effectiveness • Mini-Gastric Bypass
  • Sleeve Gastrectomy Failure: • Sleeve gastrectomy and the risk of leak: a systematic analysis of 4,888 patients. • “Risk of leak is low at 2.4%." !! • Surg Endosc. 2012 Jun;26(6):1509-15. Epub 2011 Dec 17. Aurora AR, Khaitan L, Saber AA. Department of Surgery, University Hospitals Case Medical Center, Cleveland, Ohio
  • What do the Experts Say?
  • Survey Results • As part of a Pre-Conference survey for the • MGB/OAB Consensus Conference • Asked Expert Surgeons to Judge 4 weight loss procedures. • This is a report Expert Judgment of the Band, the Sleeve, RNY and the MGB
  • 12. Your Opinion about the LAP BAND • LAP BAND is good, short simple surgery, maybe the best form of WLS, I use it often 7.1% • LAP BAND is OK it is an acceptable alternative and I use it sometimes 46.4% • LAP BAND is a Bad operation and should not be used 46.4%
  • Frequency of Negative Judgment
  • Frequency of Choice as "Best" form of Surgery
  • Failed Sleeve Converted to RNY; Sept 2012 Less 24 months! • Failed Sleeve: • Weight loss • Diabetes Rx • SEVERE Reflux symptoms. • Time to Failure less than 24 months. • 30% for "Severe Reflux"!!!! • Indications and Mid-Term Results of Conversion from Sleeve Gastrectomy to Roux- en-Y Gastric Bypass. Authors Gautier T, et al. Obes Surg. 2012 Sep 23. Département de Chirurgie Digestive, Caen University Hospital, Caen Cedex, France, gautier.tho@gmail.com.
  • Why the Band and Sleeve Fail Restrictive Procedures and Sweet and "Liquid Calories"
  • Band, Sleeve vs the Neuro-Humoral Drive to Eat • Restrictive Procedures • MAKE SWEET EATERS: • Mechanical Block of Normal Healthy Foods • Weight Loss: Honeymoon 2 years • Then Failure Weight Regain • GE Reflux (Risk of Esophageal Cancer)
  • Band & Sleeve Block Normal Healthy Foods • Weight Loss => • Increased Hunger • Decreased Satiety • Healthy Foods Blocked • Drive to Eat UP • What Happens?
  • Band & Sleeve; Block Intake Normal Healthy Food Sleeve Band
  • Restrictive Procedures • Successfully Block Normal Healthy Diet But • They DO NOT BLOCK ...
  • Pathologic Dietary Choices Calories: Ice Cream 200g/540 cal, 2 Milky-way Bars, 1,000 cal 2 L Bottle Coke 830 cal Total: 2,370 cal
  • Diet Induced Increased Hunger
  • Summary • Most Diets & Restrictive Procedures (Band/Sleeve) Will Fail • Attempts to Override Neuro-Humoral Hunger System Routinly Fails • R.P.s Force Patients into Pathological Dietary Choices • MAKE SWEET EATERS!
  • Primary Objectives • Obesity and Diabetes are Growing Problems in India • Surgery Can Successfully Treat Obesity and diabetes in Both the Thin and Obese Diabetic Patient • The Band, the Sleeve and the RNY are failed forms of Bariatric Surgery • The Mini-Gastric Bypass is Both Very Safe and Very Effective Over the Short and Long Term
  • SOLUTION?
  • Diet Induced Increased Hunger
  • Mini-Gastric Bypass The Mongoose!
  • Mini-Gastric Bypass • Blocks Neuro-Humoral Hunger System • Short, Simple, Durable, 30 minute Surgery that: • Decreases Hunger & Increases Satiety The Mongoose He is a Little Bit Ugly, No?
  • Mini-Gastric Bypass: 2 Steps Step 1: Gastric Tube; Step 2: Bypass
  • Step 1: Creation of Gastric Tube
  • Step 2: Billroth II Gastro-Jejunostomy
  • One Thousand Consecutive Mini-gastric Bypass: Short- And Long-term Outcome (Noun) • 1,000 patients who underwent MGB • Operative time and length of stay for MGB • 89 min • 1.8 days • Short-term complications 2.7% • Obes Surg. 2012 May;22(5):697-703. One thousand consecutive mini-gastric bypass: short- and long-term outcome. Noun et al, Department of Digestive Surgery, Hôtel-Dieu de France Hospital and University Saint Joseph Medical School, Naccache, Achrafieh, BP 166830 Beirut, Lebanon. rnoun@wise.net.lb
  • One Thousand Consecutive Mini-gastric Bypass: Short- And Long-term Outcome (Noun) • 0.5% Leaks • Four (0.4%) patients, severe bile reflux Rx by stapled latero-lateral jejunojejunostomy (Braun). • Excessive weight loss occurred in four patients easily revised. • Percent excess weight loss (EWL) of 73% occurred at 18 months • Obes Surg. 2012 May;22(5):697-703. One thousand consecutive mini-gastric bypass: short- and long-term outcome. Noun et al, Department of Digestive Surgery, Hôtel-Dieu de France Hospital and University Saint Joseph Medical School, Naccache, Achrafieh, BP 166830 Beirut, Lebanon. rnoun@wise.net.lb
  • 9 Year MGB Follow Up Efficacy & Safety • Excess weight loss and mean BMI 5 years after LMGB was 72.1% and 27.1 • Of the 1322 patients, 23 (1.7%) reop surgery during a follow-up of 9 years. • The most common cause of revision was excess wt loss in 9, followed by inadequate weight loss in 8, and bile reflux in 3. • No internal hernia or ileus during the follow-up period. • Conclusion: MGB Excellent Durable Long Term Safe (No Hernia/Bowel Obstruction) • Surg Obes Relat Dis. 2011 Jul-Aug;7(4):486-91.Revisional surgery for laparoscopic minigastric bypass. Lee WJ, Department of Surgery, Min-Sheng General Hospital, National Taiwan University, Taipei, Taiwan. wjlee_obessurg_tw@yahoo.com.tw
  • 6436 CONSECUTIVE MINI- GASTRIC BYPASSES: 16 YEARS LATER Robert RUTLEDGE1 1Director, Surgery, Center For Laparoscopic Obesity Surgery, United States of America
  • Rutledge Results • Mean preoperative weight 151 +/- 31 kg, BMI 46 +/- 7. & • 79% were female. • Mean operative time 43 + 11 min • Median length of stay 1 day. • Three deaths occurred within 30 days of surgery, (0.05%). • None in the last 10 years.
  • Rutledge Results • Early complications occurred in 4.9%. • 44 (0.7%) patients had anastomotic leaks. • Three (0.05%) patients presented with dypepsia/bile reflux not responsive to medical therapy and were successfully treated by Braun side-to-side jejuno-jejunostomy. • Gastritis/dyspepsia/marginal ulcer was the most serious long term complication; routinely treated medically.
  • Rutledge Results • Excessive weight loss occurred in 1% of patients; treated by take down of the bypass. • Mean % excess weight loss (EWL) of 78%. • 10 year weight regain 4.9%. • >50% EWL was achieved for 95% of patients at 18 months and for 92% at 60 months. • 6% of patient had inadequate weight loss or significant weight regain were treated by revision, (addition of ~2 meters to the bypass).
  • RNY Doubles the need for hospitalisation • In California from 1995 to 2004, • 60,077 patients underwent RYGB- 11,659 in 2004 alone. • The rate of hospitalization in the year following RYGB was more than double the rate in the year preceding RYGB • (19.3% vs 7.9%, P<.001). • Hospitalization before and after gastric bypass surgery. Zingmond DS, McGory ML, Ko CY. JAMA. 2005 Oct 19;294(15):1918-24.
  • MGB Decreases the Hospitalization After Surgery • The rate of hospitalization after MGB • Declined from 17% to 11% the year after and • 2/3 of these admisions were unrelated to MGB • Hospitalization before and after mini-gastric bypass surgery. Rutledge R. Int J Surg. 2007 Feb;5(1):35-40. Epub 2006 Aug 10
  • 2011: Lee et al. MGB vs SLEEVE • 12 mos prospective study 60 T2DM patients • Matched for DM duration, type of DM treatment, and glycemic control • Results • T2DM resolved 47% SG and 93% GBP (p = 0.02) • Weight loss fasting glucose, Hgba1c waist circumfrence all worse in SG
  • 2011: Lee et al. RYGB vs SLEEVE (Efficacy) • Controlled Prospective Trial: SG is only HALF as effective as MGB in inducing remission of T2DM 50% 90%
  • Mini-Gastric Bypass Decreases Hunger Survey 2,783 Pts
  • What Do the Experts Say? Survey of 102 surgeons answered detailed survey online. Surgeons from 6 Continents and 23 countries. The group reported on a past year's experience with over 39,000 cases, Very experienced surgeons.
  • Over 100 Surgeons from Around the World:
  • Both Kular and Rutledge, Op Time < 40 min
  • Risk of Esophageal Cancer?
  • 30% Reflux & Esophageal Cancer?
  • Leaks Surg Obes Relat Dis. 2008 Jul-Aug;4(4):528-33. Laparoscopic sleeve gastrectomy:
  • Leak Rate • Leak Rate in New Multicenter trial • 3.3%!! • Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. • Ikramuddin S, Korner J, Lee WJ, Connett JE, Inabnet WB, Billington CJ, Thomas AJ, Leslie DB, Chong K, Jeffery RW, Ahmed L, Vella A, Chuang LM, Bessler M, Sarr MG, Swain JM, Laqua P, Jensen MD, Bantle JP. • JAMA. 2013 Jun 5;309(21):2240-9.
  • Expert Opinion In Summary • Restrictive Procedures Fail (Band Sleeve) • Starting at 2-5 Years • Restrictive Procedures Push Patients towards Liquid Calories • (Can a Sleeve stop Coke!)(Can a Sleeve stop Coke!) • Weight Regain is Common • Acid Reflux 30%+ • Acid Reflux = Esophageal Cancer
  • Why is the MGB So Much Better than the Sleeve
  • 2006: Rubino et al. Duodenal exclusion • “This study shows that bypassing Duodenum directly ameliorates type 2 diabetes, • independently of effects on food intake, body weight, malabsorption, or nutrient delivery to the hindgut.” • The Mechanism of Diabetes Control After Gastrointestinal Bypass Surgery Reveals a Role of the Proximal Small Intestine in the Pathophysiology of Type 2 Diabetes. Rubino, Francesco, MD; Forgione, Antonello, MD; Cummings, David E MD; Vix, Michel MD; Gnuli, Donatella MD; Mingrone, Geltrude MD; Castagneto, Marco, MD (S); Marescaux, Jacques MD, FRCS Annals of Surgery; 244 (5): 741-749, November 2006
  • Outcome after gastrectomy in gastric cancer patients with type 2 diabetes • 403 gastric cancer patients with T2DM • BMI % Reduction • Duodenal Bypass: • No Bypass 7.6% • Bypass 11.4% • Jong Won Kim, etal, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea, World J Gastroenterol. 2012 January 7; 18(1): 49–54.
  • Bile Acids: Critical Hormonal Factors in glucose homeostasis • Decrease in the bile acid pool results in decreases in hemoglobin A1c, glucose levels and improved insulin sensitivity. • Duodenal bypass improve the success in the resolution of diabetes. • Combined procedures include duodenal bypass which leads to decrease in bile acid pool.
  • The Mini-Gastric Bypass Excellent Operation with Results Reported on Thousands of Patients Over the Past 10-15 years • Survey Shows: • Short, Simple, Effective, Durable, • 30 min Operation with 1 day Hospital Stay • Lower Leak rate than Sleeve or RNY • Best Weight Loss • Easily Reversible, Revisable
  • Primary Objectives • Obesity and Diabetes are Growing Problems in India • Surgery Can Successfully Treat Obesity and diabetes in Both the Thin and Obese Diabetic Patient • The Band, the Sleeve and the RNY are failed forms of Bariatric Surgery • The Mini-Gastric Bypass is Both Very Safe and Very Effective Over the Short and Long Term
  • Conclusions • Sleeve: popular now; Relatively Dangerous and shows Band's signs of 5 year failure and new onset GERD in 30% • MGB short simple reversible and revisable operation may be up to twice as effective as Sleeve and has excellent long term durability
  • Marginal Ulcer has been known since the beginning GI Surgery  MARGINAL, GASTROJEJUNAL OR PEPTIC ULCER SUBSEQUENT TO GASTROENTEROSTOMY.  Erdmann JF.  Ann Surg. 1921 Apr;73(4):434-40.
  • UNINFORMED FEAR BILLROTH II EDUCATED USE BILLROTH II • 1. Gastric Cancer Declining Rapidly, > 50% • 2. Gastric Cancer Cause: Environmental Factors / Easily Prevented Diet, Lifestyle changes and Rx of H. Pylori (Avoid Etoh, smoking, processed & salted meats and foods, seek high intake of fruits and vegetables)
  • UNINFORMED FEAR BILLROTH II EDUCATED USE BILLROTH II • 3. Some studies Slight Increased Risk of gastric cancer after 20 – 30 years (RR 1.5): But: BII to Rx Ulcer => Ulcer => Increased Risk • (Worried? Rx H Pylori, Eat healthy etc.) • 4. Many Large Studies: No Increased Risk Thousands of patients followed for Decades
  • UNINFORMED FEAR BILLROTH II EDUCATED USE BILLROTH II • 5. Endoscopic screening of Billroth II patients is Not Recommended. Why? Low Risk! • 6. General, Trauma and Oncologic surgeons routinely use the Billroth II (Thousands of publications) • 7. 2007 ~16,000 BII procedures were performed in the USA
  • Marginal Ulcers: Achilles Heel of Gastric Bypass  Management  1. Warn Patients & Surgeon “Be Vigilant”  2. Aggressive anti-H. Pylori Rx  3. Aggressive use of Antacids  4. Strict Avoidance of Ulcerogenic Agents (NSAIDS, Etoh, Smoking, Coffee, Soda, Nitrates)  5. Encourage: Probiotics, Yogurt, Fruits Vegetables  BILE MAKES NO DIFFERENCE!!!