Nir Hus Absite review q5b
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Nir Hus Absite review q5b



Slides with topics that are covered and were tested in the recent Absite exams.

Slides with topics that are covered and were tested in the recent Absite exams.
Nir Hus MD., PhD.



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Nir Hus Absite review q5b Nir Hus Absite review q5b Presentation Transcript

  • Absite topics 13-15 Nir Hus Nir Hus
    • The Proper time for prophylactic dosing is:
    • 1 hr. preop
    • With induction of anasthesia
    • At the time of skin incision
    • 2 hrs preop
    Nir Hus
  • Q13 – Infection rate of wounds Nir Hus
    • ~2%
    • 3%-5%
    • 5%-10%
    • >30%
    Nir Hus
  • Q14 - Drug dose adjust for Hemodialysis for Low Molecular Weight Heparin
    • For Lovenox, no dose adjustment for H.D.
    • For CrCl < 30  DVT proph. 30 mg SQ daily not 40.
    • Normal halflife 4.5-7 hrs.
    Nir Hus
  • Q15 - Staphylococcus epidermis
    • Eradication of Staphylococcus epidermis is difficult to achieve due to:
      • Secretion of exotosins
      • Production of exoslime
      • Release of endotoxin
      • Rapid growth rate
    Nir Hus
  • Staphylococcus epidermis
    • Staphylococcus epidermis exoslime is a polysaccharide composed of glycosaminoglycans which allows for strong intercellular adhesion between bacterial cells and the formation of biofilms.
    • The ability to form biofilms allows S. epidermidis to cause resistant infections particularly when foreign object are present.
    • This is due to inability of antibiotics to penetrate the mucopolysaccharide of the biofilm.
    • The ica operon has been shown to control the production of “slime”. The ica genes can be tested for as a virulence marker.
    Nir Hus
  • Q - Respirator Quotient in sepsis & vent support
    • Respirator Quotient (RQ) is the ratio of VCO 2 (production) to VO 2 (consumption).
    • A characteristic RQ exists for each fuel being metabolized.
    • Fat: 0.7
    • Protein: 0.8
    • Glucose : 1.0
    • If RQ is greater than 1, strong indicator of overfeeding.
    Nir Hus