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Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
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Phylogenetic Study of Mdm2

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A phylogenetic study og Mdm2 using tools like ClustalW2 and unrooted trees.

A phylogenetic study og Mdm2 using tools like ClustalW2 and unrooted trees.

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  • 1. Phylogenetic Study of mdm2Yosok PunY
  • 2. p53 and mdm2 interactions
  • 3. Mdm2Negative regulator of p53 tumor suppressorgeneDiscovery from transformed mouse cell lineMdm2 over expression with Ras oncogene ledto tumor formation in nude miceHuman homolog is sometimes called Hdm2
  • 4. Mdm2Increased levels ofmdm2 found in:Soft tissue sarcomasOsteosarcomasBreast tumors
  • 5. Cn3D
  • 6. E3 ligase activityTargets both itself and p53for degradation byproteasomeInhibitor of MDM2-p53interactions is nutlinMDM2 also interacts withubiquitin protease, USP7that reversesubiquitylation to preventdegradation withproteasomeFine regulatory circuit
  • 7. JalView
  • 8. Mdm2 [Homo sapiens] FASTA>gi|155183770|gb|ABT17086.1| Mdm2 [Homo sapiens]MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSE
  • 9. ClustalW2
  • 10. HomoloGeneHomologs werediscovered in thesevertebrates:Chimpanzee, Rhesusmacaque, Dog,Cattle, House mouse,Brown rat, RedJunglefowl, Zebrafish
  • 11. ReferencesHarris. Curtis C. et. al. Proceedings of the National Academy of Sciences.http://www.pnas.org/content/103/6/1659/F1.expansion.html. Accessed May7th2013.Proteasome. Wikipedia. http://en.wikipedia.org/wiki/Proteasome. AccessedMay 7th2013Mdm2. Wikipedia. http://en.wikipedia.org/wiki/Mdm2. Accessed May 7th2013.Knappskog et. al. MDM2 promoter SNP285 and SNP309; phylogeny andimpact on cancer risk. PubMed Central.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260817/. Accessed May 13th2013Jayaraman A et. al. The interaction of p53 and MDM2 genes in cancers, insilico studies and phylogenetic analysis. Biology and Medicine Vol 3 (3): 01-12, 2011.Databases/Tools Used: NCBI Protein. NCBI BLASTp. ClustalW2.ClustalW2 Phylogeny. Cn3D. HomoloGene.

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