Slides with topics that are covered and were tested in the recent Absite exams. Nir Hus MD., PhD. http://www.nirhus.com

1. Absite topics 13-15
Nir Hus
Nir Hus

2.  The Proper time for prophylactic dosing
is:
A. 1 hr. preop
B. With induction of anasthesia
C. At the time of skin incision
D. 2 hrs preop
Nir Hus

3. Q13 – Infection rate of wounds
Nir Hus

4. ~2%
3%-5%
5%-10%
>30%
Nir Hus

5. Q14 - Drug dose adjust for
Hemodialysis for Low Molecular
Weight Heparin
 For Lovenox, no dose adjustment for H.D.
 For CrCl < 30  DVT proph. 30 mg SQ
daily not 40.
 Normal halflife 4.5-7 hrs.
Nir Hus

6. Q15 - Staphylococcus epidermis
 Eradication of Staphylococcus epidermis
is difficult to achieve due to:
A. Secretion of exotosins
B. Production of exoslime
C. Release of endotoxin
D. Rapid growth rate
Nir Hus

7. Staphylococcus epidermis
 Staphylococcus epidermis exoslime is a polysaccharide
composed of glycosaminoglycans which allows for
strong intercellular adhesion between bacterial cells and
the formation of biofilms.
 The ability to form biofilms allows S. epidermidis to
cause resistant infections particularly when foreign object
are present.
 This is due to inability of antibiotics to penetrate the
mucopolysaccharide of the biofilm.
 The ica operon has been shown to control the production
of slime . The ica genes can be tested for as a
virulence marker.
Nir Hus

8. Q - Respirator Quotient in sepsis
& vent support
 Respirator Quotient (RQ) is the ratio of VCO2
(production) to VO2 (consumption).
 A characteristic RQ exists for each fuel being
metabolized.
 Fat: 0.7
 Protein: 0.8
 Glucose : 1.0
 If RQ is greater than 1, strong indicator of
overfeeding.
Nir Hus