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~BN12 synaptic transmission.ppt

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  • NSF = NEM sensitive fusion protein it is an ATPase
  • NSF = NEM sensitive fusion protein it is an ATPase
  • Transcript

    • 1. Synaptic Transmission Lecture 12
    • 2. Synapses
      • Communication b/n neurons
      • Electrical
        • Electrotonic conduction
      • Chemical
        • Ligand / receptor ~
    • 3. Electrical Synapses
      • Tight junctions
        • Connexons
        • Passive current
        • & larger molecules (e.g., ATP)
      • Synchronous activity
        • Breathing
        • Hormone release from hypothalamus ~
    • 4. Synaptic Transmission
      • Nature of signal across synapse?
      • Sherrington
        • electrotonic transmission
      • Most neural conduction too slow
        • Delay in spinal reflexes ~
    • 5. Synaptic Transmission
      • Otto Loewi had a dream
        • Chemical Signal?
        • How can it be demonstrated?
      • Frog Heart Preparation ~
    • 6.
      • Stimulate Vagus
        • Heart rate slows ~
      electrical stimulation -
    • 7.
      • Stimulate A
        • Collect fluid ~
      A B -
    • 8.
      • Perfuse heart B
      • Heart B slows
        • chemical = vagusstoff ~
      A B -
    • 9.
      • Repeat w/ accelerator nerve
        • HR increases
        • Acceleransstoff ~
      B A +
    • 10. The Chase Is On
      • Search for chemical neurotransmitters (NT)
      • Criteria
      • Synaptic Model ~
    • 11. Synaptic Events
      • Action Potential reaches axon terminal
      • Chemical substance released
        • Neurotransmitter (NT)
      • Diffuses across synapse
      • Binds to receptor protein
        • EPSP or IPSP ~
    • 12.
      • 1. Precursor transport
      • 2. NT synthesis
      • 3. Storage
      • 4. Release
      • 5. Activation
      • 6. Termination ~
      Synaptic Transmission Model
    • 13. Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine
    • 14. 1. Precursor Transport
    • 15. E 2. Synthesis Enzymes & cofactors ~
    • 16. 3. Storage E
    • 17. Synapse Terminal Button Dendritic Spine 3. Storage In vesicles
    • 18. Synapse 4. Release
      • via exocytosis
      • diffusion
      Ca++ AP
    • 19. Exocytosis: Membrane Fusion
      • Ca 2+ influx
        • 2 d messenger
        • Ca 2+ -Calmodulin
      • SNAPs
        • soluble-NSF-attachment proteins
      • SNAREs
        • SNAP receptors ~
    • 20.
        • NT binds to receptor
      5. Activation
    • 21. Activation
      • NT binds to postsynaptic receptor
        • opens ion channel
        • EPSP
          • Na+ into cell
        • or IPSP
          • K+ out of cell ~
    • 22. 6. Termination
      • 4 Basic methods
        • Diffusion
        • Enzymatic degradation
        • Presynaptic reuptake
          • active transport
        • Autoreceptors ~
    • 23.
        • autoreceptors
      6. Termination A
    • 24. Autoreceptors
      • On presynaptic terminal
      • Binds NT
        • same as postsynaptic receptors
        • different receptor subtype
      • Decreases NT release & synthesis ~
    • 25. Termination
      • Must have discrete signal
      • What if ion channels continually open?
        • ions move toward equilibrium
        • membrane no longer polarized
        • no EPSPs or IPSPs
      • Disrupts neural communication
      • Termination ---> neuron repolarizes ~
    • 26. Exocytosis: Membrane Fusion
      • Ca 2+ influx
        • 2 d messenger
        • Ca 2+ -Calmodulin
      • SNAPs
        • soluble-NSF-attachment proteins
      • SNAREs
        • SNAP receptors ~

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