Differences in the sensitive phase
    of the maturation of the
 auditory and visual pathways
     Dr. Dr. hc. Monika Lehnhardt
         Cernobbio, June 2008
„Direct stimulation of the
auditory nerves with resultant
speech perception is not feasible

M. Lawrence, 1964
“It is a crime to provide deaf
children with a cochlear implant”

German physiologist R. Klinke, 1988
From: “Strabismus und Motilität” Zur Entstehung der Amblyopie. Experimentelle Untersuchungen, G.K. v.
Noorden Ber. Dtsch. Ophthalmol. Ges. 77, 815 – 828 (1980), P. 821, Abb. 4a
Presbyopie      Presbyacusis

physiological,   pathological,
 mechanical      sensorineural
Charles Eyries,        André Djurno,
Otologist in Paris   Engineer co-working
                         with Eyries
Fritz Zöllner          Wolf Dieter Keidel,
Otologist in Freiburg   Physiologist in Erlangen
History of the Cochlear Implant

 Vision for a technology that
  would enable the deaf to hear

 Research supported by public
  donation, commenced 1967

 First cochlear implant, 1978,
  Melbourne Hospital

 “In spite of the problems and criticisms, I just had to go on.
 A cochlear implant was their only hope of ever hearing.”
 Professor Graeme Clark
Prof. Dr. Dr. med. dent. hc. Ernst Lehnhardt
The Window
    of
Opportunity
Sharma et al, 2002

Ear and Hearing, December 2002
Sharma et al, 2004
                 450
                 400
                 350                                                                                   13 month old recipient
P1 latency, ms




                 300
                 250
                 200                                                                                        At CI activation
                 150
                 100                                                                                       1 week post CI
                 50        Normal limits                                                                   1 month post CI
                  0
                       0            5      10   15                           20           25      30        3 months post CI
                                                Age                                                         12 months post CI
                                                                       350
                                                                       300
                                                      P1 latency, ms



                                                                       250
                                                                       200
14 month old recipient
                                                                       150
                                                                       100
                                                                       50
                                                                                  Normal limits
                                                                        0
                                                                             0                    12              24             36
                                                                                                         Age
           Archives of Otolaryngology – Head & Neck Surgery, May 2004
Categories of Auditory Performance
ref: P Govaerts, C De Beukelaer et al., Neurotology and Audiology 2002 (Antwerp)

                                               Children with normal hearing

                                                            use of telephone




                                          discrimination of speech sounds



                                                response to speech sounds
Govaerts, et al. 2002

                                       Age at Mainstream Integration

                          100
 Percentage of children




                          80                                            Age at
                                                                        implantation
                          60                                                Under 2 yrs
                          40                                                2 to 4 yrs

                          20

                           0
                                0          3                    5   7
                                               Age (in years)



Otology & Neurology, vol 23; 2002
Manuel Manrique,
                                                                                 et al (2004)




                                                                         Reynell

                                                    7
                            "Reynell" age (years)

                                                    6
            < 2 yrs                                 5
                                                    4
                                                    3
            2 to 6 yrs                              2
                                                    1
                                                    0
                                                        0   1   2          3        4           5   6   7
                                                                    Chronological age (years)


Laryngoscope, August 2004
Svirsky, et al (2004)
                                         Average Language Development

                           84
 Expressive Language Age




                           72
                           60
         (months)




                                                                              12-24 months
                           48
                                                                              25-36 months
                           36
                                                                              37-48 months
                           24
                           12
                            0
                                0   12     24    36    48      60   70   84
                                                AGE (months)

Audiology and Neuro-Otology, vol. 9, 2004
Lone Percy-Smith
   E. Danish CI centre, Gentofte Hospital University of
              Copenhagen. October 2007

   Factors associated with Speech/Language
       Outcomes and Social Well-being
               for Children with
         Cochlear Implant in Denmark

N=168. 91 girls. 77 boys.
Age 1-18yrs. Mean age if CI = 4 years
50 spoken language 85 support sign 30 sign
Lone Percy-Smith continued




Summary – Speech and Language Data
tests scored for HA, not CA.
• Strong statistical effect of communication mode
    at home
• Clear improvement of sp./lang. dev. for children
    exposed to spoken Danish only
• Parent assessments and test responses are highly
    positively associated. (auditory capacity and
    speech intelligibility)
Lone Percy-Smith conclusions




• 64% of CI children had high level of social wellbeing
• 36% of CI children with low level
   - 57% operation age >36 mon
   - 68% in schools or kindergarten for deaf
   - 85% use sign support or sign language

   Level of social well being significantly associated with
   communication mode.
Early implantation

Waltzman S & Roland T. 2005 Pediatrics
‘Cochlear Implantation in Children Younger
than 12 Months’

James A. & Papsin J. 2004 The Laryngoscope
‘Cochlear Implant Surgery at 12 Months
of Age or Younger’.

Colletti V. et al. 2005 The Laryngoscope
‘Cochlear Implantation at under 12 Months:
 Report on 10 Patients.’
Vision



 In 20 years, an implant will
be the treatment of choice for
   anyone with a hearing loss
       greater than 50 dB
    Dr Jay Rubenstein , March 2004
Thank you for your attention!

Differences in the sensitive phase of the maturation of the auditory and visual pathways - Dr. Dr. h. c. Monika Lehnhardt

  • 1.
    Differences in thesensitive phase of the maturation of the auditory and visual pathways Dr. Dr. hc. Monika Lehnhardt Cernobbio, June 2008
  • 2.
    „Direct stimulation ofthe auditory nerves with resultant speech perception is not feasible M. Lawrence, 1964
  • 3.
    “It is acrime to provide deaf children with a cochlear implant” German physiologist R. Klinke, 1988
  • 4.
    From: “Strabismus undMotilität” Zur Entstehung der Amblyopie. Experimentelle Untersuchungen, G.K. v. Noorden Ber. Dtsch. Ophthalmol. Ges. 77, 815 – 828 (1980), P. 821, Abb. 4a
  • 5.
    Presbyopie Presbyacusis physiological, pathological, mechanical sensorineural
  • 7.
    Charles Eyries, André Djurno, Otologist in Paris Engineer co-working with Eyries
  • 8.
    Fritz Zöllner Wolf Dieter Keidel, Otologist in Freiburg Physiologist in Erlangen
  • 10.
    History of theCochlear Implant  Vision for a technology that would enable the deaf to hear  Research supported by public donation, commenced 1967  First cochlear implant, 1978, Melbourne Hospital “In spite of the problems and criticisms, I just had to go on. A cochlear implant was their only hope of ever hearing.” Professor Graeme Clark
  • 11.
    Prof. Dr. Dr.med. dent. hc. Ernst Lehnhardt
  • 12.
    The Window of Opportunity
  • 13.
    Sharma et al,2002 Ear and Hearing, December 2002
  • 14.
    Sharma et al,2004 450 400 350 13 month old recipient P1 latency, ms 300 250 200  At CI activation 150 100 1 week post CI 50 Normal limits 1 month post CI 0 0 5 10 15 20 25 30  3 months post CI Age  12 months post CI 350 300 P1 latency, ms 250 200 14 month old recipient 150 100 50 Normal limits 0 0 12 24 36 Age Archives of Otolaryngology – Head & Neck Surgery, May 2004
  • 15.
    Categories of AuditoryPerformance ref: P Govaerts, C De Beukelaer et al., Neurotology and Audiology 2002 (Antwerp) Children with normal hearing use of telephone discrimination of speech sounds response to speech sounds
  • 16.
    Govaerts, et al.2002 Age at Mainstream Integration 100 Percentage of children 80 Age at implantation 60 Under 2 yrs 40 2 to 4 yrs 20 0 0 3 5 7 Age (in years) Otology & Neurology, vol 23; 2002
  • 17.
    Manuel Manrique, et al (2004) Reynell 7 "Reynell" age (years) 6 < 2 yrs 5 4 3 2 to 6 yrs 2 1 0 0 1 2 3 4 5 6 7 Chronological age (years) Laryngoscope, August 2004
  • 18.
    Svirsky, et al(2004) Average Language Development 84 Expressive Language Age 72 60 (months) 12-24 months 48 25-36 months 36 37-48 months 24 12 0 0 12 24 36 48 60 70 84 AGE (months) Audiology and Neuro-Otology, vol. 9, 2004
  • 19.
    Lone Percy-Smith E. Danish CI centre, Gentofte Hospital University of Copenhagen. October 2007 Factors associated with Speech/Language Outcomes and Social Well-being for Children with Cochlear Implant in Denmark N=168. 91 girls. 77 boys. Age 1-18yrs. Mean age if CI = 4 years 50 spoken language 85 support sign 30 sign
  • 20.
    Lone Percy-Smith continued Summary– Speech and Language Data tests scored for HA, not CA. • Strong statistical effect of communication mode at home • Clear improvement of sp./lang. dev. for children exposed to spoken Danish only • Parent assessments and test responses are highly positively associated. (auditory capacity and speech intelligibility)
  • 21.
    Lone Percy-Smith conclusions •64% of CI children had high level of social wellbeing • 36% of CI children with low level - 57% operation age >36 mon - 68% in schools or kindergarten for deaf - 85% use sign support or sign language Level of social well being significantly associated with communication mode.
  • 22.
    Early implantation Waltzman S& Roland T. 2005 Pediatrics ‘Cochlear Implantation in Children Younger than 12 Months’ James A. & Papsin J. 2004 The Laryngoscope ‘Cochlear Implant Surgery at 12 Months of Age or Younger’. Colletti V. et al. 2005 The Laryngoscope ‘Cochlear Implantation at under 12 Months: Report on 10 Patients.’
  • 23.
    Vision In 20years, an implant will be the treatment of choice for anyone with a hearing loss greater than 50 dB Dr Jay Rubenstein , March 2004
  • 24.
    Thank you foryour attention!