Dual Pressure Telemetry

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Using dual pressure telemetry, systemic blood pressure AND either pulmonary artery pressure or left ventricular pressure can be measured in small species—simultaneously. Dual pressure telemetry also generates ECGs.

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Dual Pressure Telemetry

  1. 1. Rat Dual Pressure TelemetryDouble the Data 1
  2. 2. CorDynamics introduces telemetry that records two pressurechannels along with ECG in the rat – simultaneously! Many options 1) systemic blood pressure and pulmonary artery pressure - for differential effects on both arterial beds - to study PAH (pulmonary arterial hypertension) 2) systemic blood pressure and left ventricular pressure - test article effects on cardiac function and systemic BP Pharmacological validation - isoproterenol (β-adrenergic agonist) - hydralazine (direct vasodilator)
  3. 3. Effects of hydralazine or isoproterenol on heart rate Effect of Isoproterenol (SQ) or Hydralazine (IV) on Heart Rate in the Conscious, Telemetrized Male Rat 600 500 400 HR (bpm) 300 200 VEHICLE (n=4) 100 ISOPROTERENOL 25 mg/kg (n=4) HYDRALAZINE 1 mg/kg (n=4) 0 -70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130 Time (minutes)
  4. 4. Effects of hydralazine or isoproterenol on blood pressure Effect of Isoproterenol (SQ) or Hydralazine (IV) on Mean Arterial Pressure in the Conscious, Telemetrized Male Rat 140 120 100 MAP (mm Hg) 80 60 40 VEHICLE (n=4) ISOPROTERENOL 25 mg/kg (n=4) 20 HYDRALAZINE 1 mg/kg (n=4) 0 -70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130 Time (minutes)
  5. 5. Effectsof hydralazine or isoproterenol on LV contractility Effect of Isoproterenol (SQ) or Hydralazine (IV) on Maximum Left Ventricular dP/dt in the Conscious, Telemetrized Male Rat 18000 16000 14000 dP/dt (mm Hg/sec) 12000 10000 8000 6000 VEHICLE (n=4) 4000 ISOPROTERENOL 25 mg/kg (n=4) 2000 HYDRALAZINE 1 mg/kg (n=4) 0 -70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130 Time (minutes)

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