PRE-IMPLANTATION GENETIC TESTING(BABI) DURING IN VITROFERTILIZATIONYosok Pun
MICROSCOPE STAGE WITHMICROMANIPULATORS (IVF)
IVF TECHNIQUE Monitor and stimulate the development of healthy  egg(s) in the ovaries. Collect the eggs. Secure the spe...
BABI Acronym    for Blastomere Analysis  Before Implantation. Currently used as a diagnostic testing  of four diseases....
A CELL OR BLASTOMERE BEING REMOVEDFROM A DAY 3 EMBRYO
BLASTOMERE ANALYSIS
DNA AMPLICATION
CYSTIC FIBROSIS Cystic fibrosis is a hereditary disease affecting the  exocrine (mucus) glands of the  lungs, liver, panc...
DOWN SYNDROME Caused by having an extra third copy of  chromosome 21, usually by a random error in the  mothers egg Caus...
DOWN SYNDROME KARYOTYPE
LESCH-NYHAN SYNDROME (LNS) Lesch–Nyhan syndrome (LNS) is a rare inherited  disorder caused by a deficiency of the enzyme ...
X LINK RECESSIVE
TAY–SACHS DISEASE Tay–Sachs disease is a rare autosomal recessive  genetic disorder. In its most common variant  (known a...
CURRENT RULES/LAWS Regulated in UK - Human Fertilization and  Embryology Act was passed in 1990 In US - 1992 Fertility C...
IMPLICATIONSEugenics                       Cons   Debate on eugenics          Little chance that   Screen/weed out bad ...
BABI’S TOLL ON HUMAN LIFE   “savior sibling” that could provide stem cells to cure a sibling with    Fanconis anemia   F...
ETHICAL ANALYSIS   Religious Opposition   Roman Catholic Church, for example, takes the position    that it involves the...
REFERENCES   American Pregnancy Association. In Vitro Fertilization: IVF. Accessed    April 2nd 2013. http://americanpreg...
REFERENCES   UN World Down Syndrome Day. Accessed April 7th 2013.    http://www.un.org/en/events/downsyndromeday/   Righ...
REFERENCES   X Link Recessive. Wikipedia. Accessed April 10th 2013.    http://en.wikipedia.org/wiki/File:XlinkRecessive.j...
Pre-Implantation Genetic Testing (BABI) During IVF
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Pre-Implantation Genetic Testing (BABI) During IVF

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Ethical considerations of BABI

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Pre-Implantation Genetic Testing (BABI) During IVF

  1. 1. PRE-IMPLANTATION GENETIC TESTING(BABI) DURING IN VITROFERTILIZATIONYosok Pun
  2. 2. MICROSCOPE STAGE WITHMICROMANIPULATORS (IVF)
  3. 3. IVF TECHNIQUE Monitor and stimulate the development of healthy egg(s) in the ovaries. Collect the eggs. Secure the sperm. Combine the eggs and sperm together in the laboratory and provide the appropriate environment for fertilization and early embryo growth. Transfer embryos into the uterus. http://www.youtube.com/watch?v=GeigYib39Rs
  4. 4. BABI Acronym for Blastomere Analysis Before Implantation. Currently used as a diagnostic testing of four diseases. Cystic Fibrosis Down Syndrome Tay Sachs Lesch-Nyhan Syndrome
  5. 5. A CELL OR BLASTOMERE BEING REMOVEDFROM A DAY 3 EMBRYO
  6. 6. BLASTOMERE ANALYSIS
  7. 7. DNA AMPLICATION
  8. 8. CYSTIC FIBROSIS Cystic fibrosis is a hereditary disease affecting the exocrine (mucus) glands of the lungs, liver, pancreas, and intestines, causing progressive disability due to multisystem failure. Symptoms include shortness of breath, chronic cough, and wheezing (a whistling sound made with breathing) Current diagnostic tests: blood test to ID defective gene. sweat chloride testing BABI No cure found
  9. 9. DOWN SYNDROME Caused by having an extra third copy of chromosome 21, usually by a random error in the mothers egg Causes mental retardation and affects physical features.
  10. 10. DOWN SYNDROME KARYOTYPE
  11. 11. LESCH-NYHAN SYNDROME (LNS) Lesch–Nyhan syndrome (LNS) is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRT), produced by mutations in the HPRT gene located on (the) X chromosome . LNS affects about one in 380,000 live births Overproduction of uric acid Nervous system impairment Self Injuring Behavior
  12. 12. X LINK RECESSIVE
  13. 13. TAY–SACHS DISEASE Tay–Sachs disease is a rare autosomal recessive genetic disorder. In its most common variant (known as infantile Tay–Sachs disease), it causes a progressive deterioration of nerve cells and of mental and physical abilities that commences around six months of age and usually results in death by the age of four. The disease occurs when harmful quantities of cell membrane components known as gangliosides accumulate in the brain’s nerve cells, eventually leading to the premature death of the cells No cure found
  14. 14. CURRENT RULES/LAWS Regulated in UK - Human Fertilization and Embryology Act was passed in 1990 In US - 1992 Fertility Clinic Success Rate and Certification Act Italy recently passed the new Medically Assisted Reproduction Law in March 2004 It is legal to put embryos in frozen storage in Spain but illegal to destroy embryos or to donate them to research, despite the fact that 74 per cent of Spanish patients with spare embryos in storage would like to donate them to research Embryo Protection Act of 1990 in Germany
  15. 15. IMPLICATIONSEugenics Cons Debate on eugenics  Little chance that Screen/weed out bad couples en masse will genes screen embryos during A society void of IVF. diseases and “ugly” inherited genetic  Disease is not diseases as discussed widespread above. No burden on society to care for the handicapped
  16. 16. BABI’S TOLL ON HUMAN LIFE “savior sibling” that could provide stem cells to cure a sibling with Fanconis anemia Following IVF, a total of 30 human embryos were produced -- 6 affected and 24 normal Of the 24 normal, only five were found to be human leukocyte antigen (HLA)-compatible. In the first IVF cycle two embryos were implanted but failed to grow. Cycles two and three were also failures. The fourth try proved successful and an unaffected child was born, from whose umbilical cord stem cells were retrieved to treat the sibling suffering from Franconis anemia. 6 affected embryos never had a shot at life. Nor did the normal 19 offspring who were not a match for the transplantation. Of the five embryos who were implanted, their chance for survival was only between 10-20%. Thus twenty-nine lives were snuffed out in order to produce one child who could act as a donor for an affected sibling.
  17. 17. ETHICAL ANALYSIS Religious Opposition Roman Catholic Church, for example, takes the position that it involves the destruction of human life Jewish Orthodox religion believes the repair of genetics is okay, but they do not support making a child that is genetically fashioned Family planning via embryo sex selection Eugenics – BABI can currently test for more than 400 conditions, including single gene disorders and chromosomal abnormalities (aneuploidy and translocations Proponents of BABI have argued that over 200 disorders can be prevented by gender selection alone.
  18. 18. REFERENCES American Pregnancy Association. In Vitro Fertilization: IVF. Accessed April 2nd 2013. http://americanpregnancy.org/infertility/ivf.html YouTube. 3D animation of how IVF works. Accessed April 2nd 2013. http://www.youtube.com/watch?v=GeigYib39Rs Right Diagnosis. Blastomere Analysis Before Analysis. Accessed April 5th 2013. http://www.rightdiagnosis.com/test/blastomere_analysis_before_impl antation.htm. Julio E. Pabon, M.D., F.A.C.O.G. Fertility Center and Applied Genetics of Florida Inc. Preimplantation genetic screening for all?. Is it wrong to do genetic testing on all IVF embryos? Accessed April 5th 2013 http://www.geneticsandfertility.com/pgd-or-pgs-is-it-wrong-to- do-genetic-testing-on-all-ivf-embryos/ Munro CL et al. The technology and use of blastomere analysis. American Journal of Obstetrics and Gynecology. 1994 Mar- Apr;23(3):229-34.
  19. 19. REFERENCES UN World Down Syndrome Day. Accessed April 7th 2013. http://www.un.org/en/events/downsyndromeday/ Right Diagnosis. Down Syndrome. Accessed April 7th 2013. http://www.rightdiagnosis.com/d/down_syndrome/intro.htm UN World Down Syndrome Day. Accessed April 7th 2013. http://www.un.org/en/events/downsyndromeday/ Grand Stand Down Syndrome Society. Accessed April 7th 2013. http://www.grandstrandds.org/do-you-have-a-brother-or-sister-with- down-syndrome-do-you-want-to-tell-the-world-how-awesome-they- are/ Down Syndrome Karyotype. Wikipedia. Accessed April 10th 2013. http://en.wikipedia.org/wiki/File:Down_Syndrome_Karyotype.png Lesch Nyhan Syndrome. Wikipedia. Accessed April 10th 2013. http://en.wikipedia.org/wiki/Lesch%E2%80%93Nyhan_syndrome
  20. 20. REFERENCES X Link Recessive. Wikipedia. Accessed April 10th 2013. http://en.wikipedia.org/wiki/File:XlinkRecessive.jpg Tay Sachs disease. Wikipedia. Acccessed April 10th 2013. http://en.wikipedia.org/wiki/Tay%E2%80%93Sachs_disease Malpani Infertility Clinic. Regulating, Reporting & Validating ART. Accessed April 10th 2013. http://www.drmalpani.com/regulating-ivf.htm Preimplantation genetic diagnosis. Wikipedia. Accessed April 10th 2013. http://en.wikipedia.org/wiki/Preimplantation_genetic_diagnosis BABI: Another Anti-Life Genetic Baby Package. Lifeissues.net Accessed April 10th 2013. http://lifeissues.net/writers/mis/mis_06babi.html
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