Infographic: Breast Cancer and Genetics

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Breast cancer is the most common cancer among American women (American Cancer Society), but only 5-10 percent of breast cancer cases are hereditary. Of those cases, roughly 20-25 percent are linked to …

Breast cancer is the most common cancer among American women (American Cancer Society), but only 5-10 percent of breast cancer cases are hereditary. Of those cases, roughly 20-25 percent are linked to mutations in the BRCA1 and BRCA2 genes (BRCA stands for BReast CAncer susceptibility). View the infographic above for more on the genetics of breast cancer.

For more information on breast cancer, visit the website for Dana-Farber’s Susan F. Smith Center for Women’s Cancers Breast Oncology Program: http://www.dana-farber.org/Adult-Care/Treatment-and-Support/Breast-Cancer.aspx

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  • 1. Breast Cancer and Genetics of breast cancer cases are hereditary “An alteration or a mutation in a gene (BRCA 1, 2) does not equal cancer, and of these, BRCA mutations are responsible for approximately 20– 25% of the diagnoses. it just means there is an increased risk.” Huma Rana, MD, Cancer Geneticist, Dana-Farber Cancer Institute New Breast Cancer Cases Every Year new cases of invasive breast cancer 232,340 in women in 2013 cases of carcinoma in situ (CIS) in 2013 (non-invasive and earliest form of breast cancer) 64,640 Risk of Cancer if you have BRCA 1, 2 mutations Women with inherited alterations in BRCA 1, 2 have a 40-80% chance of developing breast cancer during their lifetimes. 5-10% Family Members with Breast Cancer risk factors 5–10% of women have a mother or sister with breast cancer, and about twice as many have either a first-degree relative or seconddegree relative with breast cancer. for breast cancer • Age • Reproductive and menstrual history • Oral contraceptives • Hormone replacement therapy • Radiation exposure • Alcohol intake • Obesity Bilateral preventative mastectemy can reduce risk of breast cancer by 90%. Curable Breast Cancer Percent of Survival 93% 88% 81% 74% Stage 0 Stage I Stage IIA Stage IIB 67% 41% 49% 15% Stage IIIA Stage IIIB Stage IIIC Stage IV Sources • • • • • Dana-Farber Turning Point, 2009: http://www.dana-farber.org/uploadeFiles/ Library/newsroom/publications/turning-point/2009/TurningPoint_2009.pdf NCI – Genetics of Breast and Ovarian Cancer: http://www.cancer.gov/ cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional/page1 American Cancer Society: http://www.cancer.org/cancer/breastcancer/ overviewguide/breast-cancer-overview-key-statistics American Cancer Society: http://www.cancer.org/cancer/breastcancer/ overviewguide/breast-cancer-overview-survival-rates “Outsmart Your Genes: Understanding BRCA 1/2 Cancer Risk” by Huma Q. Rana, MD, Dana-Farber Cancer Institute, July 2013 S USAN F. S MITH C ENTER FOR W OMEN ’ S C ANCERS