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Automatic Classification of Drusen Geometries in AMD Patients
- 1. FINAL PROJECT REPORT Automatic Classification of Different Geometries of Drusen in patients with Age related Macular Degeneration -Darshan Shah
- 2. PROJECT OVERVIEW What is the project about?
- 3. PROJECT OVERVIEW GOAL The goal of this project is to create a GUI to automatically segment Drusen and categorize the Drusen into its various types Image courtesy harbour.com
- 4. PROJECT OVERVIEW SCOPE This project will help the eye examiners to find Drusen in the image and help save time in categorizing Drusen thereby speedingHomogeneity (Comparing area between up the examination of the retina. RPE and Choroid) Homogeneity (Comparing area between RPE and Choroid) Image courtesy ophmanagement.com
- 5. LITERATURE REVIEW KEY PAPER Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration - Khanifar Aziz et al 2008 Quantitative Comparison of Drusen Segmented on SD-OCT versus Drusen delineated on Color Fundus Photographs- Nieraj Jain et al 2010 Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation - Stephanie J. Chiu 2010
- 7. HOMOGENEITY (COMPARING AREA BETWEEN RPE AND CHOROID) Homogeneous – compare the entire layer for uniformity Non-homogeneous with a central core – varying internal reflectivity with a distinct single focus of hyper- reflectivity Non-homogeneous without a central core– varying internal reflectivity
- 10. SEGMENTED REGION
- 11. ATTEMPTED METHOD 1 Taking max values along the vertical gradients
- 12. ATTEMPTED METHOD 2 Convolving with a binary mask depending on weights
- 13. METHOD 3 GRAPH THEORY Implementation of Stephanie Chiu’s algorithm Using Dijkstra Algorithm to implement lowest weighted path
- 16. SO GETTING BACK TO SEGMENTED
- 17. DATA SET OF UNSEGMENTED IMAGES mean before Std before Image no Separate layer exists? segmentaion segmentation 51 yes 162.0504 35.2787 52 yes 156.1071 39.2795 53 yes 164.7804 38.8632 54 yes 162.8016 37.2076 55 yes 163.5681 35.8284 56 yes 172.4292 39.5759 57 yes but hardly 182.4318 37.7275 58 yes but hardly 185.2433 31.3095 59 yes but hardly 178.0332 33.8844 60 yes but hardly 167.4353 34.3635 61 not really 179.9425 35.9614 62 really bright 177.7636 34.5737 63 not really 181.2146 36.3007 64 separable diff with RPE 172.3632 31.1072 65 not really 179.5103 31.5538 66 no 183.3249 32.8943 67 not really 179.101 34.1617 68 no 184.9984 31.9882 69 no 184.9699 34.9764 70 no but some pecularity 183.9566 34.4765
- 18. BASED ON THIS ANALYSIS A cut-off value for applying the segmentation was decided If the values was above the cut off it was not segmented and the software proceeds with classification directly RUN CODE
- 19. RESOURCES Literature Paper of Khanifar Reference Matlab GUI code Project GUI Web handbook resource
- 20. RFERENCES Toth CA, Farsiu S, Khanifar AA, Chong G, Application of Spectral Domain OCT in AMD, in Optical Coherence Tomography in Age-Related Macular Degeneration, Gabriel Coscas (Editor), (Springer Medizin Verlag Heidelberg, 2009), pp. 15-34: S.J. Chiu, X.T. Li, P. Nicholas, C.A. Toth, J.A. Izatt, S. Farsiu. “Automatic Segmentation of Seven Retinal Layers in SDOCT Images Congruent with Expert Manual Segmentation.” Optics Express. Vol. 18, No. 18, pp. 19413-19428, August 2010. N. Jain, A. A. Khanifar, S. Farsiu, S. Bearelly, S. J. Chiu, K. P. Winter, J. A. Izatt, and C. A. Toth, Qualitative Comparison of Segmented Drusen on SD OCT versus Drusen Delineated on Color Fundus Photograph Presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Fort Lauderdale, FL. May 2009. Dijktra code by Joseph Kirk-matlab mathworks Adjancey matrix code by Kevin Murphy - matlab mathworks
- 21. QUESTIONS?
- 22. APPENDIX
- 23. LAYERS OF THE RETINA-1 Image courtesy pcli.com
- 24. LAYERS OF THE RETINA-2 Image courtesy retinal physician
- 25. PRL
Editor's Notes
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- What is the project about?Define the goal of this projectIs it similar to projects in the past or is it a new effort?Define the scope of this projectIs it an independent project or is it related to other projects?* Note that this slide is not necessary for weekly status meetings
- What is the project about?Define the goal of this projectIs it similar to projects in the past or is it a new effort?Define the scope of this projectIs it an independent project or is it related to other projects?* Note that this slide is not necessary for weekly status meetings
- What is the project about?Define the goal of this projectIs it similar to projects in the past or is it a new effort?Define the scope of this projectIs it an independent project or is it related to other projects?* Note that this slide is not necessary for weekly status meetings
- What are the dependencies that affect the timeline, cost, and output of this project?
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