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Karen Nunley Presentation

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2nd Annual DCC Retreat

2nd Annual DCC Retreat

Published in: Health & Medicine

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  • 1. BIOMONITORING: A PLAN FOR DELAWARE DELAWARE CANCER CONSORTIUM RETREAT FEBRUARY 15, 2010 Karen Nunley, M.S.
  • 2. MULTI-MEDIA EXPOSURE STUDY
    • Introduction
    • Biomonitoring
      • Benefits
      • Limitations
    • Delaware’s Plan
    • Discussion / Q & A
  • 3. MULTI-MEDIA EXPOSURE
  • 4. MULTI-MEDIA EXPOSURE
  • 5.
    • CHEMICALS ENTER THE BODY VIA:
      • Dermal Absorption
      • Inhalation
      • Ingestion
      • Injection
  • 6. MULTI-MEDIA EXPOSURE
  • 7. WHAT IS BIOMONITORING?
    • Measuring human tissue and bodily fluids for the presence of chemicals or their metabolites
  • 8. WHAT IS BIOMONITORING?
    • Measuring human tissue and bodily fluids for the presence of chemicals or their metabolites
    • Provides information about the ‘internal’ dose rather than the ‘external’ concentration
  • 9.  
  • 10. EFFECTS DEPEND ON:
    • Exposure route
    • Exposure duration
    • Exposure frequency
    • Exposure intensity
  • 11. HISTORY
    • Used in late 1800s to test workers for lead and to monitor salicyluric acid levels in people being treated for rheumatism
    • Historically used in occupational settings
  • 12. HISTORY
    • In the last few decades, expanded to measure chemical exposures in the general population
  • 13. BIOMARKERS
    • Exposure
    • Effect
    • Susceptibility
  • 14.
    • All substances are poisons; there is none which is not a poison. The right dose differentiates a poison from a remedy ( Paracelsus, 1567)
  • 15.  
  • 16. BENEFITS
  • 17.  
  • 18.  
  • 19.  
  • 20.  
  • 21.  
  • 22.  
  • 23. LIMITATIONS
  • 24.
    • Only a snapshot of exposure
    • Exposure  Disease
    • Cannot reveal exposure sources or routes
    • Influence of personal behaviors, genetics
    • Unknown additive/synergistic effects of chemicals
    • Ethical issues
  • 25. DELAWARE’S BIOMONITORING PLAN
  • 26. DELAWARE’S BIOMONITORING PLAN
    • Pilot three target areas
    • Approximately 400 Delawareans ages18 and older
    • Samples collected summer and winter; repeat over 2-3 years
    • Expand to statewide sampling
  • 27. DELAWARE’S BIOMONITORING PLAN
    • Testing for variety of substances
      • Blood, urine, hair samples
    • Extensive questionnaire
    • Environmental Samples
      • Water, air, soil/dust
  • 28. DELAWARE’S BIOMONITORING PLAN
    • Prospective Study
    • Archive samples for future testing
    • Create database
  • 29. DATABASE FUNCTIONS:
    • Detect which chemicals are present in Delawareans, and in what concentrations
    • Regional exposure variance
    • Exposure disparities
    • Monitor changes over time
    • Evaluate Public Health programs
  • 30. FUTURE USES:
    • Enact and evaluate effectiveness of exposure reduction strategies
    • Support legislation
    • Provide data to support future epidemiological studies via linkage to disease and hospitalization records
    • Decrease uncertainty inherent in exposure risk assessments
  • 31. WILL NOT:
      • Sample every Delawarean
      • Provide full exposure history
      • Identify exact exposure source(s) or disease causation
      • Identify who will or will not develop a disease endpoint
  • 32. Q & A
  • 33. THANK YOU! Karen Nunley, M.S.