sponsored by apexenergetics                   RENEWING                THE AGING BRAIN                                     ...
INTENDED USE STATEMENT    The content of this course is intended for informational purposes only. The medical    informati...
DISCLAIMER AND NOTICES   The information and recommendations outlined in this presentation are not intended as a   substit...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
The Glia SystemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                          ...
Healthy and Unhealthy NeuronsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT            ...
How Old is Your Brain?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                   ...
Atrophy of the Memory CentersCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT            ...
The Aging BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                          ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Questions to Ask           • Is it too late?           • Is it permanent?           • What changes can be made?           ...
What are the                                           Earliest Signs of                                           an Agin...
Earliest Signs of an Aging Brain           • Fatigue promoted by brain activity – driving,             reading, brain task...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Autonomic Nervous SystemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                 ...
Moderate Signs of Aging Brain           • Inability to focus or concentrate           • Difficulty learning new tasks     ...
Significant Brain Aging            • Inability to work professionally            • Inability to appreciate life           ...
Severe Brain Aging            • Neurodegenerative disease            • Uncontrolled bladder tone            • Bowel obstru...
Where are you?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                           ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
What are the Mechanisms        for Poor Brain Aging?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(0609201...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Brain Aging of the                                    Memory System                           Dementia and Alzheimer’s Dis...
The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD.                                                    ...
The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD.                                                    ...
The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD.                                                    ...
The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD.                                                    ...
• Are you getting older?                  • Do you have the earliest                    signs of dementia?                ...
Earliest Signs of Dementia           • Poor short-term memory           • Difficulty learning           • Difficulty with ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Papez CircuitCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                            ...
Acetylcholine PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                   ...
Early Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                ...
Progressed Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT           ...
Healthy NeuronCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                           ...
Beta-Amyloid Being CleavedCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT               ...
Beta-Amyloid Plaque FormationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT            ...
Tau ProteinsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                             ...
Neurofibrillary TanglesCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                  ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Clock Drawing TestCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                       ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Acetylcholine PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                   ...
Brain Affected Areas                                      in Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rig...
Symptoms of Cholinergic                                Pathways Degeneration           • Loss of photographic memory      ...
Signs of Cholinergic                                  Pathways Degeneration           • Constantly losing keys, phone, etc...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
ACETYL-CH® ACTIVE (K40)               • Huperzine A               • Alpha-GPC               • N-Acetyl L-Carnitine        ...
Brain Aging of the                                  GABAergic System                          Anxiety, Restlessness, Panic...
GABAergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                       ...
Symptoms of GABAergic                                  Pathway Degeneration         • Feelings of anxiety or panic for rea...
Signs of GABAergic                                     Pathway Degeneration           • Anxiety episodes           • Canno...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
GABATONE® ACTIVE (K39)        •       Valerian Root extract        •       Lithium Orotate        •       Passion Flower e...
Brain Aging of the                           Serotonergic System                         Depression, Loss of Joy, Poor Foc...
Serotonergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                    ...
Symptoms of Serotonergic                             Pathway Degeneration           • Guilty depression           • Inabil...
Signs of Serotonergic                                     Pathway Degeneration           • Social isolation with unwilling...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
SEROTONE® ACTIVE (K38)            •         5-Hydroxytryptophan            •         St. John’s Wort            •         ...
Brain Aging of the                      Dopaminergic System                                 Depression, Loss of Motivation...
Dopaminergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                    ...
Dopamine Receptors in the BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT          ...
Areas of the Brain in DepressionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT         ...
Symptoms of Dopaminergic                          Pathway Degeneration           • Feelings of hopelessness and worthlessn...
Signs of Dopaminergic                                     Pathway Degeneration      •      Depression      •      Isolatio...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
DOPATONE® ACTIVE (K41)       •         Mucuna Pruriens       •         Beta-Phenylethylamine       •         Blueberry ext...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Phosopholipid Integrity                                        60% of the Brain is Made Up                                ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Phosopholipids and Neuron                               StructureCopyright © 2011 Datis Kharrazian. All Rights Reserved.SM...
Neuroscience. 1999;94(1):305-14.                                  Age-related changes in synaptic function:               ...
Int. J Neurosci. 1996 Nove;87(3-4):141-9.                              Essential fatty acids preparation (SR-3) improves  ...
Current Enzyme Inhibition. 2005;1:11-20.                        Sesamin and sesamolin: nature’s therapeutic lignans.      ...
Int J of Biomed Sci. 2006:2:284-288.                            Neuroprotective effects of sesamin and sesamolin          ...
Biochem J. 1982;208(3):631-40.                            Influence of dietary fat on lipid composition                   ...
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(1):83-9.                                 Effects of lecithin-emulsif...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
BRAIN-E® DHA (K53/55/65)                              PHYTO BRAIN-E® (K54)               •         DHA               •    ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Phosopholipids and Neuron                               StructureCopyright © 2011 Datis Kharrazian. All Rights Reserved.SM...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Mitochondria                                           Oxidative                                        PhosphorylationCop...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10.                    Mitochondrial decay in the brains of old rats: ...
Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10.                    Mitochondrial decay in the brains of old rats: ...
Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10.                    Mitochondrial decay in the brains of old rats: ...
Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10.                    Mitochondrial decay in the brains of old rats: ...
J Neurosci Res. 2008 Aug 1;86(10):2339-52.                        Age-related decreases in NAD(P)H and glutathione        ...
Brain Res. 2006 May 23;1090(1):35-44. Epub 2006 May 2.                Age-related changes in glutathione and glutathione-r...
Brain Res. 2006 May 23;1090(1):35-44. Epub 2006 May 2.                Age-related changes in glutathione and glutathione-r...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
GLUTATHIONE RECYCLER® (K57)                  •      Cordyceps extract                  •      Gotu Kola extract           ...
N-Acetyl Cysteine                                                          (Research Review)           • Research has clea...
Alpha Lipoic Acid                                                          (Research Review)           • It directly recyc...
L-Glutamine                                                          (Research Review)           • Research has demonstrat...
Selenium                                                          (Research Review)           • Selenium is a trace elemen...
Cordyceps                                                          (Research Review)           • It has been shown to acti...
Gotu Kola                                                          (Research Review)           • Research has clearly demo...
Milk Thistle                                                          (Research Review)           • Administration of milk...
NEURO-PTX® (K47)           •       N-Acetyl Cysteine           •       N-Acetyl Carnitine           •       Alpha Lipoic A...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Microglia                             NeuroinflammationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(0609...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Brain on FireCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                            ...
Reactive MicrogliosisCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                    ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
NEUROFLAM™ (K46)                   •       Apigenin                   •       Luteolin                   •       Baicalin ...
Mol Nutr Food Res. 2008;52(4):427-38.        Plant-derived polypheonls attenuate lipopolysaccharide-induced               ...
J Neuroinflammation. 2008;25(5):41.                      Apignin and luteolin modulate microglial activation via          ...
J Neuroinflammation. 2008;25(5):41.                      Apignin and luteolin modulate microglial activation via          ...
Neurosci Lett. 2008;448(2):175-179.   Luteolin protects dopaminergic neurons from inflammation-induced             injury ...
Neurosci Lett. 2008;448(2):175-179.   Luteolin protects dopaminergic neurons from inflammation-induced             injury ...
Proc Natl Acad Sci USA. 2008;105(21):7534-7539.                  Luteolin reduces IL-6 production in microglia by inhibiti...
J Pharmacol Exp Ther. 2003;305(2):638-45.                            Flavonoid baicalein attenuates activation-induced    ...
Neurosci Lett. 2008;441(1):16-20.          Neuroprotective effect of baicalein against MPTP neurotoxicity:            beha...
Neuroreport. 2001;12(10):2199-202.                       Baicalein protects cortical neurons from beta-amyloid            ...
Invest Opthalmol Vis Sci. 2008; Nov 14.                                        Baicalein reduces inflammatory process     ...
Brain Res. 2008; Oct 18 [Epub ahead of print].                    Baicalein protects rat brain mitochondria against       ...
Neurochem Res. 2008;33(10):2044-53.              Curcumin protects dopaminergic neuron against LPS induced                ...
Acta Pharmacol Sin. 2007;28(10):1645-51.          Curcumin attenuates the release of pro-inflammatory cytokines           ...
REPAIRVITE® (K60)      •      L-Glutamine      •      MSM      •      Licorice extract      •      Aloe Vera extract      ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Cerebral Blood FlowCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                      ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Blood Flow = FunctionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                    ...
BMC Neurosci. 2010 Jun 24;11(1):78.      Study of the nitric oxide system in the rat cerebellum during aging.           • ...
Brain Res. 2002 Nov 29;956(2):385-92.            Age-related changes of the nitric oxide system in the rat brain.         ...
Biochim Biophys Acta. 1999 May 5;1411(2-3):415-36.                                 Roles of nitric oxide in brain hypoxia-...
Biochim Biophys Acta. 1999 May 5;1411(2-3):415-36.                                 Roles of nitric oxide in brain hypoxia-...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
NITRIC BALANCE® (K62)             •      ATP             •      Huperzine A             •      Vinpocetine             •  ...
NITRIC BALANCE® (K62)           •            Provides compounds that are used to                        support the expres...
Adenosine                                                          (Research Review)              • Adenosine increases ex...
Huperzine A                                                          (Research Review)              •            Huperzine...
Huperzine A                                                          (Research Review)              • Huperzine is a poten...
Huperzine A                                                          (Research Review)                 • Not only does Hup...
Vinpocetine                                                          (Research Review)                 • Vinpocetine is cl...
Vinpocetine                                                          (Research Review)                 • The net effect of...
Vinpocetine                                                          (Research Review)              • In addition to vinpo...
Alpha-GPC                                                          (Research Review)                • Oral intake of Alpha...
Alpha-Ketoglutaric Acid (AKG)                                                          (Research Review)                  ...
Alpha-Ketoglutaric Acid (AKG)                                                          (Research Review)            • AKG ...
Alpha-Ketoglutaric Acid (AKG)                                                          (Research Review)               • A...
Xanthinol Nicotinate                                                          (Research Review)                       It h...
Xanthinol Nicotinate                                                          (Research Review)              • Clinical re...
Acetyl L-Carnitine (LAC)                                                          (Research Review)                • Resea...
Acetyl L-Carnitine (LAC)                                                          (Research Review)              • Acetylc...
NEURO2™ (K45)                •      Ginkgo Biloba                •      Vinpocetine                •      Butcher’s Broom ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Altered Methylation                and Neurodegenerative                       DiseaseCopyright © 2011 Datis Kharrazian. A...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Heijer, T, et al. 2002;1:170-175.      Homocysteine and brain atrophy on MRI of non-demented elderly.           • A study ...
Heijer, T, et al. 2002;1:170-175.      Homocysteine and brain atrophy on MRI of non-demented elderly.Copyright © 2011 Dati...
Heijer, T, et al. 2002;1:170-175.      Homocysteine and brain atrophy on MRI of non-demented elderly.           • The resu...
Heijer, T, et al. 2002;1:170-175.      Homocysteine and brain atrophy on MRI of non-demented elderly.Copyright © 2011 Dati...
A study published in Neurology called the               Rotterdam Scan Study with over 1,000 study               subjects,...
METHYL-SP™ (K14)         •       Folate 1200 mcg (300%)         •       B-12 600 mcg (10,000 %)         •       Choline 50...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Autoimmunity                                   in the Aging BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SM...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Neuroreport. 1995 Jun 19;6(9):1274-6.                                          Immune aging and Alzheimer’s disease.      ...
Gerontology. 1997;43(1-2):79-94.                                  Neuroautoimmunity: pathogenic implications              ...
Clin Rev Allergy Immunol. 2011 Jan 14.                  Autoimmunity and autoantibodies in Parkinson’s disease.          •...
Clin Rev Allergy Immunol. 2011 Jan 14.                  Autoimmunity and autoantibodies in Parkinson’s disease.           ...
J Affect Disord. 2009 Aug;116(3):192-200.                                            Anti-brain antibodies in adult patien...
Cyrex™ Labs               Array 5 - Neuroautoimmunity Panel                                                             Co...
Putting It All TogetherCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                  ...
What State is the Neuron In?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT             ...
What State is the Microglia In?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT          ...
Earliest Signs of an Aging Brain           • Fatigue promoted by brain activity – driving,             reading, brain task...
Moderate Signs of an Aging Brain           • Inability to focus or concentrate           • Difficulty learning new tasks  ...
Significant Brain Aging           • Inability to work professionally           • Inability to appreciate life           • ...
Severe Brain Aging             • Neurodegenerative disease             • Uncontrolled bladder tone             • Bowel obs...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT                                         ...
IMPORTANT & RELEVANT                WEEKEND SEMINARS                                                          DEVELOPED BY...
FUNCTIONAL BLOOD CHEMISTRY                              CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS.    THIS WEEKEND COURSE...
MASTERING THE THYROID                                  CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS.    This course will red...
NEUROTRANSMITTERS & BRAIN                             CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS.   Dr. Kharrazian reviews...
For dates and additional information:                             PLEASE LOOK FOR OUR              WEEKEND & 2-HOUR COURSE...
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Renewing the Aging Brain

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Renewing the Aging Brain

  1. 1. sponsored by apexenergetics RENEWING THE AGING BRAIN Presented by BRANDON BROCK, RN, BSN, MSN/FNP, DC, DACNB, FACFN, FABES, FABVR, FICC, RNCST, CNCT Written by DATIS KHARRAZIAN, DC, DHSc, MS, MNeuroSci, Associate Professor of Clinical Neurology - Carrick Institute Fellow of the American College of Functional Neurology Fellow of the American Board of Vestibular Rehabilitation Fellow of the American Academy of Chiropractic Physicians Diplomate of the American Board of Clinical Nutrition Diplomate of the Board of Nutrition Specialists Diplomate of the International Board of Applied Kinesiology Diplomate of the American Board of Chiropractic NeurologyCopyright © 2011 Datis Kharrazian. All Rights Reserved. Copyright © 2011, Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 1
  2. 2. INTENDED USE STATEMENT The content of this course is intended for informational purposes only. The medical information in this course is intended as general information only and should not be used in any way to diagnose, treat, cure, or prevent any disease. The goal of this course is to present and highlight nutritionally significant information, and offer suggestions and protocols for nutritional support and health maintenance. Homeopathic protocols are intended for use in symptom relief and OTC indications only. It is the sole responsibility of the user of this information to comply with all local and federal laws regarding the use of such information, as it relates to the scope and type of user’s practice. The nutritional protocols and suggestions presented in this course are based on the presenter’s clinical experience and research and are not intended to represent any claims regarding product performance or benefits by the manufacturer, its distributors, or the sponsors of this seminar. Statements regarding nutritional products in this seminar have not been evaluated by the Food and Drug Administration. Nutritional products presented in this seminar are not intended to diagnose, treat, cure, or prevent any disease.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 2
  3. 3. DISCLAIMER AND NOTICES The information and recommendations outlined in this presentation are not intended as a substitute for personalized medical advice. The presentation proposes certain theoretical methods of nutrition, not necessarily mainstream. It is left to the discretion, and it is the sole responsibility of the user of the information indicated in the presentation, to determine if procedures and recommendations described are appropriate for a patient. Neither the authors nor the sponsors (such as Apex Energetics) of this information can be held responsible for the information or any inadvertent errors or omissions of the information. The information in this presentation should not be construed as a claim or representation that any procedure or product mentioned constitutes a specific cure, palliative or ameliorative. Procedures and products described should be considered as adjunctive to other accepted conventional procedures deemed necessary by the attending licensed doctor. It is the concern of the Department of Health and Human Services that no homeopathic and nutritional supplements be used to replace established, conventional medical approaches, especially in cases of emergencies, serious or life threatening diseases or conditions. We share in this concern, as replacing conventional treatment with such remedies, especially in serious cases, may deprive the patient of necessary treatment and thereby cause harm as well as potentially pose a major legal liability for the health professional involved. Apex formulas should not be used as replacements for conventional medical treatment.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 3
  4. 4. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 4
  5. 5. The Glia SystemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 5
  6. 6. Healthy and Unhealthy NeuronsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 6
  7. 7. How Old is Your Brain?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 7
  8. 8. Atrophy of the Memory CentersCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 8
  9. 9. The Aging BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 9
  10. 10. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 10
  11. 11. Questions to Ask • Is it too late? • Is it permanent? • What changes can be made? • Will it get worse?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 11
  12. 12. What are the Earliest Signs of an Aging Brain?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 12
  13. 13. Earliest Signs of an Aging Brain • Fatigue promoted by brain activity – driving, reading, brain tasks • Depression – lack of healthy brain firing leads to depression • Poor Digestive Function – 90% of the brain’s output goes to the pontomedullary systemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 13
  14. 14. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 14
  15. 15. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 15
  16. 16. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 16
  17. 17. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 17
  18. 18. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 18
  19. 19. Autonomic Nervous SystemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 19
  20. 20. Moderate Signs of Aging Brain • Inability to focus or concentrate • Difficulty learning new tasks • Chronic constipation, opportunistic intestinal overgrowth, digestive enzyme insufficiency • Increased sympathetic tone leading to: – Increased blood pressure – Increased resting heart rate – Stress susceptibility – Poor blood flowCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 20
  21. 21. Significant Brain Aging • Inability to work professionally • Inability to appreciate life • Inability to perceive neurological loss • Early signs of neurological disease – tremors – inability to find directions – etc.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 21
  22. 22. Severe Brain Aging • Neurodegenerative disease • Uncontrolled bladder tone • Bowel obstruction and inability to digest food • Inability to taste, smell, or develop social relationships • Dependency on family and medical staff for daily functionsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 22
  23. 23. Where are you?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 23
  24. 24. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 24
  25. 25. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 25
  26. 26. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 26
  27. 27. What are the Mechanisms for Poor Brain Aging?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 27
  28. 28. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 28
  29. 29. Brain Aging of the Memory System Dementia and Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 29
  30. 30. The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD. Memory and the aging brain. • Studies that look at only the healthiest elderly tend to find minimal cognitive decline even into the ninth decade.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 30
  31. 31. The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD. Memory and the aging brain. • It is clear that significant cognitive decline is not an inevitable consequence of advanced age.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 31
  32. 32. The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD. Memory and the aging brain. • More than 4 million Americans have dementia, and the number is projected to grow to 14 million in the next 50 years.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 32
  33. 33. The University of Iowa – Steven Anderson, PhD and Thomas Graboski, MD. Memory and the aging brain. • Currently there is no cure for dementia. • All people are at risk for dementia, with the greatest risk factor being increased age.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 33
  34. 34. • Are you getting older? • Do you have the earliest signs of dementia? • Are you taking this seriously?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 34
  35. 35. Earliest Signs of Dementia • Poor short-term memory • Difficulty learning • Difficulty with directions • Decreased brain endurance If you have the symptoms, when did they start and how fast are they going?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 35
  36. 36. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 36
  37. 37. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 37
  38. 38. Papez CircuitCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 38
  39. 39. Acetylcholine PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 39
  40. 40. Early Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 40
  41. 41. Progressed Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 41
  42. 42. Healthy NeuronCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 43
  43. 43. Beta-Amyloid Being CleavedCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 44
  44. 44. Beta-Amyloid Plaque FormationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 45
  45. 45. Tau ProteinsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 46
  46. 46. Neurofibrillary TanglesCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 47
  47. 47. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 48
  48. 48. Clock Drawing TestCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 49
  49. 49. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 50
  50. 50. Acetylcholine PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 51
  51. 51. Brain Affected Areas in Alzheimer’s DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 52
  52. 52. Symptoms of Cholinergic Pathways Degeneration • Loss of photographic memory • Difficulty with sense of directions • Poor memory • Memory lapses • Poor verbal memory • Slow mental speedCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 53
  53. 53. Signs of Cholinergic Pathways Degeneration • Constantly losing keys, phone, etc. • Constantly forget where car is parked • Dependency on navigations system for directions • Must write everything down • Constantly forgetting appointments, tasks, etc.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 54
  54. 54. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 55
  55. 55. ACETYL-CH® ACTIVE (K40) • Huperzine A • Alpha-GPC • N-Acetyl L-Carnitine • Pantothenic AcidCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 56
  56. 56. Brain Aging of the GABAergic System Anxiety, Restlessness, Panic AttacksCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 57
  57. 57. GABAergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 58
  58. 58. Symptoms of GABAergic Pathway Degeneration • Feelings of anxiety or panic for reasons • Difficulty shutting mind off • Feelings of being overwhelmed for no reason • Disorganized attention • Feelings of restlessnessCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 59
  59. 59. Signs of GABAergic Pathway Degeneration • Anxiety episodes • Cannot initiate projects due to constant distractions • Startled easily and difficulty calming down afterwards • Severely sensitive to light and sound • Increased resting heart rateCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 60
  60. 60. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 61
  61. 61. GABATONE® ACTIVE (K39) • Valerian Root extract • Lithium Orotate • Passion Flower extract • L-Theanine • L-Taurine • Pyridoxal-5-Phosphate • Manganese Succinate • Zinc Glycinate • Magnesium SuccinateCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 62
  62. 62. Brain Aging of the Serotonergic System Depression, Loss of Joy, Poor Focus, Sense of Self and PurposeCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 63
  63. 63. Serotonergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 64
  64. 64. Symptoms of Serotonergic Pathway Degeneration • Guilty depression • Inability to feel joy from hobbies, friends, music, food, etc. • Depressed with overcast weather or chronic lack of sunlight • Loss of interest in lifeCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 65
  65. 65. Signs of Serotonergic Pathway Degeneration • Social isolation with unwillingness to go out • Depression • Cravings and overeating of carbohydrates and sugars • Slowed reflexes and coordinationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 66
  66. 66. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 67
  67. 67. SEROTONE® ACTIVE (K38) • 5-Hydroxytryptophan • St. John’s Wort • SAMe • Pyridoxal 5 Phosphate • Niacinamide • Magnesium Citrate • Methylcobalamin • Calcium FolinateCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 68
  68. 68. Brain Aging of the Dopaminergic System Depression, Loss of Motivation, Inability to Finish Tasks, Slow Movements, Slow MindCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 69
  69. 69. Dopaminergic PathwaysCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 70
  70. 70. Dopamine Receptors in the BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 71
  71. 71. Areas of the Brain in DepressionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 72
  72. 72. Symptoms of Dopaminergic Pathway Degeneration • Feelings of hopelessness and worthlessness • Inability to handle stress • Unable to self-motivate to start or finish tasks • Need to consume caffeine to stay focused • DepressionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 73
  73. 73. Signs of Dopaminergic Pathway Degeneration • Depression • Isolation • Quick to snap at every little thing • Poor compliance with healthcare, exercise, etc. • Anger episodes • Hypokinesia (slow and diminished movements) • Constipation with diminished smell or taste perceptionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 74
  74. 74. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 75
  75. 75. DOPATONE® ACTIVE (K41) • Mucuna Pruriens • Beta-Phenylethylamine • Blueberry extract • D,L – Phenylalanine • N-Acetyl L-Tyrosine • Pyridoxal 5 Phosphate • Alpha Lipoic Acid • Selenium • N-Acetyl L-CysteineCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 76
  76. 76. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 77
  77. 77. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 78
  78. 78. Phosopholipid Integrity 60% of the Brain is Made Up of PhosopholipidsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 79
  79. 79. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 80
  80. 80. Phosopholipids and Neuron StructureCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 81
  81. 81. Neuroscience. 1999;94(1):305-14. Age-related changes in synaptic function: analysis of the role of dietary supplementation. • DHA is used to enhance cell fluidity, neuronal signaling, neuronal dendrite growth, and brain function, as well as reduce inflammation, and decrease the incidence of neurodegenerative conditions.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 82
  82. 82. Int. J Neurosci. 1996 Nove;87(3-4):141-9. Essential fatty acids preparation (SR-3) improves Alzheimer’s patient’s quality of life. • DHA intake has demonstrated the ability to boost brain function, improve quality of life, and reduce the incidence of neurodegenerative conditions.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 83
  83. 83. Current Enzyme Inhibition. 2005;1:11-20. Sesamin and sesamolin: nature’s therapeutic lignans. • Sesamin and Sesamolin found in sesame seed oil and have exhibited properties to protect neurons and modulate microglia neuroinflammatory properties.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 84
  84. 84. Int J of Biomed Sci. 2006:2:284-288. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. • Sesamin and sesamolin have the ability to attenuate excess generation of oxidative stress stimulated by microglia and to reduce infarct size by approximately 50% when compared with the control group in a cerebral artery occlusion study.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 85
  85. 85. Biochem J. 1982;208(3):631-40. Influence of dietary fat on lipid composition of rat brain synaptosomal and microsomal membranes. • Phosphatidylcholine (PC) plays a crucial role in the formation and structural integrity of neurons and brain architecture. • PC supports cell-membrane integrity, fluidizing the membranes, and it supports intracellular communication.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 86
  86. 86. Artif Cells Blood Substit Immobil Biotechnol. 1994;22(1):83-9. Effects of lecithin-emulsified perflurochemical compounds in ischemic brain injury. • Dietary supplementation with Phosphatidylcholine has exhibited protection against oxidative and ischemic neuronal damage.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 87
  87. 87. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 88
  88. 88. BRAIN-E® DHA (K53/55/65) PHYTO BRAIN-E® (K54) • DHA • EPA • Phosphatidylcholine • Sesame oilCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 89
  89. 89. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 90
  90. 90. Phosopholipids and Neuron StructureCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 91
  91. 91. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 92
  92. 92. Mitochondria Oxidative PhosphorylationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 93
  93. 93. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 94
  94. 94. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 95
  95. 95. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 96
  96. 96. Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. • To investigate the mitochondrial decay and oxidative damage resulting from aging, the kinetics of the mitochondrial complexes were examined in the brains of young and old rats as well as in old rats fed alpha- lipoic acid plus acetyl-L-carnitine.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 97
  97. 97. Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. • The brain mitochondria of old rats, compared with young rats, had significantly decreased endogenous antioxidants and superoxide dismutase activity; more oxidative damage to lipids and proteins; and decreased activities of complex I, IV, and V.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 98
  98. 98. Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. • Feeding LA/ALC to old rats partially restored age-associated mitochondrial dysfunction to the levels of the young rats.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 99
  99. 99. Neurochem Res. 2009 Apr;34(4):755-63. Epub 2008 Oct 10. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. • These results indicate that oxidative mitochondrial decay plays an important role in brain aging and that a combination of nutrients targeting mitochondria could ameliorate mitochondrial decay.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 100
  100. 100. J Neurosci Res. 2008 Aug 1;86(10):2339-52. Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. • We conclude that old-aged neurons consume more NADH and glutathione, leading to a catastrophic decline in redox ratio, leading to age-related glutamate excitotoxicity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 101
  101. 101. Brain Res. 2006 May 23;1090(1):35-44. Epub 2006 May 2. Age-related changes in glutathione and glutathione-related enzymes in rat brain. • The most reliable and robust risk factor for some neurodegenerative diseases is aging. • It has been proposed that processes of aging are associated with the generation of reactive oxygen species and a disturbance of glutathione homeostasis in the brain.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 102
  102. 102. Brain Res. 2006 May 23;1090(1):35-44. Epub 2006 May 2. Age-related changes in glutathione and glutathione-related enzymes in rat brain. • The results suggested a significant age- related reduction of reduced glutathione (GSH) level in all brain regions examined, associated with an increase of GSH oxidation to glutathione disulfide (GSSG) and decrease of the GSH/GSSG ratio.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 103
  103. 103. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 104
  104. 104. GLUTATHIONE RECYCLER® (K57) • Cordyceps extract • Gotu Kola extract • Milk Thistle extract • N-Acetyl Cysteine • Alpha Lipoic Acid • L-Glutamine • SeleniumCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 105
  105. 105. N-Acetyl Cysteine (Research Review) • Research has clearly demonstrated that N-Acetyl Cysteine is rapidly metabolized to intracellular glutathione.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 106
  106. 106. Alpha Lipoic Acid (Research Review) • It directly recycles and extends the metabolic life spans of vitamin C, glutathione, and coenzyme Q10, and it indirectly renews vitamin E, all of which are necessary for glutathione recycling.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 107
  107. 107. L-Glutamine (Research Review) • Research has demonstrated that glutamine is important for the generation of glutathione. • It is transported into the cell, converted to glutamate, and readily available for intracellular glutathione synthesis.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 108
  108. 108. Selenium (Research Review) • Selenium is a trace element nutrient that serves as the essential cofactor for the enzyme glutathione peroxidase.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 109
  109. 109. Cordyceps (Research Review) • It has been shown to activate glutathione peroxidase synthesis in the body. • Cordyceps research has demonstrated that it helps protect cells by engaging the glutathione enzyme cycle.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 110
  110. 110. Gotu Kola (Research Review) • Research has clearly demonstrated that oral intake very rapidly and dramatically increases the activity and amount of glutathione perioxidase and the quantity of glutathione.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 111
  111. 111. Milk Thistle (Research Review) • Administration of milk thistle has shown to significantly increase glutathione, increase superoxide dismutase activity, and have a positive influence in the ratios of reduced and oxidized glutathione.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 112
  112. 112. NEURO-PTX® (K47) • N-Acetyl Cysteine • N-Acetyl Carnitine • Alpha Lipoic Acid • Creatine Monohydrate • Genistein • Milk Thistle extract • CoQ10 • Alpha Ketoglutarate • d-alpha tocopherol succinateCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 113
  113. 113. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 114
  114. 114. Microglia NeuroinflammationCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 115
  115. 115. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 116
  116. 116. Brain on FireCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 117
  117. 117. Reactive MicrogliosisCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 118
  118. 118. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 119
  119. 119. NEUROFLAM™ (K46) • Apigenin • Luteolin • Baicalin • Rutin • Catechin • Curcumin (turmeric)Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 120
  120. 120. Mol Nutr Food Res. 2008;52(4):427-38. Plant-derived polypheonls attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. • Apigenin attenuated lipopolysaccharide induced nitric oxide and TNF production in microglia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 121
  121. 121. J Neuroinflammation. 2008;25(5):41. Apignin and luteolin modulate microglial activation via inhibition of STAT-1 induced CD40 expression. • Apigenin and luteolin concentration- dependently suppressed IFN-gamma- induced CD40 expression of microglia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 122
  122. 122. J Neuroinflammation. 2008;25(5):41. Apignin and luteolin modulate microglial activation via inhibition of STAT-1 induced CD40 expression. • Our findings provide further support that apigenin and luteolins anti-inflammatory effects have neuroprotective properties in various neurodegenerative disorders.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 123
  123. 123. Neurosci Lett. 2008;448(2):175-179. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. • Luteolin also significantly inhibited LPS- induced activation of microglia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 124
  124. 124. Neurosci Lett. 2008;448(2):175-179. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. • Our results demonstrate that luteolin may protect neurons by inhibiting microglia activation.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 125
  125. 125. Proc Natl Acad Sci USA. 2008;105(21):7534-7539. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. • Luteolin may be useful for mitigating microglia neuroinflammation.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 126
  126. 126. J Pharmacol Exp Ther. 2003;305(2):638-45. Flavonoid baicalein attenuates activation-induced cell death of brain microglia. • Our current results suggest that baicalein selectively inhibits activated microglia. • Also, inhibiting effects of baicalein were specific for the inflammatory stimulus that activated microglia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 127
  127. 127. Neurosci Lett. 2008;441(1):16-20. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. • The results suggest that baicalein possesses potent neuroprotective activity and has potential anti-Parkinson’s activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 128
  128. 128. Neuroreport. 2001;12(10):2199-202. Baicalein protects cortical neurons from beta-amyloid (25-350 induced toxicity). • Baicalein protects lipoxygenase mediated pathways for micoroglia activated neuroinflammation associated with Alzheimer’s disease.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 129
  129. 129. Invest Opthalmol Vis Sci. 2008; Nov 14. Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy. • Baicalein has demonstrated to ameliorate inflammatory processes of diabetic retinopathy and has inhibitory activity against neuron loss in diabetic retinas.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 130
  130. 130. Brain Res. 2008; Oct 18 [Epub ahead of print]. Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage. • Baicalein has been found to protect neuronal mitochondria damage and swelling promoted by chronic cerebral hypoperfusion and has been suggested as a potential support agent for dementia caused by decreased blood flow to the brain.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 131
  131. 131. Neurochem Res. 2008;33(10):2044-53. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. • Curcumin has demonstrated the ability to protect dopaminergic neurons against lioppolysaccharide induced neurotoxicity in animal neurona/glia culture.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 132
  132. 132. Acta Pharmacol Sin. 2007;28(10):1645-51. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. • Curcumin has been found to have neuroprotective effects by blocking the production of pro-inflammatory and cytotoxic mediators by activated microglia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 133
  133. 133. REPAIRVITE® (K60) • L-Glutamine • MSM • Licorice extract • Aloe Vera extract • Marshmallow extract • Slippery Elm extract • Spanish Moss • German Chamomile extract • Marigold extractCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 134
  134. 134. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 135
  135. 135. Cerebral Blood FlowCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 136
  136. 136. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 137
  137. 137. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 138
  138. 138. Blood Flow = FunctionCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 139
  139. 139. BMC Neurosci. 2010 Jun 24;11(1):78. Study of the nitric oxide system in the rat cerebellum during aging. • In the senescent cerebellum, inducible nitric oxide system activity results in an increase of the protein nitration. • These changes might be related to the oxidative damage detected with aging in the cerebellum.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 140
  140. 140. Brain Res. 2002 Nov 29;956(2):385-92. Age-related changes of the nitric oxide system in the rat brain. • Concerning age, in the cerebellum the eNOS expression decreased whereas iNOS increased.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 141
  141. 141. Biochim Biophys Acta. 1999 May 5;1411(2-3):415-36. Roles of nitric oxide in brain hypoxia-ischemia. • A large body of evidence has appeared over the last 6 years suggesting that nitric oxide biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia-ischemia.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 142
  142. 142. Biochim Biophys Acta. 1999 May 5;1411(2-3):415-36. Roles of nitric oxide in brain hypoxia-ischemia. • In conclusion, it appears that activation of iNOS mediates ischemic brain damage. • However, there is a simultaneous compensatory response through eNOS activation within the endothelium of blood vessels, which mediates vasodilation and hence increases blood flow to the damaged brain area.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 143
  143. 143. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 144
  144. 144. NITRIC BALANCE® (K62) • ATP • Huperzine A • Vinpocetine • Alpha-GPC • Alpha-Ketoglutaric Acid (AKG) • Xanthinol Nicotinate • Acetyl L-CarnitineCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 145
  145. 145. NITRIC BALANCE® (K62) • Provides compounds that are used to support the expression of eNOS and nNOS, while dampening the expression of iNOS. Healthy balance of NO helps the body to: 1. Support tissue healing 2. Dampen tissue inflammation and destruction 3. Modulate autoimmune reactionsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 146
  146. 146. Adenosine (Research Review) • Adenosine increases extracellular ATP, which has been found to activate eNOS and nNOS. • More importantly, it does not activate iNOS activity, and has even demonstrated suppressive iNOS activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 147
  147. 147. Huperzine A (Research Review) • Huperzine A is powerful compound for ideal nitric oxide isomer expression because it enhances acetylcholine activity necessary for eNOS and nNOS, and it has powerful iNOS inhibiting properties.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 148
  148. 148. Huperzine A (Research Review) • Huperzine is a potent natural acetylcholine esterase inhibitor leading to increased acetylcholine activity that is necessary for ideal eNOS and nNOS activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 149
  149. 149. Huperzine A (Research Review) • Not only does Huperzine A inhibit iNOS activity directly, but it also suppresses the same cytokines that stimulate iNOS.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 150
  150. 150. Vinpocetine (Research Review) • Vinpocetine is classified as selective cyclic GMP phosphodiesterase (PDE) inhibitor and modulates vascular tone and nitric oxide release in system circulation.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 151
  151. 151. Vinpocetine (Research Review) • The net effect of PDE inhibitors, such as vinpocetine, is to increase eNOS activity leading to vasodilation and increase blood delivery to peripheral tissues for recovery.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 152
  152. 152. Vinpocetine (Research Review) • In addition to vinpocetine’s properties of eNOS activation, the compound has powerful influences on the neurotransmitter acetylcholine. • Acetylcholine activity is critical for ideal eNOS receptor site activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 153
  153. 153. Alpha-GPC (Research Review) • Oral intake of Alpha GPC has been shown to increase acetylcholine levels in the body. • Acetylcholine activity promotes nitric oxide synthase activity and nitric oxide promotes acetylcholine activity that is responsible for eNOS vascular dilation and nNOS synaptic activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 154
  154. 154. Alpha-Ketoglutaric Acid (AKG) (Research Review) Alpha-Ketoglutaric Acid is a citric cycle intermediate and can be used to help produce nitric oxide via the urea cycle and metabolize harmful nitrogen out of the body.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 155
  155. 155. Alpha-Ketoglutaric Acid (AKG) (Research Review) • AKG supplementation has been shown to have positive modulating activity on iNOS.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 156
  156. 156. Alpha-Ketoglutaric Acid (AKG) (Research Review) • AKG supplementation has been shown to help modulate nitrogen balance and preserve protein synthesis after cell injury.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 157
  157. 157. Xanthinol Nicotinate (Research Review) It has demonstrated properties to increase eNOS by its nicotinate component activity on the acetylcholine receptors.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 158
  158. 158. Xanthinol Nicotinate (Research Review) • Clinical research has found that xanthinol nicotinate has antioxidant properties that may lead to decreased iNOS activities. • Several research studies have found it improves microcirculation and aids in healing.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 159
  159. 159. Acetyl L-Carnitine (LAC) (Research Review) • Research has shown that LAC mimics acetylcholine activity, and has shown effectiveness in acetylcholine-mediated pathways.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 160
  160. 160. Acetyl L-Carnitine (LAC) (Research Review) • Acetylcholine activity promotes nitric oxide synthase activity, and nitric oxide promotes acetycholine activity that is responsible for eNOS vascular dilation and nNOS synaptic activity.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes only 161
  161. 161. NEURO2™ (K45) • Ginkgo Biloba • Vinpocetine • Butcher’s Broom • Feverfew • Cayenne (Capsaicin)Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 162
  162. 162. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 163
  163. 163. Altered Methylation and Neurodegenerative DiseaseCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 164
  164. 164. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 165
  165. 165. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 166
  166. 166. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 167
  167. 167. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 168
  168. 168. Heijer, T, et al. 2002;1:170-175. Homocysteine and brain atrophy on MRI of non-demented elderly. • A study of 1077, non-demented people investigated the association between plasma homocysteine levels and severity of hippocampal, amygdalar, and global brain atrophy on MRI.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 169
  169. 169. Heijer, T, et al. 2002;1:170-175. Homocysteine and brain atrophy on MRI of non-demented elderly.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 170
  170. 170. Heijer, T, et al. 2002;1:170-175. Homocysteine and brain atrophy on MRI of non-demented elderly. • The results concluded higher plasma homocysteine levels are associated with more atrophy of the hippocampus and cortical regions in elderly at risk or Alzheimer’s disease.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 171
  171. 171. Heijer, T, et al. 2002;1:170-175. Homocysteine and brain atrophy on MRI of non-demented elderly.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 172
  172. 172. A study published in Neurology called the Rotterdam Scan Study with over 1,000 study subjects, demonstrated that homocysteine elevations were associated with silent brain infarcts and white matter lesions.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 173
  173. 173. METHYL-SP™ (K14) • Folate 1200 mcg (300%) • B-12 600 mcg (10,000 %) • Choline 50 mg • Trimethlyglycine 550 mg • MSM 50 mg • Beet (Root) 50 mg • Betaine HCl 60 mg • Magnesium 140 mg (35%) • Vitamin C 50 mg (83%) • Vitamin B6 10 mg (500%) • Vitamin E 20 IU (66%) • Riboflavin 10 mg (588%)Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 174
  174. 174. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 175
  175. 175. Autoimmunity in the Aging BrainCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 176
  176. 176. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 177
  177. 177. Neuroreport. 1995 Jun 19;6(9):1274-6. Immune aging and Alzheimer’s disease. • The model thus emerging for sporadic Alzheimers disease is that of a T-cell- mediated chronic autoimmune syndrome following the age-dependent loss of thymic function.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 178
  178. 178. Gerontology. 1997;43(1-2):79-94. Neuroautoimmunity: pathogenic implications for Alzheimer’s disease. • Immune factors such as cellular immunity, autoimmunity, and inflammation may play a pathogenic role in Alzheimers disease (AD), a neurodegenerative disorder.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 179
  179. 179. Clin Rev Allergy Immunol. 2011 Jan 14. Autoimmunity and autoantibodies in Parkinson’s disease. • Recent revelations of immune alterations in Parkinsons disease have led to the convergence that an autoimmune mechanism may play a role. • The presence of seven autoantibodies previously found to be associated with central nervous system manifestations, namely: antineuronal-cells, anti-brain lysate, anti-dsDNA, anti-phosphatidylserine, anti-cardiolipin, anti- serotonin, and anti-melanocytes antibodies.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 180
  180. 180. Clin Rev Allergy Immunol. 2011 Jan 14. Autoimmunity and autoantibodies in Parkinson’s disease. • Clinical manifestations of Parkinsons disease, particularly dyskinesia and depression, were found to be associated with the presence of these autoantibodies.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 181
  181. 181. J Affect Disord. 2009 Aug;116(3):192-200. Anti-brain antibodies in adult patients with obsessive-compulsive disorder. • An autoimmune hypothesis has been suggested for a subtype of Obsessive- Compulsive Disorder (OCD) with childhood onset. • For a proportion of OCD patients, autoimmune reactions towards neuronal structures are present.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 182
  182. 182. Cyrex™ Labs Array 5 - Neuroautoimmunity Panel Coming Soon www.CyrexLabs.comCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 183
  183. 183. Putting It All TogetherCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 184
  184. 184. What State is the Neuron In?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 185
  185. 185. What State is the Microglia In?Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 186
  186. 186. Earliest Signs of an Aging Brain • Fatigue promoted by brain activity – driving, reading, brain tasks • Depression – lack of healthy brain firing leads to depression • Poor Digestive Function – 90% of the brain’s output goes to the pontomedullary systemCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 187
  187. 187. Moderate Signs of an Aging Brain • Inability to focus or concentrate • Difficulty learning new tasks • Chronic constipation, opportunistic intestinal overgrowth, digestive enzyme insufficiency • Increased sympathetic tone leading to: – increased blood pressure – increased resting heart rate – stress susceptibility – poor blood flowCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 188
  188. 188. Significant Brain Aging • Inability to work professionally • Inability to appreciate life • Inability to perceive neurological loss • Early signs of neurological disease – tremors – inability to find directions – etc.Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 189
  189. 189. Severe Brain Aging • Neurodegenerative disease • Uncontrolled bladder tone • Bowel obstruction and inability to digest food • Inability to taste, smell, or develop social relationships • Dependency on family and medical staff for daily functionsCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 190
  190. 190. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 191
  191. 191. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 192
  192. 192. Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT For Nutritional Purposes Only 193
  193. 193. IMPORTANT & RELEVANT WEEKEND SEMINARS DEVELOPED BY DATIS KHARRAZIAN, DC, DHSc, MS, MNeuroSci, FACFN, FABVR, FAACP, DACNB, DABCN, DIBAK, CNSCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 194
  194. 194. FUNCTIONAL BLOOD CHEMISTRY CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS. THIS WEEKEND COURSE IS DESIGNED TO HELP YOU: • Understand the differences between functional and pathological ranges on Lab Reports. • Understand the key principles of laboratory biochemistry. • Understand how to differentially evaluate blood chemistry patterns for nutritional purposes. • Identify nutritional and herbal compounds that can be used to support nutritional imbalances through a review of medical literature. RECOMMENDED COURSES (NOT REQUIRED) & CDs TO PREPARE FOR THIS WEEKEND COURSE: • CARDIO GI & IMMUNE AXIS (2-HOUR SEMINAR CD ALSO AVAILABLE WITH NOTES).Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 195
  195. 195. MASTERING THE THYROID CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS. This course will redefine and create the new standard for natural medicine support of thyroid imbalances. Dr. Kharrazian has meticulously organized a comprehensive and detailed three-day course to help clinicians master the concepts of thyroid physiology, assessment, and clinical applications. The following tools and concepts will give you insight into this unique approach: • Thyroid-Immune-Nervous System-Endocrine crosstalk and its clinical implications • The impact of thyroid hormones on every major physiological process • A step-by-step approach to conducting a thyroid physical examination • A complete review of the literature on natural supplements that supports or disrupts thyroid function • Identify 24 common and newly highlighted patterns that lead to thyroid imbalances on lab tests RECOMMENDED COURSES (NOT REQUIRED) & CDs TO PREPARE FOR THIS WEEKEND COURSE: • THYROID-BRAIN-IMMUNE PHYSIOLOGICAL CROSSTALK • AUTOIMMUNE THYROID RESEARCH AND PRACTICE UPDATES (2-HOUR SEMINAR OR CD ALSO AVAILABLE WITH NOTES) • THYROID PRINCIPLES AND CASE STUDIES (2-HOUR SEMINAR OR CD ALSO AVAILABLE WITH NOTES)Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 196
  196. 196. NEUROTRANSMITTERS & BRAIN CEUs AVAILABLE. PLEASE INQUIRE FOR DETAILS. Dr. Kharrazian reviews physiological interactions among neurotransmitters, hormones, and the immune system. Clinical applications regarding questionnaire forms, laboratory tests, and nutritional supplements will be emphasized in the course. A complete review of the literature that pertains to natural supplements that support neurotransmitters, hormones, and the immune system will be provided in the course book. Numerous clinical pearls and case studies will be presented to provide information that can be used effectively by the practicing clinician. TAKE YOUR PRACTICE AND CLIENTS’ HEALTH TO THE NEXT LEVEL WITH THIS COURSE! RECOMMENDED COURSES (NOT REQUIRED) & CDs TO PREPARE FOR THIS WEEKEND COURSE: • INTRODUCTION TO NEUROCHEMISTRY (2-HOUR SEMINAR) • FUNCTIONAL BLOOD CHEMISTRY & FUNCTIONAL ENDOCRINOLOGY (CEU-APPROVED WEEKEND COURSES)Copyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 197
  197. 197. For dates and additional information: PLEASE LOOK FOR OUR WEEKEND & 2-HOUR COURSE SCHEDULE! www.apexseminars.comCopyright © 2011 Datis Kharrazian. All Rights Reserved.SMRAB09(06092011)BROCK.PPT 198

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