CorDynamics adds a powerful capability to its leading suite ofpulmonary arterial hypertension models – the ability to reco...
Telemetry pressure catheter was placed into pulmonary artery viaright ventricle- animals were allowed to recover, administ...
Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat                     Pulmonary Arterial Hypertensio...
Upcoming SlideShare
Loading in …5
×

Monitoring Pulmonary Arterial Hypertension with Telemetry

700 views
578 views

Published on

CorDynamics adds a powerful capability to its leading suite of pulmonary arterial hypertension models – the ability to record pulmonary artery pressures in the rat.

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
700
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
6
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Monitoring Pulmonary Arterial Hypertension with Telemetry

  1. 1. CorDynamics adds a powerful capability to its leading suite ofpulmonary arterial hypertension models – the ability to recordpulmonary artery pressures in the rat Multiple options 1) single pressure OR dual pressure - for differential effects on both arterial beds 2) increased frequency of pulmonary artery pressure readings - characterize development of PAH - critical to test efficacy in prevention AND reversal mode - design studies with more efficiency
  2. 2. Telemetry pressure catheter was placed into pulmonary artery viaright ventricle- animals were allowed to recover, administered SU5416, then placed in low oxygen environment- low technical failure rateClinical observations consistent with development of strongpulmonary hypertension- At Day 42, 438% increase in pulmonary artery pressure vs. baseline- at Day 42, animals euthanized and robust RV hypertrophy confirmed - mean RV/LV+S ratio was .624 ± .079; normal = ~ .300
  3. 3. Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat Pulmonary Arterial Hypertension Model Induced with Semaxanib (Day 1) and a Low Oxygen Environment - Systolic Pulmonary Artery Pressure 180 160 140 120(mm Hg) 100 80 60 40 Vehicle 20 0 -5 0 5 10 15 20 25 30 35 40 45 Days of Hypoxia

×