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Lung cancer presentation

Lung cancer presentation






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    Lung cancer presentation Lung cancer presentation Presentation Transcript

    • Maruf Minar Laboratory of Surgery College of Veterinary Medicine CBNU
    •  Lung cancer in dogs: A potentially fatal diagnosis for a dog that can be devastating for the owner.  Lung cancer in dogs is almost always secondary in nature.  Most common in older, medium to large dogs.
    •  There are 2 types of lung cancer diagnosed in dogs:  Primary lung cancer  Metastatic lung cancer Primary lung cancer is defined as lung tumors originating in the lung tissue whereas secondary lung cancer originates elsewhere in the body such as limb bone, mouth or thyroid gland but spread to the lung via bloodstream.
    • Primary Lung Tumor
    • Metastatic Lung Cancer
    •  Primary lung tumors are almost always malignant and are usually carcinomas.  They usually present as large solitary mass visible in the lung on a chest x-ray.  Metastatic or secondary lung cancer are usually found in multiple, not as single mass.
    •  No straightforward etiology.  Non-lethal genetic mutations in the DNA can make changes in the regulation of cell death and replacement deviate from the normal.  Surrounding environment can be considered.  Secondary smoking from the smoker owners.  Asbestos can be a cause of a specific form of lung cancer called mesothelioma.
    •  Both male and female dogs are susceptible.  Increase risk associated with living in urban area.  Average age of diagnosis is 11 years.  Short-nosed dogs have twice the risk as medium or long-nosed dogs.
    •  Chronic coughing which may also produce phlegm or blood.  Exercise intolerance (lethargy).  Weight loss and loss of appetite.  Distressed breathing or shortness of breath.  Occasional lameness if the cancer spreads to the bone.
    •  History: 1. Duration of the disease. 2. Surrounding environment.  Physical Examination: 1. Abnormal or muffled lung sounds indicating dyspnea. 2. Enlarged lymph nodes or skin lesions.
    •  Diagnostic tests: 1. Complete blood count 2. Biochemical profile (blood sugar, blood proteins, electrolytes. 3. Urinalysis 4. Chest radiographs: Single most important tool for preliminary diagnosis. 5. Fine needle aspirate of lung mass. 6. Bronchoscopy 7. Advanced imaging: CT and MRI.
    •  Primary lung tumors frequently found in the caudal lobe, usually single mass (unless spread).  Metastatic tumors are multiple and found in a variety of lung lobes.
    • Left: single mass located in one of the lung lobes. Right: Multiple round masses in the lungs representing metastatic forms of tumors.
    • Lung lobe tumor (black arrows) in one of the caudal lung lobes.
    • Pleural effusion resulting from lung tumor
    •  CT and MRI provide more accurate information on staging for resectability and detection of occult metastasis and hilar lymph node enlargement.
    • Primary Tumor T-0 No evidence of neoplasia T-1 Solitary lung tumor surrounded by lung or visceral pleura T-2 Multiple lung tumors of various sizes T-3 Lung tumor invading adjacent tissue Node N-0 No evidence of lymph node involvement N-1 Bronchial lymph node involvement N-2 Distant lymph node involvement Metastasis M-0 No evidence of metastasis M-1 Evidence of distant metastasis with site specified * 37-55% dogs have T-1 disease at surgery, 22-25% have lymph node metastasis and 8% have distant metastasis.
    •  Single lung lobe tumors are removed surgically.  Multiple lung lobe tumors are usually metastatic- cancer spread from another site and treated with chemotherapy.
    •  Each lung lobe can be removed separately.  Through an incision in the side of the chest (“Lateral thoracotomy”), just behind the forelimb.  Incision goes between the ribs, spreading apart and then brought back together once the lung lobe has been removed.  The vessels and bronchus to the lobe are either tied off with suture or with stapler.
    •  Median sternotomy for large tumors and inspection of other lung lobes.
    • • Animal in lateral recumbency • 2cm caudal to the scapula– 4th or 5th intercostal space
    •  Latissimus dorsi and pectoralis muscles are incised parallel to the skin incision
    • 1. Inserting a finger deep latissimus dorsi, locate the 1st rib and 5th rib 2. 5th rib is identified by the caudal insertion of the scalenus muscle and the cranial origin of the external abdominal oblique muscle. Incise either muscle depending on the inercostal space to be entered
    • • Incise serratus ventralis muscle. Note branch of the intercostal artery supplying each belly of serratus ventralis • Incise intercostal muscles midway
    • • Bluntly puncturing the pleura and extending the incision with scissor dorsally to the tubercle of the rib and ventrally past the costochondral arch to the internal thoracic vessels
    • • Unaffected lung lobes are packed out of the way with moist laparotomy sponges • Pulmonary vessels and the lobar bronchus are identified • Hilar dissection. • Dissect pulmonary artery. Triple ligate with two encircling sutures and one transfixation. Transect between the two distal sutures.
    • • Pulmonary vein approached on the ventral side of the bronchus • Two encircling and one transfixing ligatures. Transect the vein • The main bronchus dissected. Cross-clamped with two pairs of non-crushing-type forceps. Transect
    • • Bronchus is sutured with interrupted horizontal mattress suture (collapse the bronchus) • The bronchus is transected just distal to these suture. • The bronchial suture line is tested for air leakage: 1. Flood the thorax with warm saline 2. Ventilate the animal 25 to 30cm H2O pressure 3. Additional suture may by placed to close major leaks
    • • A 2 inches lung lobe tumor in a caudal lung lobe. A black suture has been passed around the large artery to the lobe. • The ribs have been spread apart to expose a lung lobe tumor in a middle lung lobe.
    • • The stapler has been placed across the lung lobe to seal the end of the lobe. • Appearance of the site after the lobe has been stapled off and removed (Black arrow).
    • • Rib apposition • Four cruciate, or four to six encircling suture placed around the ribs, cranial and caudal to the thoracotomy • Place traction of one or more of the suture while the remaining sutures are tied
    • • Placement of circumcostal suture will entrap intercostal nerves • Transcostal suture may lessen postoperative pain
    • • Before closing the thoracotomy, a thoracostomy drain is placed to establish negative pressure in the pleural space • Reappose muscles separately • Close subcutis and skin routinely
    • The chest tube is used to remove excess fluid or air and to install a local anesthetic to block pain.
    •  Monitor if hypoventilation, hypoxemia occur  Pain control  Chest tubes are aspired frequently (every 2- 4hours), and the amount of air is quantitated  Chest tubes are generally removed in 24-48 hours if air is not accumulating
    •  The prognosis is generally good for dogs with single primary lung tumor, small mass in the lungs that has not been spread to the lymph nodes or other tissue.  More than 50% are expected to survive 1 year after removal of mass.