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Respiratory Telemetry in Large Species
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Respiratory Telemetry in Large Species

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  • 1. Respiratory Telemetry inLarge SpeciesRecording Respiratory Data, BP and ECG Rat Dual Pressure Telemetry 1
  • 2. CorDynamics introduces telemetry that records respiratoryparameters along with blood pressure and ECG in large animals Multiple options 1) blood pressure, ECG, and respiratory parameters - simultaneous and continuous recording - combines two ICH S7 assessments in one study 2) can be used in multiple species - rabbit, dog, pig, NHP Pharmacological validation - bethanechol (cholinergic agonist)
  • 3. Effects of bethanechol on heart rate Effect of Bethanechol (subcutaneous) on Heart Rate in the Conscious, Telemetrized Rabbit 350 300 250 200 HR (bpm) 150 100 Vehicle (n=4) 50 10 mg/kg (n=4) 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  • 4. Effects of bethanechol on tidal volume Effect of Bethanechol (subcutaneous) on Tidal Volume in the Conscious, Telemetrized Rabbit 30 25 20 TV (ml) 15 10 5 Vehicle (n=4) 10 mg/kg (n=4) 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  • 5. Effects of bethanechol on minute volume Effect of Bethanechol (subcutaneous) on Minute Volume in the Conscious, Telemetrized Rabbit 3500 Vehicle (n=4) 3000 10 mg/kg (n=4) 2500 MV (ml) 2000 1500 1000 500 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  • 6. Effects of bethanechol on respiratory rate Effect of Bethanechol (subcutaneous) on Respiratory Rate in the Conscious, Telemetrized Rabbit 300 Vehicle (n=4) 250 10 mg/kg (n=4) 200 Rf (breaths/min) 150 100 50 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)